JP7022069B2 - ラパドシン（Ｒａｐａｄｏｃｉｎｓ）、受動拡散型ヌクレオシド輸送体１阻害剤及びその使用 - Google Patents

ラパドシン（Ｒａｐａｄｏｃｉｎｓ）、受動拡散型ヌクレオシド輸送体１阻害剤及びその使用 Download PDF

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JP7022069B2
JP7022069B2 JP2018540114A JP2018540114A JP7022069B2 JP 7022069 B2 JP7022069 B2 JP 7022069B2 JP 2018540114 A JP2018540114 A JP 2018540114A JP 2018540114 A JP2018540114 A JP 2018540114A JP 7022069 B2 JP7022069 B2 JP 7022069B2
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improvement
improved
nucleoside
compound
disease
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JP2019508397A5 (https=
JP2019508397A (ja
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リュー ジュン
ワン ジンシン
サン チャオリ
ホン サム
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Johns Hopkins University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • A61K38/07—Tetrapeptides
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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JP2018540114A 2016-02-04 2017-02-03 ラパドシン（Ｒａｐａｄｏｃｉｎｓ）、受動拡散型ヌクレオシド輸送体１阻害剤及びその使用 Active JP7022069B2 (ja)

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US201662291428P 2016-02-04 2016-02-04
US62/291,428 2016-02-04
PCT/US2017/016494 WO2017136717A1 (en) 2016-02-04 2017-02-03 Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

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JP2019508397A JP2019508397A (ja) 2019-03-28
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US (2) US10774110B2 (https=)
EP (2) EP3411032B1 (https=)
JP (1) JP7022069B2 (https=)
CN (2) CN113999281A (https=)
AU (1) AU2017214557B2 (https=)
CA (1) CA3013650A1 (https=)
ES (1) ES2837484T3 (https=)
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