JP7017565B2 - 制御試料蒸発による無損失クライオ・グリッド調製 - Google Patents

制御試料蒸発による無損失クライオ・グリッド調製 Download PDF

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JP7017565B2
JP7017565B2 JP2019520381A JP2019520381A JP7017565B2 JP 7017565 B2 JP7017565 B2 JP 7017565B2 JP 2019520381 A JP2019520381 A JP 2019520381A JP 2019520381 A JP2019520381 A JP 2019520381A JP 7017565 B2 JP7017565 B2 JP 7017565B2
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JP2019537709A (ja
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ブラウン、トマス
アーノルト、シュテファン
シュタールベルク、ヘニンク
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ウニヴェアズィテート バーゼル
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Length Measuring Devices By Optical Means (AREA)
JP2019520381A 2016-10-17 2017-10-17 制御試料蒸発による無損失クライオ・グリッド調製 Active JP7017565B2 (ja)

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EP16194230.5 2016-10-17
EP16194230 2016-10-17
PCT/EP2017/076467 WO2018073242A1 (en) 2016-10-17 2017-10-17 Lossless cryo-grid preparation by controlled sample evaporation

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JP2019537709A JP2019537709A (ja) 2019-12-26
JP2019537709A5 JP2019537709A5 (https=) 2020-11-26
JP7017565B2 true JP7017565B2 (ja) 2022-02-08

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US (1) US11860071B2 (https=)
EP (1) EP3526579A1 (https=)
JP (1) JP7017565B2 (https=)
CN (1) CN110062880B (https=)
WO (1) WO2018073242A1 (https=)

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US20160015025A1 (en) 2013-03-15 2016-01-21 Regents Of The University Of Minnesota Cryopreservative compostions and methods
US11122796B1 (en) 2016-02-19 2021-09-21 Regents Of The University Of Minnesota Cryoprotection compositions and methods
US11311008B2 (en) 2016-04-19 2022-04-26 Regents Of The University Of Minnesota. Cryopreservation compositions and methods involving nanowarming
US20210293674A1 (en) * 2018-07-23 2021-09-23 Regents Of The University Of Minnesota Systems and methods for cryopreservation of biomaterials
US11035766B2 (en) 2019-02-14 2021-06-15 Nanosoft, Llc. Cryogenic transmission electron microscopy sample preparation
US11703429B2 (en) 2019-02-14 2023-07-18 Nanosoft, LLC Cryogenic transmission electron microscopy sample preparation
WO2020176498A1 (en) 2019-02-28 2020-09-03 Regents Of The University Of Minnesota High throughput system for production and vitrification of biomaterials in cryoprotectant droplets
CN109972207B (zh) * 2019-05-16 2024-03-08 沈阳工程学院 一种磁场可控式液桥生成器
US11101104B2 (en) * 2019-08-30 2021-08-24 Fei Company Multi modal cryo compatible GUID grid
CN110823931B (zh) * 2019-10-16 2020-10-27 中国科学院生物物理研究所 一种冷冻电镜样品制备方法
US12467740B2 (en) 2020-02-13 2025-11-11 Hamamatsu Photonics K.K. Imaging unit and measurement device
EP3869182A1 (en) * 2020-02-19 2021-08-25 FEI Company Device and method for determining a property of a sample that is to be used in a charged particle microscope
CN111929248A (zh) * 2020-08-26 2020-11-13 重庆渝微电子技术研究院有限公司 半导体冷热台
WO2022155306A1 (en) * 2021-01-13 2022-07-21 Wisconsin Alumni Research Foundation Freezing and jacketing gas-phase biomolecules with amorphous ice for electron microscopy
CN113101990B (zh) * 2021-04-13 2022-06-21 广西大学 一种用于微流体集成芯片中流体试剂储存和自触发并延时释放的方法
WO2024061904A1 (en) * 2022-09-20 2024-03-28 Cryowrite Ag Gripper unit and transfer system
WO2025029985A1 (en) * 2023-08-01 2025-02-06 Wisconsin Alumni Research Foundation Compositions and methods for preparation of a cryogenic electron microscopy sample
WO2025036907A1 (en) 2023-08-15 2025-02-20 Cryowrite Ag Method for cooling a sample solution in a pipette, a pipette holding and cooling unit and a cooling plate
WO2025157760A1 (en) * 2024-01-25 2025-07-31 Roche Diagnostics International Ag Methods and systems for preparing a sample on a substrate

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EP3018467A1 (en) 2014-11-07 2016-05-11 Linkam Scienctific Instruments Ltd. Microscopic sample preparation

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JP3221797B2 (ja) * 1994-06-14 2001-10-22 株式会社日立製作所 試料作成方法及びその装置
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EP3018467A1 (en) 2014-11-07 2016-05-11 Linkam Scienctific Instruments Ltd. Microscopic sample preparation

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JP2019537709A (ja) 2019-12-26
EP3526579A1 (en) 2019-08-21
WO2018073242A1 (en) 2018-04-26
CN110062880A (zh) 2019-07-26
US11860071B2 (en) 2024-01-02
US20190250078A1 (en) 2019-08-15
CN110062880B (zh) 2022-09-20

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