JP7013369B2 - Ｅｚｈ２阻害剤により卵巣の悪性ラブドイド腫瘍（ｍｒｔｏ）／高カルシウム血症型の卵巣の小細胞癌（ｓｃｃｏｈｔ）を処置するための方法 - Google Patents

Ｅｚｈ２阻害剤により卵巣の悪性ラブドイド腫瘍（ｍｒｔｏ）／高カルシウム血症型の卵巣の小細胞癌（ｓｃｃｏｈｔ）を処置するための方法 Download PDF

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JP7013369B2
JP7013369B2 JP2018515673A JP2018515673A JP7013369B2 JP 7013369 B2 JP7013369 B2 JP 7013369B2 JP 2018515673 A JP2018515673 A JP 2018515673A JP 2018515673 A JP2018515673 A JP 2018515673A JP 7013369 B2 JP7013369 B2 JP 7013369B2
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smarca4
pharmaceutical composition
sccoht
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ezh2
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JP2018529698A (ja
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キールハック ハイク
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エピザイム，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2018515673A 2015-09-25 2016-09-26 Ｅｚｈ２阻害剤により卵巣の悪性ラブドイド腫瘍（ｍｒｔｏ）／高カルシウム血症型の卵巣の小細胞癌（ｓｃｃｏｈｔ）を処置するための方法 Expired - Fee Related JP7013369B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562233146P 2015-09-25 2015-09-25
US62/233,146 2015-09-25
US201562252188P 2015-11-06 2015-11-06
US62/252,188 2015-11-06
PCT/US2016/053673 WO2017053930A2 (en) 2015-09-25 2016-09-26 Method of treating malignant rhabdoid tumor of the ovary (mrto)/small cell cancer of the ovary of the hypercalcemic type (sccoht) with an ezh2 inhibitor

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JP2018529698A JP2018529698A (ja) 2018-10-11
JP2018529698A5 JP2018529698A5 (OSRAM) 2019-11-07
JP7013369B2 true JP7013369B2 (ja) 2022-02-15

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US (3) US20180296563A1 (OSRAM)
EP (1) EP3352761A4 (OSRAM)
JP (1) JP7013369B2 (OSRAM)
KR (1) KR20180054793A (OSRAM)
CN (2) CN114533880B (OSRAM)
AU (2) AU2016325643B2 (OSRAM)
CA (1) CA2999898A1 (OSRAM)
EA (1) EA201890801A1 (OSRAM)
IL (2) IL258302A (OSRAM)
MX (2) MX2018003663A (OSRAM)
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AU2016325643B2 (en) 2022-07-21
KR20180054793A (ko) 2018-05-24
US20200138825A1 (en) 2020-05-07
AU2022256115A1 (en) 2022-11-17
CN114533880A (zh) 2022-05-27
JP2018529698A (ja) 2018-10-11
CN114533880B (zh) 2023-08-22
WO2017053930A3 (en) 2018-04-12
AU2016325643A1 (en) 2018-04-12
IL280760A (en) 2021-04-29
EP3352761A4 (en) 2019-04-24
US20210121470A1 (en) 2021-04-29
CN108349958A (zh) 2018-07-31
MX2022013390A (es) 2023-01-04
WO2017053930A2 (en) 2017-03-30
EP3352761A2 (en) 2018-08-01
EA201890801A1 (ru) 2018-09-28
IL258302A (en) 2018-05-31
CA2999898A1 (en) 2017-03-30
US20180296563A1 (en) 2018-10-18
MX2018003663A (es) 2018-08-14
SG10201908323TA (en) 2019-10-30
CN108349958B (zh) 2022-02-15

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