JP7011389B2 - オリゴヌクレオチドの全身性イン-ビボ送達 - Google Patents

オリゴヌクレオチドの全身性イン-ビボ送達 Download PDF

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JP7011389B2
JP7011389B2 JP2016519662A JP2016519662A JP7011389B2 JP 7011389 B2 JP7011389 B2 JP 7011389B2 JP 2016519662 A JP2016519662 A JP 2016519662A JP 2016519662 A JP2016519662 A JP 2016519662A JP 7011389 B2 JP7011389 B2 JP 7011389B2
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oligonucleotide
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oligonucleotides
nucleic acid
rna
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JP2016521753A (ja
JP2016521753A5 (enExample
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パッカード ビバリー
コモリヤ アキラ
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オンコイミューニン,インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
JP2016519662A 2013-06-12 2014-06-12 オリゴヌクレオチドの全身性イン-ビボ送達 Active JP7011389B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361834383P 2013-06-12 2013-06-12
US61/834,383 2013-06-12
PCT/US2014/042202 WO2014201306A1 (en) 2013-06-12 2014-06-12 Systemic in vivo delivery of oligonucleotides

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JP2016521753A JP2016521753A (ja) 2016-07-25
JP2016521753A5 JP2016521753A5 (enExample) 2021-07-29
JP7011389B2 true JP7011389B2 (ja) 2022-01-26

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JP2019088413A Pending JP2019135259A (ja) 2013-06-12 2019-05-08 オリゴヌクレオチドの全身性イン−ビボ送達

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US (3) US20160367587A1 (enExample)
EP (1) EP3007705A4 (enExample)
JP (2) JP7011389B2 (enExample)
CA (1) CA2951816A1 (enExample)
WO (1) WO2014201306A1 (enExample)

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EP3929293A3 (en) 2015-04-03 2022-03-16 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
AU2016374497B2 (en) 2015-12-16 2022-03-10 The Walter And Eliza Hall Institute Of Medical Research Inhibition of cytokine-induced SH2 protein in NK cells
KR20250112919A (ko) 2015-12-21 2025-07-24 노파르티스 아게 타우 발현을 감소시키기 위한 조성물 및 방법
WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
WO2018237245A1 (en) 2017-06-23 2018-12-27 University Of Massachusetts TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS
EP3806850A2 (en) * 2018-06-15 2021-04-21 Ideaya Biosciences, Inc. Methods of inhibiting proliferative cells
BR112021002440A2 (pt) 2018-08-10 2021-05-04 University Of Massachusetts oligonucleotídeos modificados visando snps
WO2020041769A1 (en) 2018-08-23 2020-02-27 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
EP3946369A4 (en) * 2019-03-26 2023-10-18 University Of Massachusetts MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY
JP7725370B2 (ja) * 2019-04-03 2025-08-19 ブリストル-マイヤーズ スクイブ カンパニー Angptl2アンチセンスオリゴヌクレオチドおよびその使用
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
WO2021132648A1 (ja) * 2019-12-27 2021-07-01 ルクサナバイオテク株式会社 Recqlの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途
EP4087587A4 (en) * 2020-01-11 2024-08-07 Oncoimmunin, Inc. TARGETED AND LOCALIZED IN VIVO DELIVERY OF OLIGONUCLEOTIDES
JP2023526719A (ja) * 2020-03-10 2023-06-23 ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド がん及びウイルス感染症治療のための遺伝子発現調節剤の送達
AU2021244600A1 (en) 2020-03-26 2022-11-03 University Of Massachusetts Synthesis of modified oligonucleotides with increased stability
CA3174079A1 (en) 2020-05-26 2021-12-02 Anastasia Khvorova Synthetic oligonucleotides having regions of block and cluster modifications
US20230065782A1 (en) * 2021-07-14 2023-03-02 Oncoimmunin, Inc. Targeted and localized in vivo delivery of oligonucleotides
WO2025171411A1 (en) 2024-02-09 2025-08-14 Herophilus, Inc. Compositions and methods related to modulating macrophage migration inhibitory factor (mif)-cd74 signaling and related treatments for neuroinflammatory conditions
WO2025227100A2 (en) * 2024-04-26 2025-10-30 Purdue Research Foundation Targeted delivery of therapeutic agent to retinal pigment epithelium in treatment of ocular diseases

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Also Published As

Publication number Publication date
EP3007705A4 (en) 2017-02-15
JP2019135259A (ja) 2019-08-15
JP2016521753A (ja) 2016-07-25
CA2951816A1 (en) 2014-12-18
US20190183918A1 (en) 2019-06-20
US20160367587A1 (en) 2016-12-22
EP3007705A1 (en) 2016-04-20
WO2014201306A1 (en) 2014-12-18
US20220033815A1 (en) 2022-02-03

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