JP7005007B2 - 固体形態 - Google Patents

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JP7005007B2
JP7005007B2 JP2017557899A JP2017557899A JP7005007B2 JP 7005007 B2 JP7005007 B2 JP 7005007B2 JP 2017557899 A JP2017557899 A JP 2017557899A JP 2017557899 A JP2017557899 A JP 2017557899A JP 7005007 B2 JP7005007 B2 JP 7005007B2
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xrpd
diffraction pattern
compound
particular embodiment
formula
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JP2018516883A (ja
JP2018516883A5 (cg-RX-API-DMAC7.html
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ラルフ ディオドネ，
ウルス シュヴィッター，
レネ トルッサルディ，
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オリソン ヘノミクス エセ． アー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/78—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton from carbonyl compounds, e.g. from formaldehyde, and amines having amino groups bound to carbon atoms of six-membered aromatic rings, with formation of methylene-diarylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017557899A 2015-05-06 2016-05-02 固体形態 Active JP7005007B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021060013A JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166641.9 2015-05-06
EP15166641.9A EP3090998A1 (en) 2015-05-06 2015-05-06 Solid forms
PCT/EP2016/059726 WO2016177656A1 (en) 2015-05-06 2016-05-02 Solid forms

Related Child Applications (1)

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JP2021060013A Division JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Publications (3)

Publication Number Publication Date
JP2018516883A JP2018516883A (ja) 2018-06-28
JP2018516883A5 JP2018516883A5 (cg-RX-API-DMAC7.html) 2019-06-06
JP7005007B2 true JP7005007B2 (ja) 2022-02-04

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JP2021060013A Pending JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

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US (1) US10221125B2 (cg-RX-API-DMAC7.html)
EP (2) EP3090998A1 (cg-RX-API-DMAC7.html)
JP (2) JP7005007B2 (cg-RX-API-DMAC7.html)
KR (1) KR102666390B1 (cg-RX-API-DMAC7.html)
CN (1) CN107735394B (cg-RX-API-DMAC7.html)
AR (1) AR104505A1 (cg-RX-API-DMAC7.html)
AU (1) AU2016259054B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017023740B1 (cg-RX-API-DMAC7.html)
CA (1) CA2984203C (cg-RX-API-DMAC7.html)
ES (1) ES2969970T3 (cg-RX-API-DMAC7.html)
HU (1) HUE065558T2 (cg-RX-API-DMAC7.html)
IL (1) IL255194B (cg-RX-API-DMAC7.html)
MX (1) MX378732B (cg-RX-API-DMAC7.html)
PL (1) PL3292100T3 (cg-RX-API-DMAC7.html)
WO (1) WO2016177656A1 (cg-RX-API-DMAC7.html)

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EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
CA3253937A1 (en) 2016-03-15 2025-03-04 Oryzon Genomics, S.A. Combinations of Lysine-Specific Demethylase 1 Inhibitors for the Treatment of Hematological Maligna
CA3017411C (en) 2016-03-15 2024-06-25 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for use in the treatment of solid tumors
EP3430015B9 (en) 2016-03-16 2025-12-31 Oryzon Genomics, S.A. METHODS FOR DETERMINING THE ENGAGEMENT OF A KDM1A TARGET AND CORRESPONDING USEFUL CHEMOPROBE
ES2732669T3 (es) 2016-06-10 2019-11-25 Oryzon Genomics Sa Tratamiento de la esclerosis múltiple
AU2018309372B2 (en) 2017-08-03 2024-08-15 Oryzon Genomics, S.A. Methods of treating behavior alterations
CN112040934A (zh) * 2018-05-04 2020-12-04 奥莱松基因组股份有限公司 稳定的药物制剂
AU2020242302B2 (en) 2019-03-20 2025-10-30 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
CN113631164A (zh) 2019-03-20 2021-11-09 奥莱松基因组股份有限公司 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法
WO2020193631A1 (en) * 2019-03-25 2020-10-01 Oryzon Genomics, S.A. Combinations of iadademstat for cancer therapy
JP2022546908A (ja) 2019-07-05 2022-11-10 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
AU2022254484A1 (en) 2021-04-08 2023-11-09 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for treating myeloid cancers
WO2023217758A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
JP2025516648A (ja) 2022-05-09 2025-05-30 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法
KR20250109775A (ko) 2022-11-24 2025-07-17 오리존 지노믹스 에스.에이. 암 치료를 위한 lsd1 억제제 및 메닌 억제제의 조합

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Ｍｉｎｏ Ｒ．Ｃａｉｒａ，Ｃｒｙｓｔａｌｌｉｎｅ Ｐｏｌｙｍｏｒｐｈｉｓｍ ｏｆ Ｏｒｇａｎｉｃ Ｃｏｍｐｏｕｎｄｓ，Ｔｏｐｉｃｓ ｉｎ Ｃｕｒｒｅｎｔ Ｃｈｅｍｉｓｔｒｙ，ドイツ，Ｓｐｒｉｎｇｅｒ，１９９８年，Ｖｏｌ．１９８，ｐｐ．１６３－２０８，ＵＲＬ，ｈｔｔｐｓ：／／ｌｉｎｋ．ｓｐｒｉｎｇｅｒ．ｃｏｍ／ｃｈａｐｔｅｒ／１０．１００７／３－５４０－６９１７８－２＿５

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ES2969970T3 (es) 2024-05-23
CA2984203C (en) 2024-07-02
MX378732B (es) 2025-03-11
CN107735394B (zh) 2021-11-02
HK1252089A1 (en) 2019-05-17
EP3090998A1 (en) 2016-11-09
HUE065558T2 (hu) 2024-06-28
IL255194B (en) 2021-03-25
KR102666390B1 (ko) 2024-05-21
PL3292100T3 (pl) 2024-04-22
EP3292100C0 (en) 2023-11-15
MX2017014035A (es) 2018-03-01
HK1245235A1 (zh) 2018-08-24
AR104505A1 (es) 2017-07-26
AU2016259054B2 (en) 2020-08-13
CN107735394A (zh) 2018-02-23
JP2018516883A (ja) 2018-06-28
BR112017023740A2 (pt) 2018-07-17
AU2016259054A1 (en) 2017-11-16
BR112017023740B1 (pt) 2023-11-07
JP2021119136A (ja) 2021-08-12
IL255194A0 (en) 2017-12-31
WO2016177656A1 (en) 2016-11-10
CA2984203A1 (en) 2016-11-10
KR20180022660A (ko) 2018-03-06
US20180086692A1 (en) 2018-03-29
EP3292100A1 (en) 2018-03-14
EP3292100B1 (en) 2023-11-15
US10221125B2 (en) 2019-03-05

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