JP7000315B2 - 高結合活性ｈｐｖ ｔ細胞受容体 - Google Patents

高結合活性ｈｐｖ ｔ細胞受容体 Download PDF

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JP7000315B2
JP7000315B2 JP2018519710A JP2018519710A JP7000315B2 JP 7000315 B2 JP7000315 B2 JP 7000315B2 JP 2018519710 A JP2018519710 A JP 2018519710A JP 2018519710 A JP2018519710 A JP 2018519710A JP 7000315 B2 JP7000315 B2 JP 7000315B2
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ブランケンシュタイン，トーマス
ウィリンズキー，ゲラルド
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マックス－デルブリュック－ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ－ゲマインシャフト
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/565—Complementarity determining region [CDR]
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018519710A 2015-10-16 2016-10-13 高結合活性ｈｐｖ ｔ細胞受容体 Expired - Fee Related JP7000315B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15190230.1 2015-10-16
EP15190230.1A EP3156067A1 (en) 2015-10-16 2015-10-16 High avidity hpv t-cell receptors
PCT/EP2016/074612 WO2017064198A1 (en) 2015-10-16 2016-10-13 High avidity hpv t-cell receptors

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JP2018535668A JP2018535668A (ja) 2018-12-06
JP2018535668A5 JP2018535668A5 (OSRAM) 2019-11-21
JP7000315B2 true JP7000315B2 (ja) 2022-02-04

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JP2018519710A Expired - Fee Related JP7000315B2 (ja) 2015-10-16 2016-10-13 高結合活性ｈｐｖ ｔ細胞受容体

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US (1) US11401316B2 (OSRAM)
EP (2) EP3156067A1 (OSRAM)
JP (1) JP7000315B2 (OSRAM)
CN (1) CN108135998B (OSRAM)
AU (1) AU2016336817C1 (OSRAM)
CA (1) CA3001395A1 (OSRAM)
WO (1) WO2017064198A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
DE102017114737A1 (de) 2017-06-30 2019-01-03 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
EP3692063A1 (en) * 2017-10-03 2020-08-12 Juno Therapeutics, Inc. Hpv-specific binding molecules
CN109053879B (zh) * 2018-08-22 2020-12-25 深圳市宝安区中心医院 一种治疗宫颈癌的scFv抗体及其应用
US12404331B2 (en) 2019-04-19 2025-09-02 Tcrcure Biopharma Corp. Anti-PD-1 antibodies and uses thereof
CN113072635B (zh) * 2020-01-06 2023-08-25 香雪生命科学技术（广东）有限公司 一种识别hpv抗原的t细胞受体及其编码序列
WO2021155518A1 (en) * 2020-02-05 2021-08-12 Tcrcure Biopharma Corp Anti-hpv t cell receptors and engineered cells
CN113321726B (zh) * 2020-02-28 2024-05-28 香雪生命科学技术（广东）有限公司 一种识别hpv的t细胞受体
EP4125949A4 (en) * 2020-03-23 2024-05-22 The Council of the Queensland Institute of Medical Research COMPOSITIONS AND METHODS FOR TARGETING HPV-INFECTED CELLS
CN116096740A (zh) * 2020-06-09 2023-05-09 得克萨斯州大学系统董事会 经改造t细胞受体和使用方法
CN113801217B (zh) * 2020-06-17 2025-12-23 香雪生命科学技术（广东）有限公司 一种识别hpv抗原的高亲和力t细胞受体
WO2022060904A1 (en) 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells
CN114539385A (zh) * 2020-11-26 2022-05-27 香雪生命科学技术（广东）有限公司 一种识别hpv抗原的tcr
CN114853878A (zh) * 2021-02-03 2022-08-05 香雪生命科学技术（广东）有限公司 一种针对hpv的高亲和力tcr
WO2022187406A1 (en) 2021-03-03 2022-09-09 Juno Therapeutics, Inc. Combination of a t cell therapy and a dgk inhibitor
WO2023014337A1 (en) * 2021-08-04 2023-02-09 GUERRERO PRESTON Rafael Viral and host biomarkers for early detection, therapeutic effectiveness, and relapse monitoring of cancer linked to severe acute respiratory syndrome coronavirus 2 and human papilloma virus
CN116262779A (zh) * 2021-12-14 2023-06-16 深圳先进技术研究院 一种单细胞筛选鉴定人乳头瘤病毒特异性tcr的方法
CN115286690B (zh) * 2022-05-10 2023-06-20 广州医科大学 抗原短肽用于筛选治疗与hpv相关的疾病的药物中的用途及其筛选的tcr
CN115286698B (zh) * 2022-05-10 2023-09-01 广州医科大学 抗原短肽用于筛选治疗与hpv相关的疾病的药物中的用途及其筛选的tcr
WO2024054944A1 (en) 2022-09-08 2024-03-14 Juno Therapeutics, Inc. Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing
GB202311170D0 (en) * 2023-07-20 2023-09-06 Univ Oxford Innovation Ltd Antigen binding polypeptides
WO2026025092A1 (en) 2024-07-26 2026-01-29 Juno Therapeutics, Inc. Synthetic promoters for t cell expression

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070218080A1 (en) 2006-03-14 2007-09-20 Mackay Memorial Hospital Peptide antigen of human papillomavirus type 16 and application thereof
US20120121628A1 (en) 2010-11-15 2012-05-17 National Health Research Institutes Lipidated polyepitope vaccines
JP2015504895A (ja) 2012-01-13 2015-02-16 エーピーオー‐ティー ビー．ヴイ． 毒性部分を備える異常細胞拘束性免疫グロブリン
US20150175683A1 (en) 2012-06-26 2015-06-25 Apo-T B.V. Binding molecules targeting pathogens

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
EP1257289A1 (en) 2000-02-08 2002-11-20 The Penn State Research Foundation Immunotherapy using interleukin 13 receptor subunit alpha 2
US20100297093A1 (en) * 2007-09-25 2010-11-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Modified t cell receptors and related materials and methods
AU2011304728A1 (en) * 2010-09-20 2013-03-14 Biontech Ag Antigen-specific T cell receptors and T cell epitopes
CN110511960B (zh) 2013-07-15 2023-05-23 美国卫生和人力服务部 抗人乳头瘤病毒16 e6 t细胞受体
GB201322430D0 (en) * 2013-12-18 2014-02-05 Immunocore Ltd T cell receptors
US10202640B2 (en) * 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070218080A1 (en) 2006-03-14 2007-09-20 Mackay Memorial Hospital Peptide antigen of human papillomavirus type 16 and application thereof
US20120121628A1 (en) 2010-11-15 2012-05-17 National Health Research Institutes Lipidated polyepitope vaccines
JP2015504895A (ja) 2012-01-13 2015-02-16 エーピーオー‐ティー ビー．ヴイ． 毒性部分を備える異常細胞拘束性免疫グロブリン
US20150175683A1 (en) 2012-06-26 2015-06-25 Apo-T B.V. Binding molecules targeting pathogens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Genome Medicine，2013年，Vol.5:98，pp.1-13

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CA3001395A1 (en) 2017-04-20
AU2016336817B2 (en) 2021-02-04
CN108135998A (zh) 2018-06-08
US11401316B2 (en) 2022-08-02
AU2016336817B9 (en) 2021-02-11
AU2016336817A1 (en) 2018-05-31
AU2016336817C1 (en) 2021-05-13
US20190062398A1 (en) 2019-02-28
JP2018535668A (ja) 2018-12-06
EP3362090A1 (en) 2018-08-22
CN108135998B (zh) 2023-05-09
EP3156067A1 (en) 2017-04-19
WO2017064198A1 (en) 2017-04-20

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