JP6998938B2 - 再発性および／または難治性の固形腫瘍および非ホジキンリンパ腫の処置 - Google Patents

再発性および／または難治性の固形腫瘍および非ホジキンリンパ腫の処置 Download PDF

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JP6998938B2
JP6998938B2 JP2019506649A JP2019506649A JP6998938B2 JP 6998938 B2 JP6998938 B2 JP 6998938B2 JP 2019506649 A JP2019506649 A JP 2019506649A JP 2019506649 A JP2019506649 A JP 2019506649A JP 6998938 B2 JP6998938 B2 JP 6998938B2
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JP2019526546A (ja
JP2019526546A5 (OSRAM
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シュウ，ジャンチュン
チョウ，ロバート
グエン，アーロン
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セルジーン クオンティセル リサーチ，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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JP2019506649A 2016-08-10 2017-08-09 再発性および／または難治性の固形腫瘍および非ホジキンリンパ腫の処置 Active JP6998938B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662373263P 2016-08-10 2016-08-10
US62/373,263 2016-08-10
US201762468424P 2017-03-08 2017-03-08
US62/468,424 2017-03-08
PCT/US2017/046098 WO2018031658A1 (en) 2016-08-10 2017-08-09 Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas

Publications (3)

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JP2019526546A JP2019526546A (ja) 2019-09-19
JP2019526546A5 JP2019526546A5 (OSRAM) 2020-09-17
JP6998938B2 true JP6998938B2 (ja) 2022-02-04

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US (5) US10328077B2 (OSRAM)
EP (2) EP3496721B1 (OSRAM)
JP (1) JP6998938B2 (OSRAM)
KR (1) KR102469406B1 (OSRAM)
CN (1) CN109803660A (OSRAM)
AU (2) AU2017310423B2 (OSRAM)
CA (1) CA3033634A1 (OSRAM)
ES (1) ES2972741T3 (OSRAM)
IL (2) IL303436A (OSRAM)
MX (1) MX381059B (OSRAM)
TW (1) TWI767928B (OSRAM)
WO (1) WO2018031658A1 (OSRAM)
ZA (1) ZA201901322B (OSRAM)

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KR102724968B1 (ko) * 2018-03-21 2024-10-31 수조우 푸허 바이오파마 컴퍼니 리미티드 Shp2 억제제 및 이의 용도
EP3983016A4 (en) * 2019-06-13 2023-06-07 Celgene Corporation METHODS OF TREATMENT OF CANCER BY TARGETING COLD TUMORS
KR20230035569A (ko) * 2020-06-05 2023-03-14 셀젠 콴티셀 리서치, 인크. 전립선암의 치료 방법
ES2919083R1 (es) * 2020-06-29 2022-07-26 Celgene Quanticel Res Inc Métodos de tratamiento de cáncer de próstata
WO2024119067A1 (en) 2022-12-02 2024-06-06 Neumora Therapeutics, Inc. Methods of treating neurological disorders
KR102670571B1 (ko) 2023-09-25 2024-05-31 주식회사 디에스더블유 의류 건조기용 공기 가열장치
CN119132626B (zh) * 2024-05-29 2025-10-28 中山大学孙逸仙纪念医院 一种基于三级淋巴结构的新辅后三阴性乳腺癌预后预测方法及系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508400A (ja) 2009-10-21 2013-03-07 イミュノジェン・インコーポレーテッド 新規な投与レジメンおよび治療法
US20140155339A1 (en) 2012-11-30 2014-06-05 Darlene E. McCord Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition
WO2015168466A1 (en) 2014-05-01 2015-11-05 Quanticel Pharmaceuticals, Inc. Inhibitors of lysine specific demethylase-1

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Publication number Priority date Publication date Assignee Title
US20090181997A1 (en) * 2007-12-27 2009-07-16 Grayzel David Therapeutic cancer treatments
WO2012009475A1 (en) * 2010-07-14 2012-01-19 Oregon Health & Science University Methods of treating cancer with inhibition of lysine-specific demethylase 1
US9527835B2 (en) * 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508400A (ja) 2009-10-21 2013-03-07 イミュノジェン・インコーポレーテッド 新規な投与レジメンおよび治療法
US20140155339A1 (en) 2012-11-30 2014-06-05 Darlene E. McCord Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition
WO2015168466A1 (en) 2014-05-01 2015-11-05 Quanticel Pharmaceuticals, Inc. Inhibitors of lysine specific demethylase-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Methods Enzymol.，2016年，Vol.573，p.261-278

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TW201804999A (zh) 2018-02-16
JP2019526546A (ja) 2019-09-19
IL264718A (OSRAM) 2019-03-31
US20180125844A1 (en) 2018-05-10
US20200113905A1 (en) 2020-04-16
CN109803660A (zh) 2019-05-24
US20190240223A1 (en) 2019-08-08
AU2022202495A1 (en) 2022-05-12
AU2017310423A8 (en) 2019-03-14
US20190240222A1 (en) 2019-08-08
IL303436A (en) 2023-08-01
MX2019001608A (es) 2019-08-29
EP4286381A2 (en) 2023-12-06
EP3496721A4 (en) 2020-04-15
US10849898B2 (en) 2020-12-01
IL264718B2 (en) 2023-11-01
MX381059B (es) 2025-04-01
KR20190038622A (ko) 2019-04-08
EP3496721A1 (en) 2019-06-19
IL264718B1 (en) 2023-07-01
EP4286381A3 (en) 2024-02-28
US10328077B2 (en) 2019-06-25
US10548896B2 (en) 2020-02-04
US10543213B2 (en) 2020-01-28
ZA201901322B (en) 2022-09-28
ES2972741T3 (es) 2024-06-14
TWI767928B (zh) 2022-06-21
CA3033634A1 (en) 2018-02-15
AU2017310423A1 (en) 2019-02-28
EP3496721B1 (en) 2023-12-06
WO2018031658A1 (en) 2018-02-15
US10960005B2 (en) 2021-03-30
US20200297727A1 (en) 2020-09-24
AU2017310423B2 (en) 2022-02-03
KR102469406B1 (ko) 2022-11-21

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