JP6976859B2 - ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 - Google Patents

ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 Download PDF

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JP6976859B2
JP6976859B2 JP2017559025A JP2017559025A JP6976859B2 JP 6976859 B2 JP6976859 B2 JP 6976859B2 JP 2017559025 A JP2017559025 A JP 2017559025A JP 2017559025 A JP2017559025 A JP 2017559025A JP 6976859 B2 JP6976859 B2 JP 6976859B2
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certain embodiments
actriib
seq
polypeptide
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JP2018520094A5 (OSRAM
JP2018520094A (ja
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エム．アティエ ケネス
ラアデム アブデラーマン
チョプラ ラジェシュ
バックストロム ジェイ
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Celgene Corp
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017559025A 2015-05-13 2016-05-12 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療 Expired - Fee Related JP6976859B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021131870A JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19
PCT/US2016/031999 WO2016183280A1 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using actrii ligand traps

Related Child Applications (1)

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JP2021131870A Division JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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JP2018520094A JP2018520094A (ja) 2018-07-26
JP2018520094A5 JP2018520094A5 (OSRAM) 2019-06-20
JP6976859B2 true JP6976859B2 (ja) 2021-12-08

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JP2017559025A Expired - Fee Related JP6976859B2 (ja) 2015-05-13 2016-05-12 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療
JP2021131870A Pending JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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JP2021131870A Pending JP2021191755A (ja) 2015-05-13 2021-08-13 ＡｃｔＲＩＩリガンドトラップを用いたβ−サラセミアの治療

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US (1) US20180125928A1 (OSRAM)
EP (1) EP3294320A4 (OSRAM)
JP (2) JP6976859B2 (OSRAM)
KR (1) KR102640198B1 (OSRAM)
CN (1) CN107847562A (OSRAM)
AU (2) AU2016261913B2 (OSRAM)
CA (1) CA2985777A1 (OSRAM)
HK (1) HK1251157A1 (OSRAM)
IL (2) IL284686B2 (OSRAM)
JO (1) JOP20160092B1 (OSRAM)
MY (1) MY189601A (OSRAM)
PH (1) PH12017502079A1 (OSRAM)
TN (1) TN2017000468A1 (OSRAM)
TW (2) TWI814187B (OSRAM)
WO (1) WO2016183280A1 (OSRAM)

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WO2011063018A1 (en) 2009-11-17 2011-05-26 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
MX366336B (es) 2012-11-02 2019-07-05 Celgene Corp Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros.
BR112016029226A2 (pt) 2014-06-13 2017-10-17 Acceleron Pharma Inc métodos e composições para o tratamento de úlceras
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
FI3227675T3 (fi) 2014-12-03 2023-05-25 Celgene Corp Aktiviini-actrii-antagonisteja ja niiden käyttöjä myelodysplastisen oireyhtymän hoitamiseksi
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
EP4190805A3 (en) 2015-05-20 2023-08-16 Celgene Corporation In vitro cell culture methods for beta-thalassemia using activin type ii receptor ligand traps
EP3370754A4 (en) 2015-11-04 2019-10-23 Acceleron Pharma Inc. METHOD FOR INCREASING ERYTHROCYTE CONCENTRATION AND TREATMENT OF INEFFICIENT ERYTHROPOIESE
JP7072507B2 (ja) 2015-11-23 2022-05-20 アクセルロン ファーマ インコーポレイテッド 眼の障害を処置するための方法
RU2748278C2 (ru) 2016-07-15 2021-05-21 Акселерон Фарма Инк. Композиции и способы лечения легочной гипертензии
MX2019001043A (es) 2016-07-27 2019-09-26 Acceleron Pharma Inc Metodos y composiciones para el tratamiento de la mielofibrosis.
JP7051846B2 (ja) 2016-11-10 2022-04-11 ケロス セラピューティクス インコーポレイテッド アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物
HUE068733T2 (hu) * 2017-06-14 2025-01-28 Celgene Corp Eljárások mieloproliferatív neoplazma-asszociált mielofibrózis anémia kezelésére
JP7258021B2 (ja) 2017-11-09 2023-04-14 ケロス セラピューティクス インコーポレイテッド アクチビンＩＩａ型受容体変異体を含む医薬組成物
KR20200109330A (ko) 2018-01-12 2020-09-22 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법
EP3788065B1 (en) 2018-04-30 2025-08-27 The Children's Hospital Of Philadelphia Improving anemias by combining agents
CA3098679A1 (en) 2018-05-09 2019-11-14 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
CN112969471A (zh) * 2018-10-31 2021-06-15 细胞基因公司 使用激活素-actrii配体陷阱治疗具有环状铁粒幼细胞的受试者中由极低、低或中等风险的骨髓增生异常综合征引起的贫血
CN114302882A (zh) 2019-07-19 2022-04-08 威佛（国际）股份公司 用于治疗输血依赖型β-地中海贫血（tdt）的膜铁转运蛋白抑制剂
CN112924684B (zh) * 2019-12-05 2022-07-29 中国科学院大连化学物理研究所 用于区分抑郁症和非抑郁症的生物标志物和包括其的诊断试剂盒
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Also Published As

Publication number Publication date
NZ737043A (en) 2025-02-28
TW201709927A (zh) 2017-03-16
AU2016261913A1 (en) 2017-11-30
PH12017502079A1 (en) 2018-06-11
AU2021258087A1 (en) 2021-11-25
TN2017000468A1 (en) 2019-04-12
WO2016183280A1 (en) 2016-11-17
AU2016261913B2 (en) 2021-08-12
IL255527A (en) 2018-01-31
EP3294320A4 (en) 2018-12-26
TWI814187B (zh) 2023-09-01
TW202231294A (zh) 2022-08-16
IL284686B2 (en) 2023-05-01
IL255527B (en) 2021-07-29
MY189601A (en) 2022-02-18
AU2021258087B2 (en) 2023-04-27
KR102640198B1 (ko) 2024-02-23
US20180125928A1 (en) 2018-05-10
EP3294320A1 (en) 2018-03-21
CN107847562A (zh) 2018-03-27
IL284686B (en) 2023-01-01
HK1251157A1 (zh) 2019-01-25
JP2018520094A (ja) 2018-07-26
IL284686A (en) 2021-08-31
JP2021191755A (ja) 2021-12-16
TWI762444B (zh) 2022-05-01
KR20180006437A (ko) 2018-01-17
JOP20160092B1 (ar) 2023-03-28
CA2985777A1 (en) 2016-11-17

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