JP6974353B2 - 治療薬を送達するシステム及び方法 - Google Patents
治療薬を送達するシステム及び方法 Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/62—Plasma-deposition of organic layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/44—Applying ionised fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/02—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
- B05D3/0254—After-treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/14—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
- B05D3/141—Plasma treatment
- B05D3/145—After-treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/50—Multilayers
- B05D7/52—Two layers
- B05D7/54—No clear coat specified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
- B05D2401/30—Form of the coating product, e.g. solution, water dispersion, powders or the like the coating being applied in other forms than involving eliminable solvent, diluent or dispersant
- B05D2401/32—Form of the coating product, e.g. solution, water dispersion, powders or the like the coating being applied in other forms than involving eliminable solvent, diluent or dispersant applied as powders
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- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Radiology & Medical Imaging (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- General Preparation And Processing Of Foods (AREA)
Description
本出願は2016年2月1日出願の米国特許仮出願第62/289,545号に対する優先権の利益を主張し、その全体が本明細書に参照により組み込まれる。
その結果、プラズマ内の熱、電気、UV及び他の活性種が、分子の生物/薬学活性を破壊する不可逆化学及び/または構造変化を誘発できるので、研究者は、生体分子をプラズマ源に意図的に曝露することを多くの場合回避してきた。
Claims (15)
- コーティング基材の製造方法であって、
複数の乾燥粒子を非熱平衡プラズマに導入することであって、前記各粒子が医薬品を含み、前記医薬品がポリマーまたは生体分子ではない、導入することと、
基材を前記複数の乾燥粒子及び前記プラズマに曝露して、ポリマー、結合剤、または賦形剤を用いずに、前記医薬品を含む乾燥コーティングを前記基材上に付着させることと、を含み、前記基材が、組織、診断的要素、医療装置または食品から選択される、前記方法。 - 前記医薬品が抗生物質である、請求項1に記載の方法。
- 前記各粒子が、前記医薬品のみからなり、前記複数の乾燥粒子が、前記プラズマのアフターグロー領域内に導入される、請求項1または2に記載の方法。
- 前記コーティングが、前記医薬品の薬学活性を保持する、請求項1〜3のいずれか一項に記載の方法。
- 前記基材がマルチウェルプレートを含む、請求項1〜4のいずれか一項に記載の方法。
- 前記医薬品を含む前記複数の乾燥粒子が第1の複数の粒子であり、前記方法は、生体分子を含む第2の複数の乾燥粒子をプラズマに導入することをさらに含み、前記乾燥コーティングは、前記医薬品と前記生体分子を含む、請求項1、2、4、または5のいずれか一項に記載の方法。
- 前記コーティングが、前記医薬品を含む少なくとも1つの第1層と、前記生体分子を含む少なくとも1つの第2層と、を含み、前記少なくとも1つの第1層が前記少なくとも1つの第2層に隣接している、請求項1〜6のいずれか一項に記載の方法。
- 前記少なくとも1つの第1層は、50nm〜150nmの総厚を有する複数の第1層を含む、請求項7に記載の方法。
- 前記少なくとも1つの第2層の前記生体分子が架橋されている、請求項7に記載の方法。
- 前記医薬品を含む前記第1の複数の乾燥粒子が、前記プラズマの、前記生体分子を含む前記第2の複数の乾燥粒子とは異なる部分に導入される、請求項6〜9のいずれか一項に記載の方法。
- 前記第1の複数の乾燥粒子および/または前記第2の複数の乾燥粒子が前記プラズマのアフターグロー領域内に導入される、請求項6〜10のいずれか一項に記載の方法。
- 前記コーティングが、前記医薬品の均一層を前記基材表面上に含む、請求項1〜11のいずれか一項に記載の方法。
- 前記プラズマが、前記医薬品への前記基材の曝露中よりも、前記生体分子への前記基材の曝露中に、より強力な力を有する、請求項6〜12のいずれか一項に記載の方法。
- 前記医薬品が100℃未満の融点を有する、請求項1〜13のいずれか一項に記載の方法。
- 前記医薬品が60℃〜100℃の融点を有する、請求項1〜13のいずれか一項に記載の方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021180242A JP2022010008A (ja) | 2016-02-01 | 2021-11-04 | 治療薬を送達するシステム及び方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662289545P | 2016-02-01 | 2016-02-01 | |
US62/289,545 | 2016-02-01 | ||
PCT/US2017/015805 WO2017136334A1 (en) | 2016-02-01 | 2017-01-31 | Systems and methods for delivering therapeutic agents |
Related Child Applications (1)
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JP2021180242A Division JP2022010008A (ja) | 2016-02-01 | 2021-11-04 | 治療薬を送達するシステム及び方法 |
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JP2019510596A JP2019510596A (ja) | 2019-04-18 |
JP6974353B2 true JP6974353B2 (ja) | 2021-12-01 |
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JP2018559181A Active JP6974353B2 (ja) | 2016-02-01 | 2017-01-31 | 治療薬を送達するシステム及び方法 |
JP2021180242A Pending JP2022010008A (ja) | 2016-02-01 | 2021-11-04 | 治療薬を送達するシステム及び方法 |
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US (1) | US11772126B2 (ja) |
EP (1) | EP3411159A1 (ja) |
JP (2) | JP6974353B2 (ja) |
KR (1) | KR20180125461A (ja) |
CN (1) | CN109070137A (ja) |
WO (1) | WO2017136334A1 (ja) |
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EP3650580A1 (en) * | 2018-11-12 | 2020-05-13 | Molecular Plasma Group SA | Improved method for plasma immobilization of a biomolecule to a substrate via a linking molecule |
CN110693692A (zh) * | 2019-10-09 | 2020-01-17 | 华中科技大学 | 一种等离子体活化雾制备装置 |
EP4125542A4 (en) * | 2020-03-30 | 2024-04-03 | Frederick R Guy | PLASMA-GENERATED BRONCHOSCOPE AND METHOD FOR DESTRUCTING PATHOGENS AND HEALING LUNG TISSUES |
WO2023154752A1 (en) * | 2022-02-09 | 2023-08-17 | Theradep Technologies, Inc. | Methods of preparing coatings and related devices and systems |
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DE102008008614A1 (de) | 2008-02-12 | 2009-08-13 | Leibniz-Institut für Plasmaforschung und Technologie e.V. | Plama-Gerät zur selektiven Behandlung elektroporierter Zellen |
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WO2010002287A1 (ru) | 2008-07-03 | 2010-01-07 | Rogachev Andrey Gennadievich | Стеновая строительная конструкция |
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ES2764117T3 (es) * | 2010-12-13 | 2020-06-02 | Theradep Tech Inc | Dispositivos médicos implantables |
DK2666544T3 (en) * | 2012-05-24 | 2018-01-02 | Vito Nv | PROCEDURE FOR DEPOSITING AND CHARACTERIZING A COATING |
EP4129230A1 (en) * | 2013-01-22 | 2023-02-08 | Frederick Guy | Kit for tooth and bone restoration via plasma deposition |
US11690998B2 (en) | 2017-10-31 | 2023-07-04 | Theradep Technologies, Inc. | Methods of treating bacterial infections |
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JP2022010008A (ja) | 2022-01-14 |
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