JP2022010008A - 治療薬を送達するシステム及び方法 - Google Patents
治療薬を送達するシステム及び方法 Download PDFInfo
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- JP2022010008A JP2022010008A JP2021180242A JP2021180242A JP2022010008A JP 2022010008 A JP2022010008 A JP 2022010008A JP 2021180242 A JP2021180242 A JP 2021180242A JP 2021180242 A JP2021180242 A JP 2021180242A JP 2022010008 A JP2022010008 A JP 2022010008A
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- plasma
- coating
- activator
- substrate
- tissue
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- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/50—Multilayers
- B05D7/52—Two layers
- B05D7/54—No clear coat specified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
Description
本出願は2016年2月1日出願の米国特許仮出願第62/289,545号に対する優先権の利益を主張し、その全体が本明細書に参照により組み込まれる。
その結果、プラズマ内の熱、電気、UV及び他の活性種が、分子の生物/薬学活性を破壊する不可逆化学及び/または構造変化を誘発できるので、研究者は、生体分子をプラズマ源に意図的に曝露することを多くの場合回避してきた。
本開示において、例えば、以下の項目が提供される。
(項目1)
コーティング基材の製造方法であって、
複数の乾燥粒子を非熱平衡プラズマに導入することであって、前記各粒子が生体分子、医薬品またはそれらの組み合わせから選択される少なくとも1つの活性剤を含む、導入することと、
基材を前記複数の乾燥粒子及び前記プラズマに曝露して、前記少なくとも1つの活性剤を含むコーティングを前記基材上に付着させることと、を含む、前記方法。
(項目2)
前記各粒子が、前記少なくとも1つの活性剤のみからなる、項目1に記載の方法。
(項目3)
前記コーティングが、前記少なくとも1つの活性剤の生物活性または薬学活性を保持する、項目1または2に記載の方法。
(項目4)
前記基材が、組織、診断的要素、医療装置または食品から選択される、項目1~3のいずれか一項に記載の方法。
(項目5)
前記基材がマルチウェルプレートを含み、前記少なくとも1つの活性剤が生体分子を含む、項目1~4のいずれか一項に記載の方法。
(項目6)
前記コーティングが、医薬品を含む少なくとも1つの第1層と、生体分子を含む少なくとも1つの第2層と、を含み、前記少なくとも1つの第1層が前記少なくとも1つの第2層に隣接している、項目1~5のいずれか一項に記載の方法。
(項目7)
前記少なくとも1つの第2層の前記生体分子が架橋されている、項目6に記載の方法。
(項目8)
前記少なくとも1つの活性剤が第1活性剤と第2活性剤とを含み、前記複数の乾燥粒子を前記プラズマ内に導入することが、前記プラズマの異なる部分に前記第2活性剤より前記第1活性剤を導入することを含み、前記第1活性剤が生体分子であり、前記第2活性剤が医薬品である、項目1~7のいずれか一項に記載の方法。
(項目9)
前記複数の乾燥粒子が前記プラズマのアフターグロー領域内に導入される、項目1~8のいずれか一項に記載の方法。
(項目10)
コーティング基材の製造方法であって、
基材表面に少なくとも1つの活性剤を適用することであって、前記少なくとも1つの活性剤が生体分子、医薬品またはそれらの組み合わせから選択される、適用することと、
前記基材表面をプラズマのアフターグローに曝露して、前記少なくとも1つの活性剤を含む乾燥コーティングを形成することと、を含む、前記方法。
(項目11)
前記少なくとも1つの活性剤を適用することが、前記少なくとも1つの活性剤の均一層を前記基材表面上に形成することを含む、項目10に記載の方法。
(項目12)
前記少なくとも1つの活性剤が乾燥固体として適用される、項目10または11に記載の方法。
(項目13)
前記少なくとも1つの活性剤が少なくとも1つの溶媒の溶液中の前記基材表面に適用され、前記基材表面が前記プラズマへの曝露の前に乾燥する、項目10または11に記載の方法。
(項目14)
前記基材が、組織、診断的要素、または医療装置から選択される、項目10~13のいずれか一項に記載の方法。
(項目15)
前記乾燥コーティングが、前記少なくとも1つの活性剤の生物活性または薬学活性を保持する、項目10~14のいずれか一項に記載の方法。
(項目16)
コーティング基材の製造方法であって、
基材を医薬品及びプラズマに曝露して、前記基材上へ前記医薬品を含む少なくとも1つの第1層を付着させることであって、前記少なくとも1つの第1層が前記医薬品の薬学活性を保持する、曝露することと、
前記基材を生体分子及び前記プラズマに曝露して、コーティングを形成するために前記基材上へ生体分子を含む少なくとも1つの第2層を付着させることとであって、前記少なくとも1つの第2層が前記少なくとも1つの第1層と隣接する、曝露することと、を含み、
そこで前記少なくとも1つの第1層が医薬品の薬学活性を保持し、前記少なくとも第2層が生体分子の生物活性を保持する、前記方法。
(項目17)
前記医薬品または前記生体分子のうちの少なくとも1つが、乾燥粒子の形態で前記プラズマ内に導入される、項目16に記載の方法。
(項目18)
前記少なくとも1つの第1層が、50nm~150nmの範囲の総厚を有する、複数の前記第1層を含む、項目16または17に記載の方法。
(項目19)
前記基材が、組織、診断的要素、または医療装置から選択される、項目16~18のいずれか一項に記載の方法。
(項目20)
前記プラズマが、前記医薬品と前記プラズマへの前記基材の曝露より、前記生体分子と前記プラズマへの前記基材の曝露中により強力な力を有する、項目16~19のいずれか一項に記載の方法。
(項目21)
項目1~20のいずれか一項に記載のコーティングを含む、コーティング基材。
(項目22)
前記コーティング基材が診断的要素または医療装置である、項目21に記載のコーティング基材。
(項目23)
少なくとも1つの生体分子及び/または少なくとも1つの抗生物質を含む、項目21または22に記載のコーティング基材。
(項目24)
前記コーティングが、前記生体分子の生物活性及び/または前記抗生物質の抗生物質活性を保持する、項目23に記載のコーティング基材。
Claims (1)
- 本明細書に記載の発明。
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