JP6967528B2 - 抗補体Ｂｂ因子抗体及びその使用 - Google Patents

抗補体Ｂｂ因子抗体及びその使用 Download PDF

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Publication number
JP6967528B2
JP6967528B2 JP2018552076A JP2018552076A JP6967528B2 JP 6967528 B2 JP6967528 B2 JP 6967528B2 JP 2018552076 A JP2018552076 A JP 2018552076A JP 2018552076 A JP2018552076 A JP 2018552076A JP 6967528 B2 JP6967528 B2 JP 6967528B2
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antibody
seq
amino acid
acid sequence
antibodies
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JP2019513726A5 (enExample
JP2019513726A (ja
Inventor
サンディップ パニカー，
グラハム パリー，
カレン スー クリストファーソン，
トニー サンヨン ビュン，
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バイオベラティブ ユーエスエー インコーポレイテッド
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Publication of JP2019513726A publication Critical patent/JP2019513726A/ja
Publication of JP2019513726A5 publication Critical patent/JP2019513726A5/ja
Priority to JP2021147485A priority Critical patent/JP7326393B2/ja
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Publication of JP6967528B2 publication Critical patent/JP6967528B2/ja
Priority to JP2023126155A priority patent/JP2023139289A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018552076A 2016-04-04 2017-04-03 抗補体Ｂｂ因子抗体及びその使用 Active JP6967528B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021147485A JP7326393B2 (ja) 2016-04-04 2021-09-10 抗補体Ｂｂ因子抗体及びその使用
JP2023126155A JP2023139289A (ja) 2016-04-04 2023-08-02 抗補体Ｂｂ因子抗体及びその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317897P 2016-04-04 2016-04-04
US62/317,897 2016-04-04
PCT/US2017/025784 WO2017176651A1 (en) 2016-04-04 2017-04-03 Anti-complement factor bb antibodies and uses thereof

Related Child Applications (1)

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JP2021147485A Division JP7326393B2 (ja) 2016-04-04 2021-09-10 抗補体Ｂｂ因子抗体及びその使用

Publications (3)

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JP2019513726A JP2019513726A (ja) 2019-05-30
JP2019513726A5 JP2019513726A5 (enExample) 2020-05-07
JP6967528B2 true JP6967528B2 (ja) 2021-11-17

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JP2018552076A Active JP6967528B2 (ja) 2016-04-04 2017-04-03 抗補体Ｂｂ因子抗体及びその使用
JP2021147485A Active JP7326393B2 (ja) 2016-04-04 2021-09-10 抗補体Ｂｂ因子抗体及びその使用
JP2023126155A Pending JP2023139289A (ja) 2016-04-04 2023-08-02 抗補体Ｂｂ因子抗体及びその使用

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JP2021147485A Active JP7326393B2 (ja) 2016-04-04 2021-09-10 抗補体Ｂｂ因子抗体及びその使用
JP2023126155A Pending JP2023139289A (ja) 2016-04-04 2023-08-02 抗補体Ｂｂ因子抗体及びその使用

Country Status (23)

Country Link
US (3) US10934347B2 (enExample)
EP (1) EP3452510A4 (enExample)
JP (3) JP6967528B2 (enExample)
KR (2) KR20240096672A (enExample)
CN (2) CN109563158B (enExample)
AU (2) AU2017246794B2 (enExample)
BR (1) BR112018070357A2 (enExample)
CA (1) CA3019332A1 (enExample)
CL (1) CL2018002810A1 (enExample)
CO (1) CO2018010827A2 (enExample)
CR (1) CR20180529A (enExample)
DO (1) DOP2018000219A (enExample)
EA (1) EA201892225A1 (enExample)
EC (1) ECSP18082302A (enExample)
IL (3) IL311675A (enExample)
MA (1) MA44878A (enExample)
MX (2) MX2018012176A (enExample)
MY (1) MY194603A (enExample)
PE (1) PE20190209A1 (enExample)
PH (1) PH12018502137A1 (enExample)
SG (1) SG11201808525UA (enExample)
TN (1) TN2018000341A1 (enExample)
WO (1) WO2017176651A1 (enExample)

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EP3694874A1 (en) 2017-10-11 2020-08-19 Bioverativ USA Inc. Methods of inducing complement activity
JP7403165B2 (ja) 2017-12-19 2023-12-22 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 血液脳関門を通過してウイルスベクターを送達するための方法および組成物
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CA3147638A1 (en) * 2019-07-17 2021-01-21 Gemini Therapeutics Sub, Inc. Factor h potentiating antibodies and uses thereof
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JP7787164B2 (ja) 2020-09-23 2025-12-16 アキリオン ファーマシューティカルズ， インコーポレーテッド 補体媒介性障害の治療のための医薬化合物

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CO2018010827A2 (es) 2018-11-22
PE20190209A1 (es) 2019-02-07
PH12018502137A1 (en) 2019-09-23
CN109563158B (zh) 2022-08-09
CA3019332A1 (en) 2017-10-12
JP2023139289A (ja) 2023-10-03
KR20240096672A (ko) 2024-06-26
EP3452510A4 (en) 2020-01-15
JP2021191789A (ja) 2021-12-16
US20240228599A1 (en) 2024-07-11
EA201892225A1 (ru) 2019-09-30
ECSP18082302A (es) 2019-01-31
WO2017176651A1 (en) 2017-10-12
SG11201808525UA (en) 2018-10-30
IL295288B2 (en) 2024-08-01
CL2018002810A1 (es) 2019-03-15
KR102673420B1 (ko) 2024-06-07
US11851482B2 (en) 2023-12-26
TN2018000341A1 (en) 2020-06-15
IL262010A (en) 2018-10-31
US20210221877A1 (en) 2021-07-22
NZ747018A (en) 2025-05-02
AU2024224000A1 (en) 2024-12-19
MX2023007149A (es) 2023-06-28
KR20190003951A (ko) 2019-01-10
CN109563158A (zh) 2019-04-02
EP3452510A1 (en) 2019-03-13
BR112018070357A2 (pt) 2019-01-29
JP2019513726A (ja) 2019-05-30
US10934347B2 (en) 2021-03-02
MA44878A (fr) 2019-03-13
AU2017246794B2 (en) 2024-07-04
AU2017246794A1 (en) 2018-10-25
CN116790614A (zh) 2023-09-22
MX2018012176A (es) 2019-02-07
DOP2018000219A (es) 2019-03-31
US20190153079A1 (en) 2019-05-23
MY194603A (en) 2022-12-06
IL311675A (en) 2024-05-01
IL295288B1 (en) 2024-04-01
JP7326393B2 (ja) 2023-08-15
CR20180529A (es) 2019-03-21
IL295288A (en) 2022-10-01
IL262010B (en) 2022-09-01

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