JP6963508B2 - ループス腎炎を治療する組成物及び方法 - Google Patents

ループス腎炎を治療する組成物及び方法 Download PDF

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JP6963508B2
JP6963508B2 JP2017559119A JP2017559119A JP6963508B2 JP 6963508 B2 JP6963508 B2 JP 6963508B2 JP 2017559119 A JP2017559119 A JP 2017559119A JP 2017559119 A JP2017559119 A JP 2017559119A JP 6963508 B2 JP6963508 B2 JP 6963508B2
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JP2018515532A5 (enExample
JP2018515532A (ja
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ポール ブルネッタ，
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Genentech Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017559119A 2015-05-11 2016-05-10 ループス腎炎を治療する組成物及び方法 Active JP6963508B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021125267A JP2021185142A (ja) 2015-05-11 2021-07-30 ループス腎炎を治療する組成物及び方法
JP2023043873A JP2023088972A (ja) 2015-05-11 2023-03-20 ループス腎炎を治療する組成物及び方法
JP2025038039A JP2025106262A (ja) 2015-05-11 2025-03-11 ループス腎炎を治療する組成物及び方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562159876P 2015-05-11 2015-05-11
US62/159,876 2015-05-11
US201662300052P 2016-02-25 2016-02-25
US62/300,052 2016-02-25
PCT/US2016/031683 WO2016183104A1 (en) 2015-05-11 2016-05-10 Compositions and methods of treating lupus nephritis

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JP2018515532A JP2018515532A (ja) 2018-06-14
JP2018515532A5 JP2018515532A5 (enExample) 2019-06-13
JP6963508B2 true JP6963508B2 (ja) 2021-11-10

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JP2017559119A Active JP6963508B2 (ja) 2015-05-11 2016-05-10 ループス腎炎を治療する組成物及び方法
JP2021125267A Pending JP2021185142A (ja) 2015-05-11 2021-07-30 ループス腎炎を治療する組成物及び方法
JP2023043873A Withdrawn JP2023088972A (ja) 2015-05-11 2023-03-20 ループス腎炎を治療する組成物及び方法
JP2025038039A Pending JP2025106262A (ja) 2015-05-11 2025-03-11 ループス腎炎を治療する組成物及び方法

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JP2021125267A Pending JP2021185142A (ja) 2015-05-11 2021-07-30 ループス腎炎を治療する組成物及び方法
JP2023043873A Withdrawn JP2023088972A (ja) 2015-05-11 2023-03-20 ループス腎炎を治療する組成物及び方法
JP2025038039A Pending JP2025106262A (ja) 2015-05-11 2025-03-11 ループス腎炎を治療する組成物及び方法

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US (5) US20160346387A1 (enExample)
EP (4) EP4450524A3 (enExample)
JP (4) JP6963508B2 (enExample)
CN (2) CN107592812A (enExample)
HK (1) HK1248577A1 (enExample)
WO (1) WO2016183104A1 (enExample)

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US11149091B2 (en) * 2015-12-09 2021-10-19 Cedars-Sinai Medical Center Methods for treating nephrotic syndrome
US11865175B1 (en) 2017-04-28 2024-01-09 Cedars-Sinai Medical Center Post-transplantation prophylaxis and treatments for antibody-mediated rejection of solid organ transplant
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CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
JP2022547577A (ja) 2019-09-12 2022-11-14 ジェネンテック， インコーポレイテッド ループス腎炎を治療する組成物及び方法
CA3150482A1 (en) 2019-09-16 2021-03-25 Amgen Inc. Method for external sterilization of drug delivery device
CN111257445B (zh) * 2020-01-22 2022-09-09 上海交通大学医学院附属仁济医院 用于sle孕妇病情监测及其胎儿结局预测的产品及方法
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
WO2022198192A1 (en) * 2021-03-15 2022-09-22 Genentech, Inc. Compositions and methods of treating lupus nephritis
CA3234428A1 (en) * 2021-10-18 2023-04-27 Nader Najafian Use of complement factor d inhibitor for treatment of lupus nephritis and immunoglobulin a nephropathy
CN120168514A (zh) * 2025-03-21 2025-06-20 英百瑞(杭州)生物医药有限公司 Nk细胞在治疗系统性红斑狼疮中的应用

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