JP6963312B2 - 超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する - Google Patents

超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する Download PDF

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JP6963312B2
JP6963312B2 JP2018563056A JP2018563056A JP6963312B2 JP 6963312 B2 JP6963312 B2 JP 6963312B2 JP 2018563056 A JP2018563056 A JP 2018563056A JP 2018563056 A JP2018563056 A JP 2018563056A JP 6963312 B2 JP6963312 B2 JP 6963312B2
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nmr
mhz
cdcl
vinblastine
pharmaceutically acceptable
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JP2019520343A5 (enExample
JP2019520343A (ja
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デール エル ボジャー
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ザ スクリプス リサーチ インスティテュート
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2018563056A 2016-05-31 2017-05-30 超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する Expired - Fee Related JP6963312B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662343490P 2016-05-31 2016-05-31
US62/343,490 2016-05-31
PCT/US2017/035027 WO2017210206A1 (en) 2016-05-31 2017-05-30 Ultra-potent vina alkaloids: added molecular complexity further disrupts the tublin dimer-dimer interface

Publications (3)

Publication Number Publication Date
JP2019520343A JP2019520343A (ja) 2019-07-18
JP2019520343A5 JP2019520343A5 (enExample) 2020-07-09
JP6963312B2 true JP6963312B2 (ja) 2021-11-05

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JP2018563056A Expired - Fee Related JP6963312B2 (ja) 2016-05-31 2017-05-30 超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する

Country Status (5)

Country Link
US (1) US10975101B2 (enExample)
EP (1) EP3464289B1 (enExample)
JP (1) JP6963312B2 (enExample)
ES (1) ES2879679T3 (enExample)
WO (1) WO2017210206A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101868961B1 (ko) * 2016-06-21 2018-06-19 울산과학기술원 미세 유체 장치
CA2993378C (en) * 2017-09-15 2021-10-05 The Scripps Research Institute Vinblastine 20' amides: synthetic analogs that maintain or improve potency and simultaneously overcome pgp-derived efflux and resistance
CN111689985B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种含so2多杂环结构的化合物及其应用
CN111662298B (zh) * 2020-07-10 2021-08-10 北京燕化集联光电技术有限公司 一种含多杂环化合物及其在有机电致发光器件中的应用
CN111635420B (zh) * 2020-07-10 2022-05-13 北京燕化集联光电技术有限公司 一种新型多杂环化合物及其应用
CN111662309B (zh) * 2020-07-10 2021-11-09 北京燕化集联光电技术有限公司 一种多杂环结构化合物及其应用
CN111689989B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种含so2多杂环化合物及其应用
CN111747970B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种含so2多杂环的化合物及其应用
CN111689984B (zh) * 2020-07-10 2021-11-09 北京燕化集联光电技术有限公司 一种含多杂环结构的化合物及其应用
CN111689971B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种多杂环化合物及应用
CN111747961B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种含多杂环的化合物及应用
CN111662308B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种so2多杂环结构化合物及其应用
CN112341499B (zh) * 2020-11-05 2022-07-12 北京燕化集联光电技术有限公司 一种含硫有机电致磷光发光材料及其应用
CN112321647B (zh) * 2020-11-05 2022-08-16 北京燕化集联光电技术有限公司 一种含苯并咪唑结构的铱配合物及其应用
CN112175016B (zh) * 2020-11-05 2022-11-11 北京燕化集联光电技术有限公司 一种有机电致磷光发光材料及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
JP5542972B2 (ja) 2010-02-22 2014-07-09 ザ スクリプス リサーチ インスティテュート Ｍｄｒがん細胞に対する強化された生物活性を提供する１０’−フッ素化ビンカアルカロイド
EP2925760B1 (en) 2012-12-03 2018-02-21 The Scripps Research Institute C20'-substitited urea derivatives of vinca alkaloids
HU230462B1 (hu) * 2013-05-30 2016-07-28 Richter Gedeon Nyrt. Új bisz-indol alkaloidok mint rákellenes gyógyszerek
CA2993378C (en) 2017-09-15 2021-10-05 The Scripps Research Institute Vinblastine 20' amides: synthetic analogs that maintain or improve potency and simultaneously overcome pgp-derived efflux and resistance

Also Published As

Publication number Publication date
US10975101B2 (en) 2021-04-13
EP3464289A4 (en) 2019-12-25
JP2019520343A (ja) 2019-07-18
US20200317696A1 (en) 2020-10-08
EP3464289A1 (en) 2019-04-10
ES2879679T3 (es) 2021-11-22
EP3464289B1 (en) 2021-04-21
WO2017210206A1 (en) 2017-12-07

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