JP6960941B2 - 口腔内崩壊錠 - Google Patents
口腔内崩壊錠 Download PDFInfo
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- JP6960941B2 JP6960941B2 JP2018555237A JP2018555237A JP6960941B2 JP 6960941 B2 JP6960941 B2 JP 6960941B2 JP 2018555237 A JP2018555237 A JP 2018555237A JP 2018555237 A JP2018555237 A JP 2018555237A JP 6960941 B2 JP6960941 B2 JP 6960941B2
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| US20220387328A1 (en) * | 2021-06-04 | 2022-12-08 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Dosage form for nicotine replacement therapy |
| WO2023057879A1 (en) * | 2021-10-04 | 2023-04-13 | Neurim Pharmaceuticals (1991) Ltd. | Methods and products for treating subjects with autism spectrum disorders |
| CN120129530A (zh) | 2022-10-28 | 2025-06-10 | 阿斯利康(瑞典)有限公司 | 以40mg至240mg的剂量用于在治疗缺血事件中使用的重组腺苷三磷酸双磷酸酶蛋白 |
| CN116370423B (zh) * | 2023-02-28 | 2024-11-12 | 天津力生制药股份有限公司 | 一种替格瑞洛口腔崩解片及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB516834A (en) * | 1937-12-23 | 1940-01-12 | Charles Alexandre Nicolle | Improvements in or relating to packaging |
| DE2246013A1 (de) | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| GB0013407D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
| ES2268020T3 (es) * | 2001-05-10 | 2007-03-16 | Astellas Pharma Inc. | Comprimidos de disgregacion rapida de la cavidad oral y proceso para producir los mismos. |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| CN2717851Y (zh) | 2004-05-14 | 2005-08-17 | 重庆康刻尔制药有限公司 | 一种药品包装板 |
| TWI482772B (zh) | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物 |
| CN102058889A (zh) * | 2010-11-05 | 2011-05-18 | 王定豪 | 包含抗凝血类药物的分散片及其应用 |
| FR2968992B1 (fr) | 2010-12-16 | 2013-02-08 | Sanofi Aventis | Comprime pharmaceutique orodispersible a base de zolpidem |
| US20130160408A1 (en) | 2011-12-22 | 2013-06-27 | Gregor N. Neff | Blister Pack and Method |
| WO2013115171A1 (ja) | 2012-02-03 | 2013-08-08 | 旭化成ケミカルズ株式会社 | 苦味マスク顆粒含有口腔内崩壊錠 |
| CZ2012705A3 (cs) * | 2012-10-16 | 2014-04-23 | Zentiva, K.S. | Pevná orální farmaceutická formulace obsahující ticagrelor |
| CN103964066B (zh) * | 2013-02-06 | 2017-09-19 | 李和伟 | 一种冻干赋型制剂的包装装置 |
| WO2015110952A1 (en) | 2014-01-21 | 2015-07-30 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising ticagrelor or salt thereof |
| CN104650091B (zh) * | 2014-01-24 | 2016-10-05 | 福州乾正药业有限公司 | 替格瑞洛的微粉化及其晶型，以及制备方法和药物应用 |
| EA201691582A1 (ru) * | 2014-02-07 | 2017-01-30 | Оспекс Фармасьютикалз, Инк. | Новые фармацевтические препараты |
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