JP6960856B2 - ヒト化インフルエンザモノクローナル抗体およびその使用方法 - Google Patents

ヒト化インフルエンザモノクローナル抗体およびその使用方法 Download PDF

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JP6960856B2
JP6960856B2 JP2017553107A JP2017553107A JP6960856B2 JP 6960856 B2 JP6960856 B2 JP 6960856B2 JP 2017553107 A JP2017553107 A JP 2017553107A JP 2017553107 A JP2017553107 A JP 2017553107A JP 6960856 B2 JP6960856 B2 JP 6960856B2
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antibody
acid sequence
seq
binding
amino acid
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JP2018518940A5 (cg-RX-API-DMAC7.html
JP2018518940A (ja
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ウェイン エイ． マラスコ
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017553107A 2015-04-08 2016-04-08 ヒト化インフルエンザモノクローナル抗体およびその使用方法 Active JP6960856B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021083700A JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2023116535A JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144729P 2015-04-08 2015-04-08
US62/144,729 2015-04-08
PCT/US2016/026800 WO2016164835A1 (en) 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof

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JP2018518940A JP2018518940A (ja) 2018-07-19
JP2018518940A5 JP2018518940A5 (cg-RX-API-DMAC7.html) 2019-05-16
JP6960856B2 true JP6960856B2 (ja) 2021-11-05

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JP2017553107A Active JP6960856B2 (ja) 2015-04-08 2016-04-08 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2021083700A Pending JP2021121204A (ja) 2015-04-08 2021-05-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法
JP2023116535A Withdrawn JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

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JP2023116535A Withdrawn JP2023130499A (ja) 2015-04-08 2023-07-18 ヒト化インフルエンザモノクローナル抗体およびその使用方法

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US (2) US11135282B2 (cg-RX-API-DMAC7.html)
EP (1) EP3280730B1 (cg-RX-API-DMAC7.html)
JP (3) JP6960856B2 (cg-RX-API-DMAC7.html)
KR (1) KR102668588B1 (cg-RX-API-DMAC7.html)
CN (1) CN107750253B (cg-RX-API-DMAC7.html)
AU (2) AU2016246065B2 (cg-RX-API-DMAC7.html)
CA (1) CA2981969C (cg-RX-API-DMAC7.html)
IL (2) IL254951B (cg-RX-API-DMAC7.html)
WO (1) WO2016164835A1 (cg-RX-API-DMAC7.html)

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US20180099040A1 (en) 2018-04-12
CN107750253A (zh) 2018-03-02
IL254951B (en) 2021-09-30
KR102668588B1 (ko) 2024-05-22
CA2981969C (en) 2023-12-05
JP2021121204A (ja) 2021-08-26
EP3280730B1 (en) 2024-01-03
AU2021225240A1 (en) 2021-09-30
AU2016246065A1 (en) 2017-10-26
WO2016164835A1 (en) 2016-10-13
IL254951A0 (en) 2017-12-31
CA2981969A1 (en) 2016-10-13
US12076390B2 (en) 2024-09-03
AU2016246065B2 (en) 2021-06-03
IL286208A (en) 2021-10-31
CN107750253B (zh) 2022-10-04
US11135282B2 (en) 2021-10-05
US20220054624A1 (en) 2022-02-24
EP3280730C0 (en) 2024-01-03
JP2018518940A (ja) 2018-07-19
KR20170133507A (ko) 2017-12-05
JP2023130499A (ja) 2023-09-20
EP3280730A1 (en) 2018-02-14

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