JP6953494B2 - ヘプタデカトリエン側鎖のヒドロキノンの合成方法 - Google Patents
ヘプタデカトリエン側鎖のヒドロキノンの合成方法 Download PDFInfo
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- JP6953494B2 JP6953494B2 JP2019193894A JP2019193894A JP6953494B2 JP 6953494 B2 JP6953494 B2 JP 6953494B2 JP 2019193894 A JP2019193894 A JP 2019193894A JP 2019193894 A JP2019193894 A JP 2019193894A JP 6953494 B2 JP6953494 B2 JP 6953494B2
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- QDNKORPVEZWCAT-UHFFFAOYSA-N CC(Oc(cc1)cc(CCCCCCCCCCBr)c1OC(C)=O)=O Chemical compound CC(Oc(cc1)cc(CCCCCCCCCCBr)c1OC(C)=O)=O QDNKORPVEZWCAT-UHFFFAOYSA-N 0.000 description 1
- UEZRYNCKFMOHTF-UHFFFAOYSA-N CC(Oc(cc1CCCCCCCCCC=O)ccc1OC(C)=O)=O Chemical compound CC(Oc(cc1CCCCCCCCCC=O)ccc1OC(C)=O)=O UEZRYNCKFMOHTF-UHFFFAOYSA-N 0.000 description 1
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1,4−ジメトキシベンゼン(10g、72.4mmol)およびn−ブチルリチウム(5.8g、90.5mmol)を丸底フラスコに投入した。次に、溶媒のテトラヒドロフラン(200mL)を入れた後、丸底フラスコを低温反応器に入れ、−78℃で1時間攪拌した。その後、室温に移して1時間攪拌した。これとは別に追加で一口フラスコを準備し、1,10−ジブロモデカンを秤量した(65.17g、217.2mmol)。次に、この1,10−ジブロモデカンをテトラヒドロフラン(100mL)に溶解させて、この溶液を元の溶液にゆっくりと滴下し、室温で14時間攪拌した。その後、シリカゲルカラムで精製することにより、17gの2−(10'−ブロモインドリル)−1,4−ジメトキシベンゼン(式(1)に示す化合物)を生成物として回収した。収率は65%であった。
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