JP6910867B2 - Oral composition - Google Patents

Description

The present invention relates to oral compositions. More specifically, the present invention relates to a liquid oral composition containing an anionic surfactant.

In the oral composition, it is important to remove stains in the oral cavity and reduce the number of bacteria in the oral cavity. For this reason, surfactants (particularly anionic surfactants) are often incorporated into oral compositions. However, since surfactants, especially anionic surfactants, increase irritation to oral tissues, this irritation is required to obtain good usability even for consumers who are sensitive to irritation. (For example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2006-347987

An object of the present invention is to provide a liquid oral composition having an anionic surfactant but having low irritation.

The present inventors have found that a hypoallergenic oral composition can be obtained by adding polyoxyethylene hydrogenated castor oil to a liquid oral composition containing an anionic surfactant.

Further, in the oral composition, it is preferable that appropriate foaming occurs at the time of application to the oral cavity in order to enhance the feeling of use. However, when an anionic surfactant is added to a liquid oral composition, foaming tends to occur in the oral cavity during use, so that the foaming property becomes too high and a good feeling of use may not be obtained. By adjusting the amount of polyoxyethylene hydrogenated castor oil used, or by adding a specific thickener to the oral composition, the present inventors not only have preferable hypoallergenicity but also moderate degree. It was found that foaming property can also be obtained.

Then, based on these findings, further improvements have been made to complete the present invention.

The present invention includes, for example, the subjects described in the following sections.
Item 1.
(1) Anionic surfactant and
(2) A liquid oral composition containing polyoxyethylene hydrogenated castor oil.
Item 2.
Anionic surfactants include alkyl metal sulfates, polyoxyethylene alkyl ether sulfates (preferably sodium polyoxyethylene lauryl ether sulfate, sodium polyoxyethylene cocoyl ether sulfate, sodium lauryl sulfate and sodium cocoyl sulfate). Item 2. The liquid oral composition according to Item 1, which is at least one selected from the group consisting of an N-acylamino acid salt and an ester of phosphoric acid or sulfosuccinic acid and a polyethylene glycol ether of an aliphatic alcohol or a salt thereof. ..
Item 3.
Item 2. The anionic surfactant-containing liquid oral composition according to Item 1 or 2, further comprising (3) at least one polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, and carrageenan.
Item 4.
Item 3. The oral composition according to Item 3, which comprises at least an anionic surfactant, polyoxyethylene hydrogenated castor oil, and hyaluronic acid.
Item 5.
Item 4. The oral composition according to any one of Items 1 to 4, which is a liquid dentifrice, a mouthwash, a liquid, a spray, or a moisturizer.

According to the present invention, there is provided a liquid oral composition having both low irritation and appropriate foaming property.

The outline of the foaming test is shown.

The liquid oral composition according to the present invention contains (1) anionic surfactant and (2) polyoxyethylene hydrogenated castor oil. Further, it preferably contains (3) at least one polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, and carrageenan. Hereinafter, an anionic surfactant is a component (1), polyoxyethylene hydrogenated castor oil is a component (2), and at least one polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, and carrageenan is a component (3). Sometimes called.

Examples of the anionic surfactant include sulfate ester-based surfactants such as alkyl sulfate ester salts and polyoxyethylene alkyl ether sulfate ester salts; N-acylsarcosin salt, N-acylmethylalanine salt, and N-acyltaurine salt. Surfactants such as N-acylamino acids; carboxylic acid-based surfactants such as soaps and alkyl ether carboxylates; phosphate ester-based surfactants such as alkyl phosphates and polyoxyethylene alkyl phosphates, etc. Can be mentioned. Further, for example, an ester of phosphoric acid and a polyethylene glycol ether of an aliphatic alcohol or a salt thereof can also be mentioned. Further, for example, an ester of sulfosuccinic acid and a polyethylene glycol ether of an aliphatic alcohol or a salt thereof can also be mentioned. The ester may be a partial ester.

Among these, sulfate ester salts such as alkyl sulfate ester salts and polyoxyethylene alkyl ether sulfate ester salts, which are easy to obtain good cleanability, are preferably mentioned. As the alkyl group of the sulfate ester salt (particularly the alkyl sulfate ester salt or the polyoxyethylene alkyl ether sulfate ester salt), the sulfate ester salt is usually made from an alcohol derived from a vegetable oil made from coconut oil or palm kernel oil. , Alkyl chain lengths are often distributed, and such sulfate esters can be preferably used, and almost a single alkyl group (for example, 90% or more is a single alkyl group) can be used. It can also be used. In the present invention, from the viewpoint of obtaining low irritation to the oral cavity and preferable detergency, it is preferable to use an alkyl group having substantially excluded numbers having less than 10 carbon atoms and more than 18 carbon atoms. Further, an alkyl group having 10 to 18 carbon atoms is preferable, and an alkyl group having 12 to 16 carbon atoms is more preferable. Further, as the sulfate ester salt, a metal salt is preferable, and examples thereof include sodium salt, potassium salt, magnesium salt and the like. Of these, sodium salts are preferred. Preferred sulfate salts include, for example, sodium polyoxyethylene lauryl ether sulfate, sodium polyoxyethylene cocoyl ether sulfate, sodium lauryl sulfate and sodium cocoyl sulfate, and among them, sodium lauryl sulfate and sodium cocoyl sulfate are more preferable.

Further, as the N-acylamino acid salt, for example, sodium lauroyl sarcosine, sodium lauroyl methyl taurine and the like are preferably mentioned.

Further, as the aliphatic alcohol in the ester of phosphoric acid and the polyethylene glycol ether of the aliphatic alcohol or a salt thereof, the aliphatic alcohol having 9 to 18 carbon atoms is preferable, and the aliphatic alcohol having 10 to 16 carbon atoms is more preferable. , A fatty alcohol having 12 to 16 or 12 to 14 carbon atoms is more preferable. Further, the carbon chain can be linear or branched, and is preferably linear. The average number of moles of ethylene oxide added to the polyethylene glycol is preferably about 2 to 30, more preferably about 2 to 10, further preferably about 3 to 9, and even more preferably about 4 to 8. Further, as the salt, a metal salt is preferable, and examples thereof include a sodium salt, a potassium salt, a magnesium salt and the like, and among them, a sodium salt is preferable. More specifically, for example, (C12-16) Palace-6 phosphoric acid, (C12, 13) palace-2 sodium phosphate and the like can be mentioned.

Further, the polyethylene glycol ether of the aliphatic alcohol in the partial ester of the polyethylene glycol ether of the aliphatic alcohol and the sulfosuccinic acid or a salt thereof is preferably the same as that described above. Further, as the salt, a metal salt is preferable, and examples thereof include a sodium salt, a potassium salt, a magnesium salt and the like, and among them, a sodium salt is preferable. More specifically, for example, sulfosuccinic acid (C12-14) palace 6-2 sodium, sulfosuccinic acid (C12-14) s-palace 5 (or 7, 9, or 12) -2 sodium, and the like can be mentioned.

The anionic surfactant may be used alone or in combination of two or more.

When the anionic surfactant is a salt, in the present specification, the anionic surfactant of the salt (for example, an alkyl sulfate or a polyoxyethylene alkyl ether sulfate) is contained in the liquid oral composition. The term also includes the state in which the salt is ionized in the liquid oral composition.

The polyoxyethylene hydrogenated castor oil is not particularly limited, but the average number of moles of ethylene oxide added is preferably 5 to 200, more preferably 10 to 100, and even more preferably 20 to 80. , 40-80, more preferably 60, most preferably 60.

The liquid oral composition according to the present invention preferably contains a specific polysaccharide, and the polysaccharide is at least one selected from the group consisting of hyaluronic acid, alginic acid, and carrageenan (ingredients (ingredients (ingredients)). 3)). That is, these can be used alone or in combination of two or more. Of these, hyaluronic acid is preferable.

The average molecular weight of hyaluronic acid is generally hundreds of thousands to millions of daltons. The average molecular weight of hyaluronic acid used in the present invention is not particularly limited, but is preferably about 100,000 to 5 million daltons from the viewpoint of appropriate foaming property without excessive foaming and relaxation of irritation. The lower limit of the average molecular weight is preferably 200,000 daltons or more, more preferably 500,000 daltons or more, further preferably 600,000 daltons or more, further preferably 800,000 daltons or more, and particularly preferably 1 million daltons or more. The upper limit of the average molecular weight is not particularly limited, but is preferably 5 million daltons or less, more preferably 3 million daltons or less, and even more preferably 2 million daltons or less. The average molecular weight of hyaluronic acid is the "average molecular weight" in "Purified Sodium Hyaluronate" of the 17th revised Japanese Pharmacopoeia Manual (editor: Japanese Pharmacopoeia Manual Editor, first edition published on July 15, 2016). It is obtained by the method (viscosity method) described in the column.

Further, the term hyaluronic acid in the present specification also includes a salt of hyaluronic acid. The salt is not particularly limited, and examples thereof include sodium salt, potassium salt, calcium salt, zinc salt, magnesium salt, and ammonium salt. These hyaluronic acids can also be used by purchasing commercially available products. For example, "hyaluronic acid FCH" (Kikkoman Biochemifa Co., Ltd.), "hyaluronic acid HA-LF" (Kewpie Corp.), "hyaluronic acid LM" (Nippon Shinyaku Co., Ltd.) and the like can be used.

As used herein, alginic acid also includes salts of alginic acid. The salt is not particularly limited, and examples thereof include sodium salt, potassium salt, calcium salt, zinc salt, magnesium salt, and ammonium salt. In particular, it is preferable to use sodium alginate.

The alginic acid is not particularly limited, but the viscosity when 3 g is mixed with 300 mL of water (20 ° C., measured with a BL type rotational viscometer) is preferably 30 to 1500 mPa · s, preferably 100 to 1200 Pa · s. It is more preferably 300 to 800 Pa · s, and even more preferably 400 to 600 Pa · s.

As the carrageenan, any of λ, ι, and κ carrageenan can be used. Particularly, κ-carrageenan and ι-carrageenan are preferable.

Regarding the content ratio of each component in the liquid oral composition according to the present invention, the component (1) [anionic surfactant] is 10 parts by weight, and the component (2) [polyoxyethylene hydrogenated castor oil] is 2 to 60 parts by weight is preferable, 2.5 to 50 parts by weight is more preferable, 3 to 40 parts by weight is further preferable, 5 to 30 parts by weight is more preferable, and 10 to 20 parts by weight is particularly preferable. Further, the component (3) [at least one polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, and carrageenan] is preferably 0.1 to 10 parts by weight with respect to 10 parts by weight of the component (1). 0.2 to 5 parts by weight is more preferable, and 0.5 to 2 parts by weight is further preferable.

The liquid oral composition according to the present invention preferably contains both the components (2) and (3) in addition to the component (1) from the viewpoint of appropriate foaming property and preferable hypoallergenicity. .. Further, in this case, it is particularly preferable that at least polyoxyethylene hydrogenated castor oil and hyaluronic acid are contained.

When both the components (2) and (3) are included, the content weight ratio of the components (2) and (3) (component (2): component (3)) is about 100: 0.1 to 100. Is more preferable, about 100: 0.5 to 50 is more preferable, about 100: 1 to 20 is even more preferable, about 100: 2 to 10 is even more preferable, and about 100: 3 to 7 is particularly preferable. In addition, the content ratio of each liquid oral composition to the whole is preferably in the above-mentioned numerical range. The total content ratio of both the components (2) and (3) is preferably 0.1 to 55 parts by weight, more preferably 0.1 to 40 parts by weight, based on 10 parts by weight of the component (1). , 1 to 30 parts by weight, more preferably 5 to 25 parts by weight, still more preferably 10 to 23 parts by weight, and particularly preferably 12 to 21 parts by weight.

Further, particularly in the liquid oral composition of the present invention, the component (1) is preferably 0.05 to 0.5% by weight, more preferably 0.1 to 0.4% by weight, still more preferably 0.15. May contain up to 0.3% by weight. The component (2) is preferably 0.01 to 2% by weight or 0.01 to 1.5% by weight, more preferably 0.01 to 1% by weight, still more preferably 0.01 to 0.7% by weight. , More preferably 0.1 to 0.5% by weight, and particularly preferably 0.2 to 0.4% by weight. In particular, when the liquid oral composition according to the present invention does not contain the component (3), the component (2) is preferably contained in an amount of 0.2% by weight or more, preferably 0.2 to 2% by weight. It is more preferably contained in an amount of 0.4 to 2% by weight, further preferably contained in an amount of 0.5 to 1.5% by weight, and contained in an amount of 0.8 to 1.2% by weight. Is particularly preferable. The component (3) is preferably 0.001 to 0.5% by weight, more preferably 0.005 to 0.2% by weight, still more preferably 0.01 to 0.1% by weight, and even more preferably 0. It may contain from 0.01 to 0.05% by weight. The oral composition of the present invention is in a liquid state and does not include a state in which fluidity is lost (for example, in the form of a gel). Depending on the component used as the component (3), the gel may be formed even if the amount used is within the above range. Therefore, attention should be paid to the fluidity of the obtained oral composition. When hyaluronic acid is used as the component (3), its content is not particularly limited as long as it is in a liquid range, but for example, the upper limit of the content is preferably 0.45% by weight or less, and 0.4. It is more preferably 0% by weight or less, and further preferably 0.35% by weight or less.

In particular, in the present invention, by adding the above-mentioned specific polysaccharide, an appropriate foaming (suppressing excessive foaming) effect can be obtained. Since such polysaccharides are usually considered to prolong the life of the foam (more specifically, by strengthening the interface of the foam once formed, the foam itself is retained and hard to disappear), the specific polysaccharide is considered to be present. It is surprising that an appropriate foaming effect can be obtained by adding saccharides.

The liquid oral composition according to the present invention contains, as other components, known components that can be used in the oral composition, in addition to the above components (1) to (3), as long as the effects of the present invention are not impaired. Can be done. Examples of such other components include aqueous media, sweeteners, wetting agents, preservatives, pH adjusters, medicinal ingredients, cationic or nonionic surfactants, and the like. When a surfactant is used as another component, it should be noted that the effect of the present invention is not particularly impaired.

As the aqueous medium, water or a mixed solvent of water and ethanol is preferable, and water is more preferable. The liquid oral composition of the present invention is not particularly limited, but one containing no ethanol is more preferable.

Examples of sweeteners include saccharin, sodium saccharin, acesulfarm potassium, stevia extract, stebioside, neoheseridyldihydrocalcone, glycyrrhizin, perillartine, soumatin, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, etc. Examples include maltitol, xylitol, and lactitol. These sweeteners can be used alone or in combination of two or more.

Examples of the wetting agent include glycerin, ethylene glycol, propylene glycol, butanediol, pentanediol, hexanediol, sorbit, polyethylene glycol, polypropylene glycol, 1,2-octanediol, 1,8-octanediol, 2,3-. Octanediol, 2,4-octanediol, 2-ethyl-1,3-hexanediol, 2,2,4-trimethyl-1,3-pentanediol, 2,5-dimethyl-2,5-hexanediol, etc. Can be mentioned. These wetting agents can be used alone or in combination of two or more.

Examples of the preservative include benzoates such as sodium benzoate, paraoxybenzoic acid esters such as methylparaben and butylparaben, and phenols such as phenoxyethanol. These preservatives can be used alone or in combination of two or more. Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, aspartic acid, succinic acid, glucuronic acid, fumaric acid, glutamate, adipic acid, and salts thereof, as well as hydrochloric acid and water. Examples thereof include sodium oxide, potassium hydroxide and sodium silicate. These pH regulators can be used alone or in combination of two or more. The pH of the liquid oral composition according to the present invention is not particularly limited as long as it can be used in the oral cavity, but is generally preferably pH 3.0 or higher and 10.5 or lower, more preferably. Is pH 5.5 or more and 8.0 or less, more preferably pH 6.0 or more and 7.5 or less.

Medicinal ingredients include, for example, cationic bactericides such as cetylpyridinium chloride, chlorhexidine gluconate, benzethonium chloride, benzalkonium chloride, isopropylmethylphenol; amphoteric bactericides such as dodecyldiaminoethylglycine; dextranase, amylases, proteases. , Mutanase, lysoteam, enzymes such as lytic enzyme (lytecenzyme); glycyrrhizinate such as dipotassium glycyrrhizinate as anti-inflammatory agent; tranexamic acid, epsilonaminocaproic acid as anti-plasmin agent; ascorbic acid as bleeding improving agent; tissue Examples of the repair agent include allantin; and examples of the remineralizing agent include fluorine compounds such as sodium fluoride. In addition to the above, plant extracts extracted with a water-soluble solvent, chlorophyll, sodium chloride, zinc chloride and the like can also be mentioned. The medicinal ingredient can be used alone or in combination of two or more.

The form (dosage form) of the liquid oral composition according to the present invention means a fluid dosage form. Specifically, it includes liquids to viscous liquids. .. In the present invention, in particular, it can be a liquid oral composition such as a liquid dentifrice, a mouthwash, a liquid, a spray, and a moisturizer.

The liquid oral composition according to the present invention can be produced by a conventional method. That is, for example, it can be easily prepared by mixing an aqueous solvent and other components. More specifically, for example, it can be prepared by dispersing the components (2) and (3) in advance in the wetting agent, mixing them with an aqueous solvent, and further mixing other components. The total content of the aqueous solvent and the wetting agent with respect to the total amount of the liquid oral composition according to the present invention is, for example, preferably 80% by weight or more, more preferably 90% by weight or more, still more preferably 95% by weight or more. , 97% by weight or more is even more preferable. The upper limit is not particularly limited as long as the above components are contained, but is preferably 99.8% by mass or less, for example.

In addition, in this specification, "including" also includes "consisting essentially" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").

Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples.

Production Example A liquid oral composition (mouthwash) having the composition shown in Table 1 was prepared. Specifically, a polysaccharide dispersed in propylene glycol, polyoxyethylene hydrogenated castor oil, and other components are added to an appropriate amount of ion-exchanged water and mixed well, and then purified water is further added and mixed. I made a volumetric flask. The numbers in parentheses for the polyoxyethylene hydrogenated castor oil used in the table indicate the average number of moles of ethylene oxide added. Further, in the sodium carboxymethyl cellulose used, "low degree of etherification" indicates a degree of etherification of 0.5, and "high degree of etherification" indicates a degree of etherification of 1.2. The value of each component shown in Table 1 is% by weight.

The irritation and foaming properties of each composition thus obtained were evaluated by the following methods. In a liquid oral composition containing an anionic surfactant (particularly mouthwash), it is necessary to foam to some extent from the viewpoint of improving the removability of food residues and bacteria, but if it foams too much, It becomes difficult to wash the mouth (especially it becomes difficult to squeeze), and it becomes difficult to wash between the teeth when washing the mouth (if it foams too much, air will pass between the teeth when squeezing, so it is originally a mouthwash It is important to foam appropriately because the effect of the tooth cannot be obtained.

Irritation test J. Soc. Cosmet. Chem. Jpn. 28 (4) A hemoglobin denaturation test was performed according to the method described in 344-349 (1995), and the irritation of the oral composition of each example was evaluated. Specifically, hemoglobin was mixed with the oral composition of each example so as to have a final concentration of 0.025% by weight, incubated at 25 ° C. for 5 minutes, and then the absorbance at 418 nm was measured by the following formula. The hemoglobin denaturation rate (HDR value) was determined. The hemoglobin denaturation test is a test utilizing the fact that the absorbance of hemoglobin at 418 nm decreases when hemoglobin is denatured, and is widely used as a test for simply measuring the irritation of the ocular mucosa and the oral mucosa. It can be judged that the larger the hemoglobin denaturation rate, the stronger the irritation. In the test method, the numerical value may vary slightly depending on each test, but the value does not fluctuate significantly.

A hemoglobin denaturation rate of less than 25 was evaluated as ⊚, 25 or more and less than 30 was evaluated as ◯, and 30 or more was evaluated as x. The hemoglobin denaturation rate and the evaluation are also shown in Table 1.

Foaming test The height of the foam immediately after placing 5 g of each of the oral compositions in each case in a 15 mL tube and shaking at 330 rpm for 1 minute at a width of 5 cm (up to the top of the foam generated from the bottom of the tube; cm). Was measured.

A bubble height of less than 5.5 was evaluated as x, 5.5 or more and less than 7 was evaluated as ◯, 7 or more and less than 11 was evaluated as ⊚, 11 or more and less than 14 was evaluated as ◯, and 14 or more and less than 14 was evaluated as x. The foam height (cm) and the evaluation are also shown in Table 1.

Hereinafter, examples of formulation of the liquid oral composition according to the present invention will be given.

Prescription example 1 Mouthwash

Ingredient content
Glycerin 10
Propylene glycol 2
Polyoxyethylene (60) hardened castor oil 0.4
Sodium hyaluronate 0.02
Sodium lauryl sulfate 0.2
Methylparaben 0.2
Saccharin sodium 0.01
Sodium citrate 0.1
Fragrance 0.1
Purified water balance total 100

Prescription example 2 Mouthwash

Ingredient content
Sorbitol 10
Glycerin 5
Maltitol 5
Propylene glycol 2
Erythritol 2
Polyoxyethylene (80) hardened castor oil 0.3
Phenoxyethanol 0.3
Cocoyl (C12-C16) Sodium Sulfate 0.25
Citric acid 0.2
Sodium hyaluronate 0.1
Cetylpyridinium chloride 0.05
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance total 100

Prescription example 3 Mouthwash

Ingredient content
Glycerin 8
Ethanol 7
Polyoxyethylene (40) hardened castor oil 0.3
Sodium lauryl sulfate 0.25
Sucralose 2
Xylitol 2
Methylparaben 0.3
Citric acid 0.2
Cetylpyridinium chloride 0.05
Dipotassium glycyrrhizinate 0.04
Saccharin sodium 0.01
Sodium hyaluronate 0.008
Fragrance 0.1
Purified water balance total 100

Prescription example 4 mouthwash

Ingredient content
Glycerin 10
Propylene glycol 3
Polyoxyethylene (60) hardened castor oil 0.3
Methylparaben 0.3
Citric acid 0.2
Sodium lauryl sulfate 0.25
Isopropylmethylphenol 0.04
Sodium hyaluronate 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance total 100

Prescription example 5 Mouthwash

Ingredient content
Ethanol 10
Sorbitol 3
Polyoxyethylene (40) hardened castor oil 0.3
Methylparaben 0.3
Citric acid 0.2
Cocoyl (C12-C14) Sodium Sulfate 0.18
Thymol 0.1
l-menthol 0.1
Sodium hyaluronate 0.04
Saccharin sodium 0.01
Purified water balance total 100

Prescription example 6 Mouthwash

Ingredient content
Glycerin 10
Propylene glycol 2
Alkyl (C10-18) Sodium Sulfate 0.2
Sodium hyaluronate 0.06
Polyoxyethylene (60) hardened castor oil 0.2
Methylparaben 0.2
Saccharin sodium 0.01
Sodium citrate 0.1
Fragrance 0.1
Purified water balance total 100


Prescription example 7 Mouthwash

Ingredient content
Sorbitol 10
Glycerin 5
Maltitol 5
Propylene glycol 2
Erythritol 2
Polyoxyethylene (60) hardened castor oil 0.35
Cocoyl (C12-C14) Sodium Sulfate 0.2
Sodium hyaluronate 0.02
Phenoxyethanol 0.3
Citric acid 0.2
Cetylpyridinium chloride 0.05
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance total 100

Claims (5)

(1) Anionic surfactant ,
(2) Polyoxyethylene hydrogenated castor oil and
(3) looking contains hyaluronic acid or a salt thereof <br/>,
The content weight ratio of the components (2) and (3) is 100: 1 to 50, and the content is 100: 1 to 50.
The total content ratio of both the components (2) and (3) is 5 to 55 parts by weight with respect to 10 parts by weight of the component (1).
Liquid oral composition. (1) The anionic surfactant is an alkyl sulfate metal salt, a polyoxyethylene alkyl ether sulfate ester salt, an N-acyl amino acid salt, and an ester of phosphoric acid or sulfosuccinic acid and an aliphatic alcohol polyethylene glycol ether, or an ester thereof. The liquid oral composition according to claim 1, which is at least one selected from the group consisting of salts. (1) contains 0.05 to 0.5% by weight, (2) contains 0.01 to 2% by weight, and (3) contains 0.001 to 0.5% by weight, and
The content weight ratio of the components (2) and (3) is 100: 1 to 50, and the content is 100: 1 to 50.
The total content ratio of both the components (2) and (3) is 5 to 55 parts by weight with respect to 10 parts by weight of the component (1).
The liquid oral composition according to claim 1 or 2. Liquid dentifrices, mouthwashes, or a humectant, a liquid oral composition according to any one of claims 1 to 3. The liquid oral composition according to any one of claims 1 to 3, which is a liquid agent or a spray agent.

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