JP6903731B2 - 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 - Google Patents
強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 Download PDFInfo
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- JP6903731B2 JP6903731B2 JP2019500450A JP2019500450A JP6903731B2 JP 6903731 B2 JP6903731 B2 JP 6903731B2 JP 2019500450 A JP2019500450 A JP 2019500450A JP 2019500450 A JP2019500450 A JP 2019500450A JP 6903731 B2 JP6903731 B2 JP 6903731B2
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- substituted
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- 0 CCC*C(*C(NC1)=CC=C1C1=CC=CC=CC=CC=CC=CC=C1)=O Chemical compound CCC*C(*C(NC1)=CC=C1C1=CC=CC=CC=CC=CC=CC=C1)=O 0.000 description 5
- IFMORUNBRIRXLF-RZSVFLSASA-N C/N=C\C=C/C=C Chemical compound C/N=C\C=C/C=C IFMORUNBRIRXLF-RZSVFLSASA-N 0.000 description 1
- NNLOCKPMVPEAAF-QBJFVVIPSA-N CCN(C)C/C(/C=C\C)=C(\C)/C=C Chemical compound CCN(C)C/C(/C=C\C)=C(\C)/C=C NNLOCKPMVPEAAF-QBJFVVIPSA-N 0.000 description 1
- ZHHTYTDZEMZYOZ-UHFFFAOYSA-N CN(CCN1c(cc2)ccc2C(c2ccccc22)=NNC2=O)C1=O Chemical compound CN(CCN1c(cc2)ccc2C(c2ccccc22)=NNC2=O)C1=O ZHHTYTDZEMZYOZ-UHFFFAOYSA-N 0.000 description 1
- YIRAUZOICMUAQR-UHFFFAOYSA-N CN1N=C(c(cc2)ccc2N(CC(c2ccccc2)O2)C2=O)c(cccc2)c2C1=O Chemical compound CN1N=C(c(cc2)ccc2N(CC(c2ccccc2)O2)C2=O)c(cccc2)c2C1=O YIRAUZOICMUAQR-UHFFFAOYSA-N 0.000 description 1
- VIYQODYZRGGKJF-UHFFFAOYSA-N CN1N=C(c(cc2)ccc2N(CCC2C(N(C3)Cc4c3cccc4)=O)C2=O)c(cccc2)c2C1=O Chemical compound CN1N=C(c(cc2)ccc2N(CCC2C(N(C3)Cc4c3cccc4)=O)C2=O)c(cccc2)c2C1=O VIYQODYZRGGKJF-UHFFFAOYSA-N 0.000 description 1
- QUKKRSFVDPIFEL-UHFFFAOYSA-N COc1ccccc1NC(CCN1c(cc2)ccc2C(c2ccccc22)=NNC2=O)C1=O Chemical compound COc1ccccc1NC(CCN1c(cc2)ccc2C(c2ccccc22)=NNC2=O)C1=O QUKKRSFVDPIFEL-UHFFFAOYSA-N 0.000 description 1
- IPZUBKBAYXWIBL-UHFFFAOYSA-N Cc1cc(NC(CCN2c(cc3)ccc3C(c3ccccc33)=NNC3=O)C2=O)cc(OC)c1 Chemical compound Cc1cc(NC(CCN2c(cc3)ccc3C(c3ccccc33)=NNC3=O)C2=O)cc(OC)c1 IPZUBKBAYXWIBL-UHFFFAOYSA-N 0.000 description 1
- JAGCQTZNUQROMH-UHFFFAOYSA-N O=C(C(CC1)Nc2cc(OC(F)F)ccc2)N1c(cc1)ccc1C(c1ccccc11)=NNC1=O Chemical compound O=C(C(CC1)Nc2cc(OC(F)F)ccc2)N1c(cc1)ccc1C(c1ccccc11)=NNC1=O JAGCQTZNUQROMH-UHFFFAOYSA-N 0.000 description 1
- HDRNNUSDYFMXMS-UHFFFAOYSA-N O=C1N(c(cc2)ccc2C(c2ccccc22)=NNC2=O)N=CN1Cc1cc(OC(F)F)ccc1 Chemical compound O=C1N(c(cc2)ccc2C(c2ccccc22)=NNC2=O)N=CN1Cc1cc(OC(F)F)ccc1 HDRNNUSDYFMXMS-UHFFFAOYSA-N 0.000 description 1
- CWUQIEBYZXRBCI-UHFFFAOYSA-N O=C1N(c(cc2)ccc2C(c2ccccc22)=NNC2=O)N=CN1Cc1cccc(F)c1 Chemical compound O=C1N(c(cc2)ccc2C(c2ccccc22)=NNC2=O)N=CN1Cc1cccc(F)c1 CWUQIEBYZXRBCI-UHFFFAOYSA-N 0.000 description 1
- PHNXYQCFZAMNIX-UHFFFAOYSA-N O=C1OCC(c2ccccc2)N1c(cc1)ccc1C(c1ccccc11)=NNC1=O Chemical compound O=C1OCC(c2ccccc2)N1c(cc1)ccc1C(c1ccccc11)=NNC1=O PHNXYQCFZAMNIX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
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- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021103777A JP7225317B2 (ja) | 2016-07-07 | 2021-06-23 | 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359341P | 2016-07-07 | 2016-07-07 | |
| US62/359,341 | 2016-07-07 | ||
| PCT/US2017/040846 WO2018009622A1 (en) | 2016-07-07 | 2017-07-06 | Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103777A Division JP7225317B2 (ja) | 2016-07-07 | 2021-06-23 | 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520402A JP2019520402A (ja) | 2019-07-18 |
| JP2019520402A5 JP2019520402A5 (enExample) | 2020-08-13 |
| JP6903731B2 true JP6903731B2 (ja) | 2021-07-14 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500450A Active JP6903731B2 (ja) | 2016-07-07 | 2017-07-06 | 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 |
| JP2021103777A Active JP7225317B2 (ja) | 2016-07-07 | 2021-06-23 | 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103777A Active JP7225317B2 (ja) | 2016-07-07 | 2021-06-23 | 強力で選択的なｒｏｃｋ阻害剤としてのラクタム、環状尿素、およびカルバメート、およびトリアゾロン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10730858B2 (enExample) |
| EP (1) | EP3481816B1 (enExample) |
| JP (2) | JP6903731B2 (enExample) |
| KR (1) | KR102473481B1 (enExample) |
| CN (1) | CN110049977B (enExample) |
| ES (1) | ES2814325T3 (enExample) |
| WO (1) | WO2018009622A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| EP3464262B1 (en) | 2016-05-27 | 2020-02-26 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| ES2829550T3 (es) | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| CN110023291B (zh) | 2016-11-30 | 2023-07-18 | 百时美施贵宝公司 | 三环rho激酶抑制剂 |
| KR102680164B1 (ko) | 2017-07-12 | 2024-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | Rock 억제제로서의 페닐아세트아미드 |
| ES2894128T3 (es) | 2017-07-12 | 2022-02-11 | Bristol Myers Squibb Co | Inhibidores aminoheterocíclicos de cinco miembros y aminoheterocíclicos bicíclicos de 5,6 o 6,6 miembros de ROCK para el tratamiento de la insuficiencia cardíaca |
| KR102644889B1 (ko) | 2017-07-12 | 2024-03-06 | 브리스톨-마이어스 스큅 컴퍼니 | Rock 억제제로서의 스피로헵타닐 히단토인 |
| TW201908293A (zh) | 2017-07-12 | 2019-03-01 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之5員及雙環雜環醯胺 |
| US12060341B2 (en) | 2017-07-12 | 2024-08-13 | Bristol-Myers Squibb Company | Spiroheptanyl hydantoins as ROCK inhibitors |
| EP3704121B1 (en) | 2017-11-03 | 2022-12-21 | Bristol-Myers Squibb Company | Diazaspiro rock inhibitors |
| SI3877364T1 (sl) | 2018-11-06 | 2025-02-28 | Cervello Therapeutics, Llc | Inhibitorji rock kinaze |
| US11248004B2 (en) | 2018-11-06 | 2022-02-15 | Cervello Therapeutics, Llc. | Substituted isoquinolines as rock kinase inhibitors |
| TW202122382A (zh) * | 2019-09-06 | 2021-06-16 | 日商小野藥品工業股份有限公司 | 乙內醯脲衍生物 |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| TW202216713A (zh) | 2020-07-02 | 2022-05-01 | 美商英塞特公司 | 作為ｊａｋ２ ｖ６１７ｆ抑制劑之三環脲化合物 |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| EP4298099A1 (en) | 2021-02-25 | 2024-01-03 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| FI4426434T3 (fi) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Pparg:n käänteisagonisteja ja niiden käyttöjä |
| JPWO2023085369A1 (enExample) | 2021-11-11 | 2023-05-19 | ||
| PE20251706A1 (es) | 2022-03-17 | 2025-07-02 | Incyte Corp | Compuestos de urea triciclica como inhibidores de v617f de jak2 |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080275062A1 (en) | 2004-01-30 | 2008-11-06 | David Harold Drewry | Chemical Compounds |
| JP2008514636A (ja) | 2004-09-28 | 2008-05-08 | アンジオン バイオメディカ コーポレイション | サイトカイン活性の低分子モジュレーター |
| SI2120579T1 (sl) * | 2006-12-28 | 2014-03-31 | Abbvie Inc. | Inhibitorji poli (adp-riboze)polimeraze |
| EA033220B1 (ru) * | 2013-01-18 | 2019-09-30 | Бристол-Майерс Сквибб Компани | Фталазиноны и изохинолиноны в качестве ингибиторов rock |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| DK2986611T3 (da) | 2013-04-18 | 2019-05-06 | Shanghai Fochon Pharmaceutical Co Ltd | Bestemte proteinkinaseinhibitorer |
| TW201506024A (zh) | 2013-07-02 | 2015-02-16 | 必治妥美雅史谷比公司 | 作為有效ｒｏｃｋ抑制劑的三環甲醯胺衍生物 |
| CN105518005B (zh) | 2013-07-02 | 2018-07-20 | 百时美施贵宝公司 | 作为rock抑制剂的三环吡啶-甲酰胺衍生物 |
| US9902702B2 (en) | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| ES2838573T3 (es) | 2014-08-21 | 2021-07-02 | Bristol Myers Squibb Co | Derivados de benzamida ligados como inhibidores potentes de ROCK |
| ES2815681T3 (es) | 2015-01-09 | 2021-03-30 | Bristol Myers Squibb Co | Ureas cíclicas como inhibidores de ROCK |
| EP3268360B1 (en) | 2015-03-09 | 2019-04-24 | Bristol-Myers Squibb Company | Lactams as inhibitors of rock |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| EP3464262B1 (en) | 2016-05-27 | 2020-02-26 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| ES2829550T3 (es) | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
| CN110023291B (zh) | 2016-11-30 | 2023-07-18 | 百时美施贵宝公司 | 三环rho激酶抑制剂 |
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2017
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- 2017-07-06 CN CN201780054580.4A patent/CN110049977B/zh active Active
- 2017-07-06 WO PCT/US2017/040846 patent/WO2018009622A1/en not_active Ceased
- 2017-07-06 KR KR1020197003126A patent/KR102473481B1/ko active Active
- 2017-07-06 ES ES17740240T patent/ES2814325T3/es active Active
- 2017-07-06 JP JP2019500450A patent/JP6903731B2/ja active Active
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| WO2018009622A1 (en) | 2018-01-11 |
| KR20190025960A (ko) | 2019-03-12 |
| JP7225317B2 (ja) | 2023-02-20 |
| EP3481816B1 (en) | 2020-06-24 |
| CN110049977A (zh) | 2019-07-23 |
| JP2019520402A (ja) | 2019-07-18 |
| KR102473481B1 (ko) | 2022-12-01 |
| CN110049977B (zh) | 2022-01-18 |
| JP2021152061A (ja) | 2021-09-30 |
| US20190300510A1 (en) | 2019-10-03 |
| US10730858B2 (en) | 2020-08-04 |
| ES2814325T3 (es) | 2021-03-26 |
| EP3481816A1 (en) | 2019-05-15 |
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