JP6902097B2 - 遅延放出送達系及び方法 - Google Patents
遅延放出送達系及び方法 Download PDFInfo
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- JP6902097B2 JP6902097B2 JP2019522459A JP2019522459A JP6902097B2 JP 6902097 B2 JP6902097 B2 JP 6902097B2 JP 2019522459 A JP2019522459 A JP 2019522459A JP 2019522459 A JP2019522459 A JP 2019522459A JP 6902097 B2 JP6902097 B2 JP 6902097B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0279—Porous; Hollow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/623—Coating mediated by organosilicone compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/624—Coated by macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/652—The particulate/core comprising organic material
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Description
(a)表面細孔を有しており、かつその中に吸収された液体を有する、少なくとも1種の親水性コア粒子を用意する工程と、
(b)(a)の粒子と液状ポリマーとを、少なくともこの1種の粒子がこの液状ポリマーによってカプセル封入されて、少なくとも1種の処理済み粒子が形成されるに十分な時間、接触させる工程であって、液状ポリマーが、疎水性主鎖及び複数の親水性側鎖を有しており、親水性側鎖に隣接する親水性コア粒子上の表面細孔のうちの少なくとも一部が、水の存在下で閉塞され、水の非存在下で閉塞が解かれる工程と、
(c)化粧品として許容可能な水含有ビヒクル中に、少なくとも1種の処理済み粒子を分散させる工程と、を含む。
(a)多孔性コア粒子を用意する工程と、
(b)多孔性コア粒子と液体とを、液体と多孔性コア粒子との重量比が少なくとも約400:1で、液体がコア粒子内に吸収されるのに十分な条件下で接触させる工程と、
を含む。
本発明の遅延放出送達系は、内部に吸収された液体を有する、多孔性粒子を含む。
(a)表面細孔及び内部に吸収された液体を有する、少なくとも1種の親水性コア粒子を用意する工程と、
(b)(a)の粒子と液状ポリマーとを、この少なくとも1種の粒子がこの液状ポリマーによってカプセル封入されて、少なくとも1種の処理済み粒子が形成されるほど十分な条件下で、接触させる工程であって、液状ポリマーが、疎水性主鎖及び複数の親水性側鎖を有しており、親水性側鎖に隣接する親水性コア粒子上の表面細孔のうちの少なくとも一部が、水の存在下で閉塞され、水の非存在下で閉塞が解かれる工程と、
(c)化粧品として許容可能な水含有ビヒクル中に、少なくとも1種の処理済み粒子を分散させる工程と、
によって調製することができる。
(a)多孔性コア粒子を用意する工程と、
(b)多孔性コア粒子と液体とを、液体と多孔性コア粒子との重量比が少なくとも約400:1で、液体が多孔性コア粒子内に吸収されるのに十分な条件下で接触させる工程と、
によって調製することができる。
以下は、本発明の実施形態の一つである。
(1)少なくとも1種の処理済み粒子を含む遅延放出送達系であって、前記処理済み粒子は、表面細孔及び内部に含まれている液体を有する親水性コア粒子を含み、前記親水性コア粒子は、疎水性主鎖及び複数の親水性ペンダント基を有するポリマーによって更にカプセル封入されており、前記親水性ペンダント基に隣接する前記表面細孔の少なくとも一部が、水の存在下で閉塞され、水の非存在下で閉塞が解かれる、遅延放出送達系。
(2)前記ポリマーがシリコーン主鎖を含む、(1)に記載の遅延放出送達系。
(3)前記ポリマーがポリグリセロールペンダント基により修飾されている、(2)に記載の遅延放出送達系。
(4)前記液体が、水系、油系、水中油型エマルション、水中シリコーン型エマルション、油中水型エマルション、シリコーン中水型エマルション又は複数のエマルションである、(1)に記載の遅延放出送達系。
(5)前記液体が、フレグランスオイル、肌有益活性物、頭皮有益活性物、毛髪有益活性物、又はそれらの組合せを含む、(1)に記載の遅延放出送達系。
(6)前記液体及び前記処理済み粒子が適合可能な表面張力を有する、(1)に記載の遅延放出送達系。
(7)前記親水性コア粒子が、約100nm〜約50μmの平均粒子サイズを有するマイクロスフィアである、(1)に記載の遅延放出送達系。
(8)前記親水性コア粒子に、前記粒子の前記表面から前記コアまで広がる一連のマイクロ細孔が設けられている、(7)に記載の遅延放出送達系。
(9)水を含有する化粧品として許容可能なビヒクル中に、(1)に記載の遅延放出送達系を含む化粧用組成物。
(10)少なくとも1つの更なる肌、頭皮又は毛髪の有益成分を含む、(9)に記載の化粧用組成物。
Claims (8)
- 少なくとも1種の処理済み粒子を含む遅延放出送達系であって、前記処理済み粒子は、表面細孔及び内部に含まれている液体を有する親水性コア粒子を含み、前記親水性コア粒子は、疎水性主鎖及び複数の親水性ペンダント基を有するポリマーによって更にカプセル封入されており、
前記親水性ペンダント基に隣接する前記表面細孔の少なくとも一部が、水の存在下で閉塞され、水の非存在下で閉塞が解かれ、
前記ポリマーが、ポリグリセロールペンダント基により修飾されているシリコーン主鎖を含み、
前記親水性コア粒子が、シリカ、シリル化シリカ、及びケイ酸カルシウムからなる群から選択される無機物質から形成される、
遅延放出送達系。 - 前記液体が、水系、油系、水中油型エマルション、水中シリコーン型エマルション、油中水型エマルション、シリコーン中水型エマルション又は複数のエマルションである、請求項1に記載の遅延放出送達系。
- 前記液体が、フレグランスオイル、肌有益活性物、頭皮有益活性物、毛髪有益活性物、又はそれらの組合せを含む、請求項1に記載の遅延放出送達系。
- 前記液体及び前記処理済み粒子が適合可能な表面張力を有する、請求項1に記載の遅延放出送達系。
- 前記親水性コア粒子が、100nm〜50μmの平均粒子サイズを有するマイクロスフィアである、請求項1に記載の遅延放出送達系。
- 前記親水性コア粒子に、前記粒子の前記表面から前記コアまで広がる一連のマイクロ細孔が設けられている、請求項5に記載の遅延放出送達系。
- 水を含有する化粧品として許容可能なビヒクル中に、請求項1に記載の遅延放出送達系を含む化粧用組成物。
- 少なくとも1つの更なる肌、頭皮又は毛髪の有益成分を含む、請求項7に記載の化粧用組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662413227P | 2016-10-26 | 2016-10-26 | |
US62/413,227 | 2016-10-26 | ||
PCT/US2017/052916 WO2018080678A1 (en) | 2016-10-26 | 2017-09-22 | Delayed release delivery systems and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019533686A JP2019533686A (ja) | 2019-11-21 |
JP6902097B2 true JP6902097B2 (ja) | 2021-07-14 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2019522459A Active JP6902097B2 (ja) | 2016-10-26 | 2017-09-22 | 遅延放出送達系及び方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10363205B2 (ja) |
EP (1) | EP3532010B1 (ja) |
JP (1) | JP6902097B2 (ja) |
KR (1) | KR102270658B1 (ja) |
CN (1) | CN109890347B (ja) |
AU (1) | AU2017352302B2 (ja) |
CA (1) | CA3041789A1 (ja) |
ES (1) | ES2859726T3 (ja) |
WO (1) | WO2018080678A1 (ja) |
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- 2017-09-22 WO PCT/US2017/052916 patent/WO2018080678A1/en unknown
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- 2017-09-22 KR KR1020197013444A patent/KR102270658B1/ko active IP Right Grant
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- 2017-09-22 JP JP2019522459A patent/JP6902097B2/ja active Active
- 2017-09-22 EP EP17866337.3A patent/EP3532010B1/en active Active
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US20180110687A1 (en) | 2018-04-26 |
KR20190055846A (ko) | 2019-05-23 |
EP3532010A4 (en) | 2019-09-04 |
ES2859726T3 (es) | 2021-10-04 |
EP3532010B1 (en) | 2021-01-06 |
EP3532010A1 (en) | 2019-09-04 |
JP2019533686A (ja) | 2019-11-21 |
CA3041789A1 (en) | 2018-05-03 |
WO2018080678A1 (en) | 2018-05-03 |
KR102270658B1 (ko) | 2021-07-01 |
US10363205B2 (en) | 2019-07-30 |
CN109890347A (zh) | 2019-06-14 |
AU2017352302B2 (en) | 2020-09-10 |
AU2017352302A1 (en) | 2019-05-30 |
CN109890347B (zh) | 2023-10-31 |
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