JP6891173B2 - Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 - Google Patents

Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 Download PDF

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JP6891173B2
JP6891173B2 JP2018525702A JP2018525702A JP6891173B2 JP 6891173 B2 JP6891173 B2 JP 6891173B2 JP 2018525702 A JP2018525702 A JP 2018525702A JP 2018525702 A JP2018525702 A JP 2018525702A JP 6891173 B2 JP6891173 B2 JP 6891173B2
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JP2018538264A (ja
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デロベイド タミー
デロベイド タミー
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Psychiatry (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2018525702A 2015-11-17 2016-11-16 Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 Active JP6891173B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562256199P 2015-11-17 2015-11-17
US62/256,199 2015-11-17
PCT/US2016/062154 WO2017087445A1 (en) 2015-11-17 2016-11-16 Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity

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JP2018538264A JP2018538264A (ja) 2018-12-27
JP2018538264A5 JP2018538264A5 (https=) 2019-12-26
JP6891173B2 true JP6891173B2 (ja) 2021-06-18

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US (2) US10716788B2 (https=)
EP (2) EP4295910A3 (https=)
JP (1) JP6891173B2 (https=)
KR (1) KR102780243B1 (https=)
CN (1) CN108884076B (https=)
AU (1) AU2016357735B2 (https=)
BR (1) BR112018007517B1 (https=)
CL (1) CL2018001252A1 (https=)
DK (1) DK3377484T3 (https=)
ES (1) ES2964946T3 (https=)
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HR (1) HRP20231547T1 (https=)
HU (1) HUE064244T2 (https=)
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PH (1) PH12018500736A1 (https=)
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PL3371165T3 (pl) * 2015-11-04 2022-05-02 Merck Patent Gmbh Inhibitor btk do zastosowania w terapii rakowej
KR102780243B1 (ko) * 2015-11-17 2025-03-14 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물을 사용하여 다발성 경화증을 치료하는 방법
CN112313214A (zh) * 2018-06-19 2021-02-02 默克专利有限公司 1-(4-{[6-氨基-5-(4-苯氧基-苯基)-嘧啶-4-基氨基]-甲基}-4-氟代-哌啶-1-基)-丙烯酮及其盐形式的新晶体形式以及获得方法
MX2021000094A (es) * 2018-07-20 2021-03-25 Merck Patent Gmbh Compuesto de amino-pirimidina sustituido para usarse en un metodo para tratamiento y prevencion de esclerosis multiple.
EP4093397A1 (en) 2020-01-20 2022-11-30 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CN112250666B (zh) * 2020-10-09 2022-01-14 广东东阳光药业有限公司 取代的嘧啶类化合物及其用途
MX2023006418A (es) * 2020-12-02 2023-06-13 Telios Pharma Inc Metodos y composiciones para el tratamiento de una afeccion oftalmica.
AU2021398051A1 (en) 2020-12-10 2023-07-27 Principia Biopharma Inc. Crystal form of tolebrutinib, preparation method therefor and use thereof
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
CN119744171A (zh) 2022-06-24 2025-04-01 默克专利股份公司 自身免疫病和炎性疾病的治疗方案
CN117986236B (zh) * 2022-11-07 2024-12-31 天津征程医药科技有限公司 氘代的嘧啶衍生物以及包含该化合物的药物组合物
WO2025096900A1 (en) * 2023-11-03 2025-05-08 Board Of Regents, The University Of Texas System Synthetic network materials and methods of making and use thereof
US12414950B1 (en) * 2024-05-21 2025-09-16 Telios Pharma Inc. Methods of treating indolent systemic mastocytosis

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TWI372624B (en) 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
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KR20180084153A (ko) * 2011-06-10 2018-07-24 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
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KR102780243B1 (ko) * 2015-11-17 2025-03-14 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물을 사용하여 다발성 경화증을 치료하는 방법

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AU2016357735B2 (en) 2021-01-14
CL2018001252A1 (es) 2018-08-17
PT3377484T (pt) 2023-12-14
DK3377484T3 (da) 2023-11-27
JP2018538264A (ja) 2018-12-27
MY199473A (en) 2023-10-31
EP3377484A1 (en) 2018-09-26
CN108884076B (zh) 2021-07-30
RU2018120151A (ru) 2019-12-18
IL258978A (en) 2018-07-31
US20200316068A1 (en) 2020-10-08
KR102780243B1 (ko) 2025-03-14
BR112018007517A2 (pt) 2018-10-23
ES2964946T3 (es) 2024-04-10
RS64908B1 (sr) 2023-12-29
UA123159C2 (uk) 2021-02-24
HRP20231547T1 (hr) 2024-03-15
RU2018120151A3 (https=) 2020-03-24
MX2018005463A (es) 2018-08-01
US10716788B2 (en) 2020-07-21
KR20180080243A (ko) 2018-07-11
US20170136018A1 (en) 2017-05-18
WO2017087445A1 (en) 2017-05-26
EP4295910A2 (en) 2023-12-27
PH12018500736A1 (en) 2018-10-01
AU2016357735A1 (en) 2018-04-26
BR112018007517B1 (pt) 2023-09-26
LT3377484T (lt) 2023-12-27
NZ741294A (en) 2023-07-28
CN108884076A (zh) 2018-11-23
EP3377484B1 (en) 2023-09-06
ZA201802348B (en) 2020-08-26
FI3377484T3 (fi) 2023-11-30
HUE064244T2 (hu) 2024-02-28
EP4295910A3 (en) 2024-03-20
PL3377484T3 (pl) 2024-04-08
CA3002224A1 (en) 2017-05-26
MX386146B (es) 2025-03-18
SI3377484T1 (sl) 2024-02-29
IL258978B (en) 2021-04-29

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