CN108884076B - 使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 - Google Patents

使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 Download PDF

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CN108884076B
CN108884076B CN201680078780.9A CN201680078780A CN108884076B CN 108884076 B CN108884076 B CN 108884076B CN 201680078780 A CN201680078780 A CN 201680078780A CN 108884076 B CN108884076 B CN 108884076B
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multiple sclerosis
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CN108884076A (zh
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T·德罗瓦德
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201680078780.9A 2015-11-17 2016-11-16 使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 Active CN108884076B (zh)

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US201562256199P 2015-11-17 2015-11-17
US62/256,199 2015-11-17
PCT/US2016/062154 WO2017087445A1 (en) 2015-11-17 2016-11-16 Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity

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CN108884076B true CN108884076B (zh) 2021-07-30

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US (2) US10716788B2 (https=)
EP (2) EP4295910A3 (https=)
JP (1) JP6891173B2 (https=)
KR (1) KR102780243B1 (https=)
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CN117986236B (zh) * 2022-11-07 2024-12-31 天津征程医药科技有限公司 氘代的嘧啶衍生物以及包含该化合物的药物组合物
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KR102780243B1 (ko) * 2015-11-17 2025-03-14 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물을 사용하여 다발성 경화증을 치료하는 방법

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CL2018001252A1 (es) 2018-08-17
PT3377484T (pt) 2023-12-14
DK3377484T3 (da) 2023-11-27
JP2018538264A (ja) 2018-12-27
MY199473A (en) 2023-10-31
EP3377484A1 (en) 2018-09-26
RU2018120151A (ru) 2019-12-18
IL258978A (en) 2018-07-31
US20200316068A1 (en) 2020-10-08
KR102780243B1 (ko) 2025-03-14
BR112018007517A2 (pt) 2018-10-23
ES2964946T3 (es) 2024-04-10
RS64908B1 (sr) 2023-12-29
UA123159C2 (uk) 2021-02-24
HRP20231547T1 (hr) 2024-03-15
RU2018120151A3 (https=) 2020-03-24
MX2018005463A (es) 2018-08-01
US10716788B2 (en) 2020-07-21
KR20180080243A (ko) 2018-07-11
US20170136018A1 (en) 2017-05-18
WO2017087445A1 (en) 2017-05-26
EP4295910A2 (en) 2023-12-27
PH12018500736A1 (en) 2018-10-01
AU2016357735A1 (en) 2018-04-26
BR112018007517B1 (pt) 2023-09-26
LT3377484T (lt) 2023-12-27
NZ741294A (en) 2023-07-28
CN108884076A (zh) 2018-11-23
JP6891173B2 (ja) 2021-06-18
EP3377484B1 (en) 2023-09-06
ZA201802348B (en) 2020-08-26
FI3377484T3 (fi) 2023-11-30
HUE064244T2 (hu) 2024-02-28
EP4295910A3 (en) 2024-03-20
PL3377484T3 (pl) 2024-04-08
CA3002224A1 (en) 2017-05-26
MX386146B (es) 2025-03-18
SI3377484T1 (sl) 2024-02-29
IL258978B (en) 2021-04-29

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