JP6883917B2 - 結晶性関節障害を処置するためのｃｘｃｒ−２阻害剤 - Google Patents

結晶性関節障害を処置するためのｃｘｃｒ−２阻害剤 Download PDF

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JP6883917B2
JP6883917B2 JP2018547929A JP2018547929A JP6883917B2 JP 6883917 B2 JP6883917 B2 JP 6883917B2 JP 2018547929 A JP2018547929 A JP 2018547929A JP 2018547929 A JP2018547929 A JP 2018547929A JP 6883917 B2 JP6883917 B2 JP 6883917B2
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compound
pharmaceutically acceptable
acceptable salt
sulfonamide
thio
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JP2019507791A5 (cg-RX-API-DMAC7.html
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ナナバティ，パヤル
マイナー，ジェフリー
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アルデア バイオサイエンシーズ インク．
アルデア バイオサイエンシーズ インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018547929A 2016-03-11 2017-03-09 結晶性関節障害を処置するためのｃｘｃｒ−２阻害剤 Expired - Fee Related JP6883917B2 (ja)

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JP2021078242A JP7126014B2 (ja) 2016-03-11 2021-05-05 結晶性関節障害を処置するためのｃｘｃｒ－２阻害剤

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US201662307348P 2016-03-11 2016-03-11
US62/307,348 2016-03-11
PCT/US2017/021570 WO2017156270A1 (en) 2016-03-11 2017-03-09 Cxcr-2 inhibitors for treating crystal arthropathy disorders

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JP2019507791A JP2019507791A (ja) 2019-03-22
JP2019507791A5 JP2019507791A5 (cg-RX-API-DMAC7.html) 2020-04-30
JP6883917B2 true JP6883917B2 (ja) 2021-06-09

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JP2021078242A Active JP7126014B2 (ja) 2016-03-11 2021-05-05 結晶性関節障害を処置するためのｃｘｃｒ－２阻害剤

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US (1) US10772886B2 (cg-RX-API-DMAC7.html)
EP (1) EP3426253A4 (cg-RX-API-DMAC7.html)
JP (2) JP6883917B2 (cg-RX-API-DMAC7.html)
CN (2) CN109152780B (cg-RX-API-DMAC7.html)
AU (1) AU2017231832B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018068393A2 (cg-RX-API-DMAC7.html)
CA (1) CA3017345A1 (cg-RX-API-DMAC7.html)
CO (1) CO2018010880A2 (cg-RX-API-DMAC7.html)
MX (1) MX386771B (cg-RX-API-DMAC7.html)
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX386771B (es) 2016-03-11 2025-03-19 Ardea Biosciences Inc Inhibidores de cxcr-2 para tratamiento de trastornos de artropatía por cristales.
CN111356675A (zh) * 2017-09-12 2020-06-30 阿迪亚生命科学公司 用于治疗病症的cxcr-2抑制剂
CN111727184B (zh) * 2018-01-11 2022-06-28 深圳嘉科生物科技有限公司 Cxcr2拮抗剂
EP3998256A4 (en) * 2019-07-11 2023-07-19 Shenzhen Optimum Biological Technology Co., Ltd CRYSTALLINE FORM OF CXCR2 ANTAGONIST AND ITS USE
KR102260478B1 (ko) * 2019-08-19 2021-06-02 연세대학교 산학협력단 일나트륨 요소화물 결정 용해용 조성물
US20230210792A1 (en) * 2020-06-05 2023-07-06 Aristea Therapeutics, Inc. Use of a combination of colchicine and a cxcr-2 inhibitors for the treatment or prevention of familial mediterranean fever (fmf) and flare-ups thereof
WO2022162021A1 (en) * 2021-01-27 2022-08-04 Astrazeneca Ab Verinurad compositions and methods of use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
PE20051093A1 (es) 2004-01-30 2006-01-16 Schering Corp Polimorfos cristalinos de un ligando receptor de cxc quimiocina
MX2007002240A (es) * 2004-08-28 2007-04-20 Astrazeneca Ab Derivados de pirimidinosulfonamida como moduladores del receptor quimiocina.
RU2009131454A (ru) 2007-01-19 2011-02-27 Такеда Фармасьютикалз Норт Америка, Инк. (Us) Способы предупреждения или уменьшения числа обострений подагры с применением ингибиторов ксантиноксидоредуктазы и противовоспалительных средств
EP2203432A4 (en) 2007-09-21 2011-04-27 Glaxosmithkline Llc PROCESSING METHOD
US20090093548A1 (en) 2007-10-05 2009-04-09 Mutual Pharmaceutical Company, Inc Colchine compositions and methods
US20110009482A1 (en) 2007-12-04 2011-01-13 Schering Corporation Methods of treating copd
WO2009117710A2 (en) 2008-03-20 2009-09-24 Carolus Therapeutics, Inc. Methods of treating inflammation
CA2730477A1 (en) 2008-07-16 2010-01-21 Astrazeneca Ab Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases
AU2009302473A1 (en) 2008-10-06 2010-04-15 Carolus Therapeutics, Inc. Methods of treating inflammation
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
WO2010056399A1 (en) 2008-11-17 2010-05-20 Incode Biopharmaceutics, Inc. Method and composition for modulating the immune system and various inflammatory conditions comprising complement depletors
US20110256130A1 (en) 2008-12-01 2011-10-20 Joshua Robert Schultz Methods of treating inflammatory disorders
WO2010071865A1 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
EP2421901B1 (en) 2009-04-24 2015-10-28 Tissue Tech, Inc. Compositions containing hc ha complex and methods of use thereof
CA2773978A1 (en) 2009-09-23 2011-03-31 Carolus Therapeutics, Inc. Methods of treating inflammation
WO2011116245A2 (en) 2010-03-19 2011-09-22 Carolus Therapeutics, Inc. Methods of treating inflammation
JP2013531027A (ja) 2010-07-13 2013-08-01 アストラゼネカ・アクチエボラーグ Ｎ−［２−［［（２，３−ジフルオロフェニル）メチル］チオ］−６−｛［（１ｒ，２ｓ）−２，３−ジヒドロキシ−１−メチルプロピル］オキシ｝−４−ピリミジニル］−１−アゼチジンスルホンアミドの新規結晶形態
EP2608672B1 (en) * 2010-08-23 2020-12-16 Syntrix Biosystems, Inc. Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
SG10201605619XA (en) * 2011-07-12 2016-08-30 Astrazeneca Ab N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator
ES2846789T3 (es) 2012-07-11 2021-07-29 Tissuetech Inc Composiciones que contienen complejos HC-HA/PTX3 y métodos de uso de los mismos
US20170320954A1 (en) 2014-11-17 2017-11-09 Medimmune Limited Therapeutic combinations and methods for treating neoplasia
US20180221312A1 (en) 2016-03-11 2018-08-09 Ardea Biosciences, Inc. Cxcr-2 inhibitors for treating disorders
MX386771B (es) 2016-03-11 2025-03-19 Ardea Biosciences Inc Inhibidores de cxcr-2 para tratamiento de trastornos de artropatía por cristales.
CN111356675A (zh) 2017-09-12 2020-06-30 阿迪亚生命科学公司 用于治疗病症的cxcr-2抑制剂

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CO2018010880A2 (es) 2018-10-22
US10772886B2 (en) 2020-09-15
CN109152780B (zh) 2021-10-01
US20180235964A1 (en) 2018-08-23
EP3426253A1 (en) 2019-01-16
CA3017345A1 (en) 2017-09-14
WO2017156270A1 (en) 2017-09-14
AU2017231832B2 (en) 2021-11-11
CN113893252A (zh) 2022-01-07
JP7126014B2 (ja) 2022-08-25
MX2018010946A (es) 2019-05-23
JP2021121600A (ja) 2021-08-26
MX386771B (es) 2025-03-19
EP3426253A4 (en) 2019-11-06
AU2017231832A1 (en) 2018-10-04
BR112018068393A2 (pt) 2019-01-15
JP2019507791A (ja) 2019-03-22
CN109152780A (zh) 2019-01-04

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