JP6878004B2 - リンパ形質細胞性リンパ腫を処置する方法 - Google Patents
リンパ形質細胞性リンパ腫を処置する方法 Download PDFInfo
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- JP6878004B2 JP6878004B2 JP2016539167A JP2016539167A JP6878004B2 JP 6878004 B2 JP6878004 B2 JP 6878004B2 JP 2016539167 A JP2016539167 A JP 2016539167A JP 2016539167 A JP2016539167 A JP 2016539167A JP 6878004 B2 JP6878004 B2 JP 6878004B2
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- 0 CC=CCCC1=CC(C*)=C*C1 Chemical compound CC=CCCC1=CC(C*)=C*C1 0.000 description 31
- BDRXIHMSZOYUAN-UHFFFAOYSA-N CC(C)C(N1CCN(C)CC1)=O Chemical compound CC(C)C(N1CCN(C)CC1)=O BDRXIHMSZOYUAN-UHFFFAOYSA-N 0.000 description 1
- TXDOUCCKKNGHST-UHFFFAOYSA-N CC(C)CNC(OC(C)(C)C)=O Chemical compound CC(C)CNC(OC(C)(C)C)=O TXDOUCCKKNGHST-UHFFFAOYSA-N 0.000 description 1
- CMKSIMIQKMUUFQ-UHFFFAOYSA-N CC(C)NC(CCN(CC1)CCN1C(C)=O)=O Chemical compound CC(C)NC(CCN(CC1)CCN1C(C)=O)=O CMKSIMIQKMUUFQ-UHFFFAOYSA-N 0.000 description 1
- TVPDUFYZGFIQEP-UHFFFAOYSA-N CC(C)NC1OC1 Chemical compound CC(C)NC1OC1 TVPDUFYZGFIQEP-UHFFFAOYSA-N 0.000 description 1
- HXTKDDGTKRUJOQ-UHFFFAOYSA-N CC(C)[n]1cnc(C)c1 Chemical compound CC(C)[n]1cnc(C)c1 HXTKDDGTKRUJOQ-UHFFFAOYSA-N 0.000 description 1
- KWZYIVBVTSOZDI-LSDHQDQOSA-N CC/C(/c1cc(C(Nc2cc(C(NC3C=C(C(F)(F)F)C(CN4CCN(CC)CC4)=CC3)=O)ccc2C)=O)cnc1)=C\ON Chemical compound CC/C(/c1cc(C(Nc2cc(C(NC3C=C(C(F)(F)F)C(CN4CCN(CC)CC4)=CC3)=O)ccc2C)=O)cnc1)=C\ON KWZYIVBVTSOZDI-LSDHQDQOSA-N 0.000 description 1
- TXIOGJHPPVXTOY-UHFFFAOYSA-N CCN1CCN(C)CC1 Chemical compound CCN1CCN(C)CC1 TXIOGJHPPVXTOY-UHFFFAOYSA-N 0.000 description 1
- NCLNFEVRVZLVSW-UHFFFAOYSA-N CCN1CCN(CN(C)C)CC1 Chemical compound CCN1CCN(CN(C)C)CC1 NCLNFEVRVZLVSW-UHFFFAOYSA-N 0.000 description 1
- ACWXIBRIGIGXQJ-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2C(N[IH]I)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2C(N[IH]I)=O)CC1 ACWXIBRIGIGXQJ-UHFFFAOYSA-N 0.000 description 1
- WYEWKJYUIYAODG-UHFFFAOYSA-N CCOC1CCOCC1 Chemical compound CCOC1CCOCC1 WYEWKJYUIYAODG-UHFFFAOYSA-N 0.000 description 1
- NQPTWMKTGPWPMX-UHFFFAOYSA-N CNC1CNC1 Chemical compound CNC1CNC1 NQPTWMKTGPWPMX-UHFFFAOYSA-N 0.000 description 1
- MMKGWMQCWJARLI-UHFFFAOYSA-N CNNC1OC1 Chemical compound CNNC1OC1 MMKGWMQCWJARLI-UHFFFAOYSA-N 0.000 description 1
- NZMMDVSZHKTASL-UHFFFAOYSA-N CSCNC1C=CC=NC1 Chemical compound CSCNC1C=CC=NC1 NZMMDVSZHKTASL-UHFFFAOYSA-N 0.000 description 1
- RIKMMFOAQPJVMX-UHFFFAOYSA-N Cc1c[nH]nc1 Chemical compound Cc1c[nH]nc1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1ccn[nH]1 Chemical compound Cc1ccn[nH]1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N c1n[nH]c2c1cccc2 Chemical compound c1n[nH]c2c1cccc2 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915684P | 2013-12-13 | 2013-12-13 | |
| US61/915,684 | 2013-12-13 | ||
| US201462036917P | 2014-08-13 | 2014-08-13 | |
| US62/036,917 | 2014-08-13 | ||
| PCT/US2014/070167 WO2015089481A2 (en) | 2013-12-13 | 2014-12-12 | Methods to treat lymphoplasmacytic lymphoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504595A JP2017504595A (ja) | 2017-02-09 |
| JP2017504595A5 JP2017504595A5 (cg-RX-API-DMAC7.html) | 2018-07-26 |
| JP6878004B2 true JP6878004B2 (ja) | 2021-05-26 |
Family
ID=53371973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539167A Active JP6878004B2 (ja) | 2013-12-13 | 2014-12-12 | リンパ形質細胞性リンパ腫を処置する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9908872B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3079682A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6878004B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014361800B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2932353A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015089481A2 (cg-RX-API-DMAC7.html) |
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|---|---|---|---|---|
| USRE50030E1 (en) | 2013-12-13 | 2024-07-02 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| WO2015089481A2 (en) | 2013-12-13 | 2015-06-18 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| CA3010631A1 (en) | 2016-01-13 | 2017-07-20 | Stora Enso Oyj | Processes for the preparation of 2,5-furandicarboxylic acid and intermediates and derivatives thereof |
| WO2017147700A1 (en) | 2016-03-01 | 2017-09-08 | Ontario Institute For Cancer Research (Oicr) | Inhibitors of wdr5 protein-protein binding |
| JP2019507179A (ja) | 2016-03-01 | 2019-03-14 | プロペロン セラピューティックス インコーポレイテッド | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
| AU2017363313B2 (en) * | 2016-11-22 | 2021-06-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
| EP3548479A1 (en) * | 2016-11-30 | 2019-10-09 | ARIAD Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| JP7167069B2 (ja) * | 2017-06-29 | 2022-11-08 | ライジェル ファーマシューティカルズ， インコーポレイテッド | キナーゼ阻害剤ならびに作製および使用のための方法 |
| CA3090275A1 (en) | 2018-02-14 | 2019-08-22 | Dana-Farber Cancer Institute, Inc. | Irak degraders and uses thereof |
| CN108707147A (zh) * | 2018-06-20 | 2018-10-26 | 桑文军 | 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
| KR102653681B1 (ko) | 2018-07-31 | 2024-04-03 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제 |
| TWI721624B (zh) | 2018-10-31 | 2021-03-11 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
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| WO2023183377A1 (en) | 2022-03-23 | 2023-09-28 | Rigel Pharmaceuticals, Inc. | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
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| WO2015069287A1 (en) | 2013-11-08 | 2015-05-14 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
| WO2015089481A2 (en) | 2013-12-13 | 2015-06-18 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| USRE50030E1 (en) | 2013-12-13 | 2024-07-02 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
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2014
- 2014-12-12 WO PCT/US2014/070167 patent/WO2015089481A2/en not_active Ceased
- 2014-12-12 AU AU2014361800A patent/AU2014361800B2/en not_active Ceased
- 2014-12-12 EP EP14869351.8A patent/EP3079682A4/en active Pending
- 2014-12-12 US US15/104,005 patent/US9908872B2/en active Active
- 2014-12-12 CA CA2932353A patent/CA2932353A1/en active Pending
- 2014-12-12 JP JP2016539167A patent/JP6878004B2/ja active Active
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2018
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| US10597387B2 (en) | 2020-03-24 |
| EP3079682A2 (en) | 2016-10-19 |
| AU2014361800A1 (en) | 2016-06-09 |
| AU2014361800B2 (en) | 2020-05-07 |
| WO2015089481A2 (en) | 2015-06-18 |
| US20160311807A1 (en) | 2016-10-27 |
| WO2015089481A3 (en) | 2015-10-29 |
| EP3079682A4 (en) | 2017-08-30 |
| CA2932353A1 (en) | 2015-06-18 |
| JP2017504595A (ja) | 2017-02-09 |
| US20180186780A1 (en) | 2018-07-05 |
| US9908872B2 (en) | 2018-03-06 |
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