JP6877424B2 - アルギニンジンジパインの阻害剤 - Google Patents

アルギニンジンジパインの阻害剤 Download PDF

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JP6877424B2
JP6877424B2 JP2018522933A JP2018522933A JP6877424B2 JP 6877424 B2 JP6877424 B2 JP 6877424B2 JP 2018522933 A JP2018522933 A JP 2018522933A JP 2018522933 A JP2018522933 A JP 2018522933A JP 6877424 B2 JP6877424 B2 JP 6877424B2
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carbonyl
compound
pharmaceutically acceptable
disease
group
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JP2018534300A5 (https=
JP2018534300A (ja
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アンドレイ コンラディ，
アンドレイ コンラディ，
スティーブン エス． ドミニー，
スティーブン エス． ドミニー，
キャシー シー． リンチ，
キャシー シー． リンチ，
クレッグ コバーン，
クレッグ コバーン，
ジョセフ ヴァッカ，
ジョセフ ヴァッカ，
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コーテクシーミー， インコーポレイテッド
コーテクシーミー， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018522933A 2015-11-09 2016-11-09 アルギニンジンジパインの阻害剤 Expired - Fee Related JP6877424B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562253039P 2015-11-09 2015-11-09
US62/253,039 2015-11-09
US201662338924P 2016-05-19 2016-05-19
US62/338,924 2016-05-19
PCT/US2016/061197 WO2017083433A1 (en) 2015-11-09 2016-11-09 Inhibitors of arginine gingipain

Publications (3)

Publication Number Publication Date
JP2018534300A JP2018534300A (ja) 2018-11-22
JP2018534300A5 JP2018534300A5 (https=) 2019-12-19
JP6877424B2 true JP6877424B2 (ja) 2021-05-26

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ID=58695180

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JP2018522933A Expired - Fee Related JP6877424B2 (ja) 2015-11-09 2016-11-09 アルギニンジンジパインの阻害剤

Country Status (6)

Country Link
US (1) US10906881B2 (https=)
EP (1) EP3374352A4 (https=)
JP (1) JP6877424B2 (https=)
CN (1) CN108602787A (https=)
CA (1) CA3004095A1 (https=)
WO (1) WO2017083433A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
CN110944637A (zh) 2017-05-10 2020-03-31 库特克希米公司 氨基吡啶化合物及其制备方法和使用方法
WO2020191348A1 (en) * 2019-03-21 2020-09-24 Cortexyme, Inc. Arginine gingipain inhibitors
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors
CN112608976B (zh) * 2020-12-18 2023-03-17 珠海市德灏生物科技有限公司 一种牙周致病菌感染标记物检测试剂盒和检测方法
US20250334585A1 (en) * 2021-07-13 2025-10-30 Keystone Bio, Inc. Diagnostics for porphyromonas gingivalis
CN116474096A (zh) * 2022-01-14 2023-07-25 中山大学附属口腔医院 靶向牙龈卟啉单胞菌RgpB在结直肠癌的治疗及预防中的应用

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JPH01163162A (ja) 1987-12-18 1989-06-27 Showa Denko Kk アミノ酸誘導体および酵素阻害剤
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JPH10508034A (ja) 1995-03-24 1998-08-04 モレキュメティックス リミテッド βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用
WO1996030396A1 (en) 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
GB9510264D0 (en) 1995-05-22 1995-07-19 Iaf Biochem Int Low molecular weight bicyclic-urea type thrombin inhibitors
US5827860A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5827866A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL119466A (en) 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
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AU4172397A (en) 1996-09-06 1998-03-26 Biochem Pharma Inc. Lactam inhibitors of thrombin
WO1999026925A1 (en) 1997-11-26 1999-06-03 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitors comprising heterocyclic amide compounds
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US20170014468A1 (en) 2014-04-29 2017-01-19 Cortexyme, Inc. Methods of use for therapeutics targeting the pathogen porphyromonas gingivalis
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CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂

Also Published As

Publication number Publication date
EP3374352A1 (en) 2018-09-19
EP3374352A4 (en) 2019-10-02
CN108602787A (zh) 2018-09-28
US10906881B2 (en) 2021-02-02
US20180334440A1 (en) 2018-11-22
JP2018534300A (ja) 2018-11-22
CA3004095A1 (en) 2017-05-18
WO2017083433A1 (en) 2017-05-18

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