CN108602787A - 精氨酸牙龈卟啉菌蛋白酶的抑制剂 - Google Patents

精氨酸牙龈卟啉菌蛋白酶的抑制剂 Download PDF

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Publication number
CN108602787A
CN108602787A CN201680073083.4A CN201680073083A CN108602787A CN 108602787 A CN108602787 A CN 108602787A CN 201680073083 A CN201680073083 A CN 201680073083A CN 108602787 A CN108602787 A CN 108602787A
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CN
China
Prior art keywords
carbonyl
compound
bases
pharmaceutically acceptable
disease
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680073083.4A
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English (en)
Chinese (zh)
Inventor
安德列·康纳迪
史蒂芬·S·多米尼
凯西·C·林奇
克雷格·科伯恩
约瑟夫·瓦卡
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Lakshmi Kutyk Co
Original Assignee
Lakshmi Kutyk Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lakshmi Kutyk Co filed Critical Lakshmi Kutyk Co
Publication of CN108602787A publication Critical patent/CN108602787A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680073083.4A 2015-11-09 2016-11-09 精氨酸牙龈卟啉菌蛋白酶的抑制剂 Pending CN108602787A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562253039P 2015-11-09 2015-11-09
US62/253,039 2015-11-09
US201662338924P 2016-05-19 2016-05-19
US62/338,924 2016-05-19
PCT/US2016/061197 WO2017083433A1 (en) 2015-11-09 2016-11-09 Inhibitors of arginine gingipain

Publications (1)

Publication Number Publication Date
CN108602787A true CN108602787A (zh) 2018-09-28

Family

ID=58695180

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073083.4A Pending CN108602787A (zh) 2015-11-09 2016-11-09 精氨酸牙龈卟啉菌蛋白酶的抑制剂

Country Status (6)

Country Link
US (1) US10906881B2 (https=)
EP (1) EP3374352A4 (https=)
JP (1) JP6877424B2 (https=)
CN (1) CN108602787A (https=)
CA (1) CA3004095A1 (https=)
WO (1) WO2017083433A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112608976A (zh) * 2020-12-18 2021-04-06 珠海市德灏生物科技有限公司 一种牙周致病菌感染标记物检测试剂盒和检测方法
CN113825542A (zh) * 2019-03-21 2021-12-21 库特克希米公司 精氨酸牙龈蛋白酶抑制剂
CN116474096A (zh) * 2022-01-14 2023-07-25 中山大学附属口腔医院 靶向牙龈卟啉单胞菌RgpB在结直肠癌的治疗及预防中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CN110944637A (zh) 2017-05-10 2020-03-31 库特克希米公司 氨基吡啶化合物及其制备方法和使用方法
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors
CA3225141A1 (en) * 2021-07-13 2023-01-19 Keystone Bio, Inc. Diagnostics for porphyromonas gingivalis

Citations (1)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113825542A (zh) * 2019-03-21 2021-12-21 库特克希米公司 精氨酸牙龈蛋白酶抑制剂
CN112608976A (zh) * 2020-12-18 2021-04-06 珠海市德灏生物科技有限公司 一种牙周致病菌感染标记物检测试剂盒和检测方法
CN116474096A (zh) * 2022-01-14 2023-07-25 中山大学附属口腔医院 靶向牙龈卟啉单胞菌RgpB在结直肠癌的治疗及预防中的应用

Also Published As

Publication number Publication date
US20180334440A1 (en) 2018-11-22
JP2018534300A (ja) 2018-11-22
EP3374352A4 (en) 2019-10-02
EP3374352A1 (en) 2018-09-19
CA3004095A1 (en) 2017-05-18
WO2017083433A1 (en) 2017-05-18
US10906881B2 (en) 2021-02-02
JP6877424B2 (ja) 2021-05-26

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