JP6876156B2 - Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用 - Google Patents

Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用 Download PDF

Info

Publication number
JP6876156B2
JP6876156B2 JP2019570603A JP2019570603A JP6876156B2 JP 6876156 B2 JP6876156 B2 JP 6876156B2 JP 2019570603 A JP2019570603 A JP 2019570603A JP 2019570603 A JP2019570603 A JP 2019570603A JP 6876156 B2 JP6876156 B2 JP 6876156B2
Authority
JP
Japan
Prior art keywords
antibody
seq
il17a
represented
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019570603A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020511159A5 (https=
JP2020511159A (ja
Inventor
ツェン ドン
ツェン ドン
リ グゥオ
リ グゥオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Kanova Biopharmaceutical Co Ltd
Original Assignee
Suzhou Kanova Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Kanova Biopharmaceutical Co Ltd filed Critical Suzhou Kanova Biopharmaceutical Co Ltd
Publication of JP2020511159A publication Critical patent/JP2020511159A/ja
Publication of JP2020511159A5 publication Critical patent/JP2020511159A5/ja
Application granted granted Critical
Publication of JP6876156B2 publication Critical patent/JP6876156B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019570603A 2017-03-10 2017-03-10 Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用 Active JP6876156B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/076278 WO2018161340A1 (en) 2017-03-10 2017-03-10 Monoclonal antibody against both il-17a and il-17f and use of the same

Publications (3)

Publication Number Publication Date
JP2020511159A JP2020511159A (ja) 2020-04-16
JP2020511159A5 JP2020511159A5 (https=) 2020-05-28
JP6876156B2 true JP6876156B2 (ja) 2021-05-26

Family

ID=63448085

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019570603A Active JP6876156B2 (ja) 2017-03-10 2017-03-10 Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用

Country Status (7)

Country Link
US (1) US10858427B2 (https=)
EP (1) EP3592771A4 (https=)
JP (1) JP6876156B2 (https=)
KR (1) KR102321861B1 (https=)
CN (1) CN110582512B (https=)
AU (1) AU2017402210B2 (https=)
WO (1) WO2018161340A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110003329B (zh) * 2019-04-12 2022-09-27 深圳普瑞金生物药业股份有限公司 多肽、il17a/f单域抗体、核苷酸序列及试剂盒
US11827709B2 (en) * 2019-12-05 2023-11-28 Seagen Inc. Anti-AVB6 antibodies and antibody-drug conjugates
CN112915201B (zh) * 2019-12-06 2023-06-27 珠海市丽珠单抗生物技术有限公司 包含抗il-17抗体的液体制剂
CN119301153A (zh) * 2022-06-29 2025-01-10 上海齐鲁制药研究中心有限公司 结合il-17a和il-17f的抗体分子及其应用
CN116063493B (zh) * 2022-07-22 2023-09-01 贵州省赛尔生物科技有限公司 包含抗体和间充质干细胞外泌体的药物组合物及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
EP1963368B3 (en) * 2005-12-13 2020-06-10 Eli Lilly And Company Anti-il-17 antibodies
EP1996622A2 (en) * 2006-03-10 2008-12-03 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
JP5116842B2 (ja) 2007-04-27 2013-01-09 ザイモジェネティクス， インコーポレイテッド ＩＬ−１７ＡおよびＩｌ−１７Ｆの両方に結合する抗体ならびにそれを使用する方法
GB0807413D0 (en) * 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
RU2474588C2 (ru) * 2008-05-05 2013-02-10 Новиммун Са Перекрестно-реактивные антитела анти-il-17a/il-17f и способы их применения
MA33248B1 (fr) 2009-04-01 2012-05-02 Genentech Inc Traitement de troubles résistant à l'insuline
CN102458437B (zh) 2009-05-05 2015-06-10 诺维莫尼公司 抗il-17f抗体及其使用方法
ME02734B (me) * 2011-01-14 2017-10-20 Ucb Biopharma Sprl Antitelo koje vezuje il-17a i il-17f
US8945553B2 (en) 2012-05-22 2015-02-03 Bristol-Myers Squibb Company Bispecific antibodies to IL-23 and IL-17A/F
LT2953969T (lt) * 2013-02-08 2019-12-10 Novartis Ag Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui
WO2014161570A1 (en) * 2013-04-03 2014-10-09 Roche Glycart Ag Antibodies against human il17 and uses thereof
EP3027649B1 (en) * 2013-08-01 2020-04-01 F.Hoffmann-La Roche Ag Tnfa-il-17 bispecific antibodies
CN106336459B (zh) * 2015-07-13 2020-12-08 三生国健药业（上海）股份有限公司 抗人白细胞介素-17a单克隆抗体、其制备方法和应用

Also Published As

Publication number Publication date
AU2017402210A1 (en) 2019-10-31
KR20190128677A (ko) 2019-11-18
US10858427B2 (en) 2020-12-08
EP3592771A1 (en) 2020-01-15
AU2017402210B2 (en) 2021-08-19
CN110582512B (zh) 2022-08-30
US20200031919A1 (en) 2020-01-30
JP2020511159A (ja) 2020-04-16
WO2018161340A1 (en) 2018-09-13
CN110582512A (zh) 2019-12-17
KR102321861B1 (ko) 2021-11-05
EP3592771A4 (en) 2020-09-09

Similar Documents

Publication Publication Date Title
JP6883591B2 (ja) 抗ヒトインターロイキン−１７ａモノクローナル抗体、その製造方法及び使用
JP6876156B2 (ja) Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用
US20130064788A1 (en) Il-17 family cytokine compositions and uses
EP2322553A2 (en) Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
CN115433275B (zh) 抗胸腺基质淋巴细胞生成素（tslp）抗体及其用途
JP2002542769A (ja) Ｉｌ−１８により媒介される疾病の治療において有用な組み換えｉｌ−１８アンタゴニスト
JP2014530836A (ja) 炎症障害治療用のｉｌ１７ｃのアンタゴニスト
EP2970461A1 (en) Interferon alpha and omega antibody antagonists
KR102598319B1 (ko) 항-il-25 항체 및 그의 용도
JP7696291B2 (ja) 抗ｉｌ‐１７ａ抗体及びその適用
CN110483640A (zh) 白介素-6r的人源化单克隆抗体、其编码基因及应用
JP6930778B2 (ja) 抗ヒトインターロイキン１７ａモノクローナル抗体およびその使用
CN113698484B (zh) 抗il-23r抗体及其用途
CN116948031B (zh) 抗il-23r抗体及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20190926

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190906

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190906

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20190926

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200219

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200901

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201126

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210420

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210423

R150 Certificate of patent or registration of utility model

Ref document number: 6876156

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE

Ref document number: 6876156

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250