JP6861206B2 - マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法 - Google Patents

マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法 Download PDF

Info

Publication number
JP6861206B2
JP6861206B2 JP2018516678A JP2018516678A JP6861206B2 JP 6861206 B2 JP6861206 B2 JP 6861206B2 JP 2018516678 A JP2018516678 A JP 2018516678A JP 2018516678 A JP2018516678 A JP 2018516678A JP 6861206 B2 JP6861206 B2 JP 6861206B2
Authority
JP
Japan
Prior art keywords
rotor
sleeve
base
microcolumn
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018516678A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019501364A (ja
JP2019501364A5 (enExample
Inventor
ワン，レイ
ヂョウ，ヤオ
ワン，フゥ
リン，ミンシエン
ワン，トンジュン
バイ，リアン
フアン，グオリアン
ワン，ドン
シン，ワンリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CapitalBio Corp
Original Assignee
CapitalBio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CapitalBio Corp filed Critical CapitalBio Corp
Publication of JP2019501364A publication Critical patent/JP2019501364A/ja
Publication of JP2019501364A5 publication Critical patent/JP2019501364A5/ja
Application granted granted Critical
Publication of JP6861206B2 publication Critical patent/JP6861206B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0013—Rotary valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0011—Gate valves or sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/105—Mixing heads, i.e. compact mixing units or modules, using mixing valves for feeding and mixing at least two components
    • B01F25/1051—Mixing heads, i.e. compact mixing units or modules, using mixing valves for feeding and mixing at least two components of the mixing valve type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0025—Valves using microporous membranes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0063—Operating means specially adapted for microvalves using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sliding Valves (AREA)
JP2018516678A 2015-09-30 2016-09-30 マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法 Active JP6861206B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510640002.1 2015-09-30
CN201510640002.1A CN105135051B (zh) 2015-09-30 2015-09-30 一种微流控阀门和微流控芯片
PCT/CN2016/000549 WO2017054369A1 (en) 2015-09-30 2016-09-30 A microfluidic valve and a chip or system comprising the microfluidic valve

Publications (3)

Publication Number Publication Date
JP2019501364A JP2019501364A (ja) 2019-01-17
JP2019501364A5 JP2019501364A5 (enExample) 2019-09-19
JP6861206B2 true JP6861206B2 (ja) 2021-04-21

Family

ID=54720519

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018516678A Active JP6861206B2 (ja) 2015-09-30 2016-09-30 マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法

Country Status (5)

Country Link
US (1) US11268631B2 (enExample)
EP (1) EP3356712B1 (enExample)
JP (1) JP6861206B2 (enExample)
CN (1) CN105135051B (enExample)
WO (1) WO2017054369A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105135051B (zh) * 2015-09-30 2019-06-18 博奥生物集团有限公司 一种微流控阀门和微流控芯片
CN107398307B (zh) * 2016-05-18 2023-07-25 博奥生物集团有限公司 一种集成化微流控芯片
WO2018064775A1 (en) * 2016-10-07 2018-04-12 Xinyu Liu A microfluidic analytical platform for autonomous immunoassays
CN107096580A (zh) * 2017-06-09 2017-08-29 北京百康芯生物科技有限公司 一种具有旋转阀结构的微流控芯片
EP3763439A1 (en) 2019-07-12 2021-01-13 Curiosity Diagnostics sp. z o.o Microfluidic chip and valve, production process and uses
CN110215858A (zh) * 2019-07-15 2019-09-10 宁波镇海藤原电子科技有限公司 一种固液混合化学试剂配制机
WO2022243869A1 (en) * 2021-05-18 2022-11-24 Johnson & Johnson Consumer Inc. Biofluid sampling and monitoring for extended tracking and stress testing
CN113483122B (zh) * 2021-09-06 2021-11-26 江苏博赢环保科技有限公司 一种阀门以及具有该阀门的植物纤维包装餐具的反应釜
CN114225979B (zh) * 2021-12-06 2023-02-21 天津大学 微流控装置和微流控工作系统
CN115138409A (zh) * 2022-06-30 2022-10-04 中国科学院苏州生物医学工程技术研究所 适用于微流控系统集成的旋转阀
CN117903928B (zh) * 2024-03-19 2024-07-16 常州远望流体科技有限公司 多功能生物检测芯片
CN120984360A (zh) * 2025-10-23 2025-11-21 深圳市合川医疗股份有限公司 一种多通道微流控芯片主动阀

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2057904T3 (es) * 1990-06-15 1994-10-16 Chiron Corp Conjunto y aparato de ensayo, autonomos y completos en si mismos.
US8048386B2 (en) * 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US20020045243A1 (en) * 2000-09-15 2002-04-18 Laska Ronald C. Fluid cartridge and method
EP1258720B1 (en) * 2001-05-15 2007-07-18 Sysmex Corporation Measuring unit and rotary valve for use therein
US20030087198A1 (en) * 2001-09-19 2003-05-08 Dharmatilleke Saman Mangala Three-dimensional polymer nano/micro molding by sacrificial layer technique
US6568799B1 (en) * 2002-01-23 2003-05-27 Eastman Kodak Company Drop-on-demand ink jet printer with controlled fluid flow to effect drop ejection
US7582472B2 (en) * 2003-08-26 2009-09-01 Smith Kenneth E Apparatus and method for liquid sample testing
CN100417428C (zh) * 2003-09-30 2008-09-10 博奥生物有限公司 离心分离的仪器和方法
WO2006047777A2 (en) * 2004-10-27 2006-05-04 Cepheid Closed-system multi-stage nucleic acid amplification reactions
WO2008012550A2 (en) * 2006-07-28 2008-01-31 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
US7981386B2 (en) * 2008-06-20 2011-07-19 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic valve
US8716006B2 (en) 2009-04-03 2014-05-06 Integrated Nano-Technologies, Llc Multi-chamber rotating valve
US9347086B2 (en) * 2009-04-03 2016-05-24 Integrated Nano-Technologies, Llc Method and system for sample preparation
JP2011145185A (ja) 2010-01-15 2011-07-28 Sony Corp 流路構造、マイクロチップ及び送流方法
CN101907631B (zh) * 2010-07-19 2012-07-25 中国科学院长春光学精密机械与物理研究所 微流控芯片内的双液体毛细微流控制阀及其制作方法
SG11201406551WA (en) * 2012-07-12 2014-11-27 Agency Science Tech & Res A connector for microfluidic device, a method for injecting fluid into microfluidic device using the connector and a method of providing and operating a valve
CN102797872B (zh) * 2012-09-01 2014-01-15 安徽理工大学 一种基于超磁致伸缩薄膜驱动器的平面线圈驱动式微阀
PL401491A1 (pl) * 2012-11-07 2014-05-12 Scope Fluidics Spółka Z Ograniczoną Odpowiedzialnością Mikrokuwetka do oznaczeń biochemicznych
ITBO20120614A1 (it) 2012-11-08 2014-05-09 Gd Spa Macchina assemblatrice per la produzione di sigarette e relativo metodo di assemblaggio.
DE102013203656B4 (de) * 2013-03-04 2016-03-03 Robert Bosch Gmbh Mikrofluidisches Drehventil
WO2015084458A2 (en) * 2013-09-18 2015-06-11 California Institute Of Technology System and method for movement and timing control
CN205047979U (zh) * 2015-09-30 2016-02-24 博奥生物集团有限公司 一种微流控阀门和微流控芯片
CN105135051B (zh) 2015-09-30 2019-06-18 博奥生物集团有限公司 一种微流控阀门和微流控芯片

Also Published As

Publication number Publication date
JP2019501364A (ja) 2019-01-17
US11268631B2 (en) 2022-03-08
EP3356712A4 (en) 2019-03-20
EP3356712A1 (en) 2018-08-08
CN105135051A (zh) 2015-12-09
CN105135051B (zh) 2019-06-18
WO2017054369A1 (en) 2017-04-06
EP3356712B1 (en) 2021-09-01
US20180266586A1 (en) 2018-09-20

Similar Documents

Publication Publication Date Title
JP6861206B2 (ja) マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法
Gorkin et al. Centrifugal microfluidics for biomedical applications
JP3947536B2 (ja) 液体中の検体測定方法および装置
US8317990B2 (en) Droplet actuator loading and target concentration
CN112756017B (zh) 微流控芯片及体外检测装置
US8771609B2 (en) Module for processing a biological sample, biochip kit, and use of the module
EP2165764B1 (en) Microfluidic device
US20020151078A1 (en) Microfluidics devices and methods for high throughput screening
CN106489072B (zh) 具有计量室的用于分析生物样品的旋转筒
US20040203136A1 (en) Microfluidics devices and methods of diluting samples and reagents
US20150047978A1 (en) Biosensor having nanostructured electrodes
CN105026932A (zh) 微流控分配设备
WO2020107641A1 (zh) 一种设置有微流控或纳米流控结构的生物反应装置
EP3749451B1 (en) Microfluidic probe head with aspiration posts
US20060263265A1 (en) Blood micro-separator
Yan et al. Chemical cytometry on microfluidic chips
TWI390041B (zh) Biological wafer
JP5137014B2 (ja) マイクロチップ
CN216155821U (zh) 核酸提取装置
CN117181326A (zh) 一种流道结构、离心微流控芯片及其使用方法
CN211586658U (zh) 一种微流体芯片
CN116099578A (zh) 微流控检测芯片
Jin et al. Nanoliter-scale liquid metering and droplet generation based on a capillary array for high throughput screening
Klemm et al. Magnetic particle-based sample-prep and valveing in microfluidic devices
CN211385058U (zh) 一种混沌对流混匀装置

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190806

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190806

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200729

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210210

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210302

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210329

R150 Certificate of patent or registration of utility model

Ref document number: 6861206

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250