CN105135051B - 一种微流控阀门和微流控芯片 - Google Patents

一种微流控阀门和微流控芯片 Download PDF

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Publication number
CN105135051B
CN105135051B CN201510640002.1A CN201510640002A CN105135051B CN 105135051 B CN105135051 B CN 105135051B CN 201510640002 A CN201510640002 A CN 201510640002A CN 105135051 B CN105135051 B CN 105135051B
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micro
rotor
sleeve
base
column
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CN201510640002.1A
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English (en)
Chinese (zh)
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CN105135051A (zh
Inventor
王磊
周峣
王虎
林明仙
王彤珺
白亮
黄国亮
王东
邢婉丽
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Tsinghua University
CapitalBio Corp
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CapitalBio Corp
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Priority to CN201510640002.1A priority Critical patent/CN105135051B/zh
Publication of CN105135051A publication Critical patent/CN105135051A/zh
Priority to US15/757,321 priority patent/US11268631B2/en
Priority to JP2018516678A priority patent/JP6861206B2/ja
Priority to PCT/CN2016/000549 priority patent/WO2017054369A1/en
Priority to EP16850004.9A priority patent/EP3356712B1/en
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0011—Gate valves or sliding valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0013—Rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/105—Mixing heads, i.e. compact mixing units or modules, using mixing valves for feeding and mixing at least two components
    • B01F25/1051—Mixing heads, i.e. compact mixing units or modules, using mixing valves for feeding and mixing at least two components of the mixing valve type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0025—Valves using microporous membranes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0063—Operating means specially adapted for microvalves using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sliding Valves (AREA)
CN201510640002.1A 2015-09-30 2015-09-30 一种微流控阀门和微流控芯片 Active CN105135051B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201510640002.1A CN105135051B (zh) 2015-09-30 2015-09-30 一种微流控阀门和微流控芯片
US15/757,321 US11268631B2 (en) 2015-09-30 2016-09-30 Microfluidic valve and a chip or system comprising the microfluidic valve
JP2018516678A JP6861206B2 (ja) 2015-09-30 2016-09-30 マイクロ流体バルブおよびマイクロ流体バルブを備えたチップ、ならびにマイクロ流体バルブの使用方法
PCT/CN2016/000549 WO2017054369A1 (en) 2015-09-30 2016-09-30 A microfluidic valve and a chip or system comprising the microfluidic valve
EP16850004.9A EP3356712B1 (en) 2015-09-30 2016-09-30 A microfluidic valve and a chip comprising the microfluidic valve

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510640002.1A CN105135051B (zh) 2015-09-30 2015-09-30 一种微流控阀门和微流控芯片

Publications (2)

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CN105135051A CN105135051A (zh) 2015-12-09
CN105135051B true CN105135051B (zh) 2019-06-18

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Country Status (5)

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US (1) US11268631B2 (enExample)
EP (1) EP3356712B1 (enExample)
JP (1) JP6861206B2 (enExample)
CN (1) CN105135051B (enExample)
WO (1) WO2017054369A1 (enExample)

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CN105135051B (zh) * 2015-09-30 2019-06-18 博奥生物集团有限公司 一种微流控阀门和微流控芯片
CN107398307B (zh) * 2016-05-18 2023-07-25 博奥生物集团有限公司 一种集成化微流控芯片
WO2018064775A1 (en) * 2016-10-07 2018-04-12 Xinyu Liu A microfluidic analytical platform for autonomous immunoassays
CN107096580A (zh) * 2017-06-09 2017-08-29 北京百康芯生物科技有限公司 一种具有旋转阀结构的微流控芯片
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CN110215858A (zh) * 2019-07-15 2019-09-10 宁波镇海藤原电子科技有限公司 一种固液混合化学试剂配制机
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CN113483122B (zh) * 2021-09-06 2021-11-26 江苏博赢环保科技有限公司 一种阀门以及具有该阀门的植物纤维包装餐具的反应釜
CN114225979B (zh) * 2021-12-06 2023-02-21 天津大学 微流控装置和微流控工作系统
CN115138409A (zh) * 2022-06-30 2022-10-04 中国科学院苏州生物医学工程技术研究所 适用于微流控系统集成的旋转阀
CN117903928B (zh) * 2024-03-19 2024-07-16 常州远望流体科技有限公司 多功能生物检测芯片
CN120984360A (zh) * 2025-10-23 2025-11-21 深圳市合川医疗股份有限公司 一种多通道微流控芯片主动阀

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Also Published As

Publication number Publication date
JP2019501364A (ja) 2019-01-17
US11268631B2 (en) 2022-03-08
EP3356712A4 (en) 2019-03-20
JP6861206B2 (ja) 2021-04-21
EP3356712A1 (en) 2018-08-08
CN105135051A (zh) 2015-12-09
WO2017054369A1 (en) 2017-04-06
EP3356712B1 (en) 2021-09-01
US20180266586A1 (en) 2018-09-20

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