JP3947536B2 - 液体中の検体測定方法および装置 - Google Patents
液体中の検体測定方法および装置 Download PDFInfo
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- JP3947536B2 JP3947536B2 JP2004249094A JP2004249094A JP3947536B2 JP 3947536 B2 JP3947536 B2 JP 3947536B2 JP 2004249094 A JP2004249094 A JP 2004249094A JP 2004249094 A JP2004249094 A JP 2004249094A JP 3947536 B2 JP3947536 B2 JP 3947536B2
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
Description
2 カバー
3 カバーの弾性領域
4 廃棄物容器
5 吸引フリース
6 廃棄物滴
7 変換器要素
8 磁石
9 加熱要素
10 換気装置
11 セプタム
12 変換器要素の電気接触子
13 留め具
14 イオン選択電極
15 参照電極
16 オリフィス
17 イオン選択電極の電気接触子
18 好ましい移動経路
19 検査する液体試料
20 参照電解質溶液
21 検査部位
22 試薬容器
23 参照電極の電気接触子
24 投与装置
25 ノズル
26 スピンドル
27 励起光
28 蛍光
29 ステップ・モータ
30 粘度を測定するためのセンサ電極
Claims (8)
- 液体中の検体を測定する方法において
a)検査する液体量が、運搬平面の基板に適用され、
b)検査する液体量が、運搬平面の基板上で検査部位に移動され、
c)検査部位で、検査する液体量がさらに、運搬平面の基板と反対側の検出平面内に配置されたセンサ要素に接触され、
d)検査する液体量中の検体が、センサ要素によって測定される方法であって、
ステップb)において、液体量が運搬平面の基板のみと接触することを特徴とする方法。 - 液体量が、音響表面波またはエレクトロウェッティングに基づく方法により移動されることを特徴とする、請求項1に記載の方法。
- 検査部位での運搬平面からのセンサ要素または検出平面の距離を永久的に変えることにより、センサ要素が検査する液体量と接触することを特徴とする、請求項1または2に記載の方法。
- 検体を測定するため、運搬平面からのセンサ要素または検出平面の距離を一時的に変えることにより、センサ要素が検査する液体量と接触することを特徴とする、請求項1または2に記載の方法。
- 試料適用部位から検査部位へ検査する液体量がその上で移動される運搬平面の基板と、運搬平面と反対側にある検出平面内に配置された、検体を測定する少なくとも1つのセンサ要素とを備える、液体中の検体を測定する装置であって、
少なくとも検査部位において、検出平面と運搬平面の間の距離が永久的に減少していて、センサ領域の外側では該距離が液体量の縦寸法より大きく、センサ領域の内側では、すなわち検査部においては該距離が液体量の縦寸法より小さいか等しくなっており、液体量が、検査部位に移動する間に運搬平面の基板のみと接触し、検体を測定するためにセンサ要素のみとさらに接触し、運搬平面は平らな基板の形をしていることを特徴とする装置。 - 試料適用部位から検査部位へ検査する液体量がその上で移動される運搬平面の基板と、運搬平面と反対側にある検出平面内に配置された、検体を測定する少なくとも1つのセンサ要素とを備える、液体中の検体を測定する装置であって、
センサ要素または検出平面と運搬平面の間の距離が少なくとも検査部位において減少可能になっていて、液体量が、検査部位に移動する間に運搬平面の基板のみと接触し、検体を測定するためにセンサ要素のみとさらに接触するように設計されており、運搬平面は平らな基板の形をしていることを特徴とする装置。 - 検体を測定するため、特に検査部位で、運搬平面からのセンサ要素または検出平面の距離を一時的に変えることにより、好ましくはセンサ要素を一時的に運搬平面の基板に近づけることにより、センサ要素が検査する液体量と接触することを特徴とする、請求項6に記載の装置。
- 分子生物学的増幅方法により検体を検出することを目的として、追加の温度制御領域が検出平面に一体化されており、且つ、これらの温度制御領域が、反応混合物の温度を調節することを目的として、a)温度制御領域内で運搬平面からの検出平面の距離を永久的に変えることにより、またはb)運搬平面からの温度制御領域または検出平面全体からの距離を一時的に変えることにより、温度制御領域が反応混合物と接触するように設計されていることを特徴とする、請求項5〜7のいずれか一項に記載の装置。
Applications Claiming Priority (1)
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EP03019811 | 2003-08-30 |
Publications (2)
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JP2005130851A JP2005130851A (ja) | 2005-05-26 |
JP3947536B2 true JP3947536B2 (ja) | 2007-07-25 |
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US (1) | US8268245B2 (ja) |
JP (1) | JP3947536B2 (ja) |
CA (1) | CA2479452C (ja) |
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US20020187564A1 (en) * | 2001-06-08 | 2002-12-12 | Caliper Technologies Corp. | Microfluidic library analysis |
AU2004238846B2 (en) | 2003-05-09 | 2007-10-25 | Caliper Life Sciences, Inc. | Automated sample analysis |
CA2479452C (en) | 2003-08-30 | 2008-11-04 | F.Hoffmann-La Roche Ag | Method and device for determining analytes in a liquid |
US8257966B2 (en) | 2006-02-20 | 2012-09-04 | Shimadzu Corporation | Reaction kit |
JP4591377B2 (ja) | 2006-02-20 | 2010-12-01 | 株式会社島津製作所 | 反応キット |
JP4591401B2 (ja) | 2006-04-17 | 2010-12-01 | 株式会社島津製作所 | 反応容器 |
JP4591407B2 (ja) | 2006-06-01 | 2010-12-01 | 株式会社島津製作所 | 反応キット |
JP4591408B2 (ja) | 2006-06-01 | 2010-12-01 | 株式会社島津製作所 | 反応キット |
JP4548359B2 (ja) | 2006-02-20 | 2010-09-22 | 株式会社島津製作所 | 反応キット処理装置 |
JP4591409B2 (ja) | 2006-06-01 | 2010-12-01 | 株式会社島津製作所 | 分注チップ及びそれを用いた反応キット |
US8333937B2 (en) | 2006-06-01 | 2012-12-18 | Shimadzu Corporation | Dispensation tip, reaction kit using the same, and dispensation tip drive mechanism |
-
2004
- 2004-08-25 CA CA002479452A patent/CA2479452C/en not_active Expired - Fee Related
- 2004-08-26 US US10/926,926 patent/US8268245B2/en not_active Expired - Fee Related
- 2004-08-27 JP JP2004249094A patent/JP3947536B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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US8268245B2 (en) | 2012-09-18 |
JP2005130851A (ja) | 2005-05-26 |
US20050106742A1 (en) | 2005-05-19 |
CA2479452A1 (en) | 2005-02-28 |
CA2479452C (en) | 2008-11-04 |
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