JP6858181B2 - 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ - Google Patents

免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ Download PDF

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JP6858181B2
JP6858181B2 JP2018516740A JP2018516740A JP6858181B2 JP 6858181 B2 JP6858181 B2 JP 6858181B2 JP 2018516740 A JP2018516740 A JP 2018516740A JP 2018516740 A JP2018516740 A JP 2018516740A JP 6858181 B2 JP6858181 B2 JP 6858181B2
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cancer
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イェルク・ヴィッシュフーゼン
マルクス・ハーケ
ラインハルト・ドゥマー
マティアス・メーリング
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ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5751—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
    • G—PHYSICS
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    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Oncology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018516740A 2015-10-02 2016-09-30 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５ Active JP6858181B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1517527.6A GB201517527D0 (en) 2015-10-02 2015-10-02 GDF-15 as a diagnosis marker to predict the clinical outcome of a treatment with immune checkpoint blockers
GB1517527.6 2015-10-02
GBGB1607800.8A GB201607800D0 (en) 2016-04-29 2016-04-29 GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers
GB1607800.8 2016-04-29
PCT/EP2016/073519 WO2017055612A1 (en) 2015-10-02 2016-09-30 Gdf-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers

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JP2018535404A JP2018535404A (ja) 2018-11-29
JP2018535404A5 JP2018535404A5 (enExample) 2021-01-21
JP6858181B2 true JP6858181B2 (ja) 2021-04-14

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KR (1) KR102621034B1 (enExample)
AU (1) AU2016333538B2 (enExample)
CA (1) CA3000290C (enExample)
DK (1) DK3356827T3 (enExample)
ES (1) ES2968226T3 (enExample)
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EP3356827B1 (en) 2023-12-06
DK3356827T3 (da) 2024-01-08
AU2016333538A1 (en) 2018-04-26
CA3000290C (en) 2023-02-21
KR102621034B1 (ko) 2024-01-03
JP2018535404A (ja) 2018-11-29
ES2968226T3 (es) 2024-05-08
US20260140123A1 (en) 2026-05-21
AU2016333538B2 (en) 2022-03-31
KR20180054867A (ko) 2018-05-24
EP3356827A1 (en) 2018-08-08
EP4321866A3 (en) 2024-03-20
CA3000290A1 (en) 2017-04-06
FI3356827T3 (fi) 2024-01-03
US20180292412A1 (en) 2018-10-11
US12473354B2 (en) 2025-11-18
US11262360B2 (en) 2022-03-01
US20220242942A1 (en) 2022-08-04
EP4321866A2 (en) 2024-02-14

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