JP6849686B2 - 重水素化されたｃｆｔｒ増強剤の投与 - Google Patents
重水素化されたｃｆｔｒ増強剤の投与 Download PDFInfo
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- JP6849686B2 JP6849686B2 JP2018534496A JP2018534496A JP6849686B2 JP 6849686 B2 JP6849686 B2 JP 6849686B2 JP 2018534496 A JP2018534496 A JP 2018534496A JP 2018534496 A JP2018534496 A JP 2018534496A JP 6849686 B2 JP6849686 B2 JP 6849686B2
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| JP7214743B2 (ja) | 2018-02-15 | 2023-01-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとしての大環状分子、それらの医薬組成物、嚢胞性線維症の治療におけるそれらの使用、及びそれらの製造方法 |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| FI3880197T3 (fi) | 2018-11-14 | 2023-05-04 | Vertex Pharma | Menetelmiä kystisen fibroosin hoitamiseksi |
| UY38630A (es) | 2019-04-03 | 2020-10-30 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
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| FR3096890B1 (fr) | 2019-06-07 | 2021-05-14 | H4 Orphan Pharma | Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique. |
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| SMT201800074T1 (it) | 2008-08-13 | 2018-05-02 | Vertex Pharma | Composizione farmaceutica di n-[2,4-bis(1,1-dimetiletil)-5-idrossifenil]-1,4-diidro-4-ossochinolin-3-carbossammide e sua somministrazione |
| EP2575814A1 (en) | 2010-05-20 | 2013-04-10 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| PT2709986T (pt) * | 2011-05-18 | 2017-06-26 | Concert Pharmaceuticals Inc | Derivados deuterados de ivacaftor |
| BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
| MY178621A (en) * | 2012-11-19 | 2020-10-19 | Vertex Pharmaceuticals Europe Ltd | Deuterated cftr potentiators |
| CN109364075B (zh) * | 2012-11-21 | 2021-10-29 | 顶点制药（欧洲）有限公司 | 氘化cftr增效剂 |
| US20140221424A1 (en) * | 2013-01-30 | 2014-08-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for use in the treatment of cystic fibrosis |
| MX388470B (es) | 2015-09-21 | 2025-03-20 | Vertex Pharmaceuticals Europe Ltd | Administración de potenciadores de regulador de la conductancia transmembrana de fibrosis quística (cftr) deuterados. |
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