JP6846362B2 - 線維性疾患を処置するための方法および組成物 - Google Patents

線維性疾患を処置するための方法および組成物 Download PDF

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JP6846362B2
JP6846362B2 JP2017565185A JP2017565185A JP6846362B2 JP 6846362 B2 JP6846362 B2 JP 6846362B2 JP 2017565185 A JP2017565185 A JP 2017565185A JP 2017565185 A JP2017565185 A JP 2017565185A JP 6846362 B2 JP6846362 B2 JP 6846362B2
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antibody
amino acid
fibrosis
seq
acid sequence
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JP2018525332A5 (OSRAM
JP2018525332A (ja
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クリストファー ロバート ベビントン，
クリストファー ロバート ベビントン，
ネナド トマセヴィック，
ネナド トマセヴィック，
ルストム ファラハティ，
ルストム ファラハティ，
ブラッドフォード アンドリュー ヤングブラッド，
ブラッドフォード アンドリュー ヤングブラッド，
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アラコス インコーポレイテッド
アラコス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017565185A 2015-06-17 2016-06-16 線維性疾患を処置するための方法および組成物 Active JP6846362B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562181146P 2015-06-17 2015-06-17
US62/181,146 2015-06-17
US201662296482P 2016-02-17 2016-02-17
US62/296,482 2016-02-17
US201662344357P 2016-06-01 2016-06-01
US62/344,357 2016-06-01
PCT/US2016/037935 WO2016205567A1 (en) 2015-06-17 2016-06-16 Methods and compositions for treating fibrotic diseases

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JP2018525332A JP2018525332A (ja) 2018-09-06
JP2018525332A5 JP2018525332A5 (OSRAM) 2019-07-18
JP6846362B2 true JP6846362B2 (ja) 2021-03-24

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US (3) US10774145B2 (OSRAM)
EP (1) EP3310385A4 (OSRAM)
JP (2) JP6846362B2 (OSRAM)
AU (1) AU2016278239B9 (OSRAM)
CA (1) CA2987797A1 (OSRAM)
HK (1) HK1254432A1 (OSRAM)
WO (1) WO2016205567A1 (OSRAM)

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US10604577B2 (en) 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
WO2018129400A1 (en) * 2017-01-06 2018-07-12 Allakos Inc. Methods and compositions for treating chronic obstructive pulmonary disorder
EP3618872A4 (en) * 2017-05-05 2021-06-30 Allakos Inc. METHODS AND COMPOSITIONS FOR TREATMENT OF INFLAMMATORY STOMACH AND INTESTINAL DISEASES
EA201992626A1 (ru) * 2017-05-05 2020-04-24 Аллакос Инк. Способы и композиции для лечения аллергических заболеваний глаз
CA3128505A1 (en) * 2019-02-06 2020-08-13 Oncoimmune, Inc. Targeting cd24-siglec interactions for the treatment and prevention of nonalcoholic steatohepatitis
WO2022061032A1 (en) * 2020-09-17 2022-03-24 Allakos Inc. Methods and compositions for treating viral infection
WO2022204045A1 (en) * 2021-03-22 2022-09-29 Spiritus Therapeutics, Inc. Diagnostic and therapeutic uses of purified potent exosomes containing disease-based and therapy based signature cargo
US11631208B1 (en) * 2021-12-22 2023-04-18 RealizeMD Ltd. Systems and methods for generating clinically relevant images that preserve physical attributes of humans while protecting personal identity
US11935238B2 (en) * 2021-12-22 2024-03-19 RealizeMD Ltd. Systems and methods for generating clinically relevant images that preserve physical attributes of humans while protecting personal identity

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WO2016205567A1 (en) 2016-12-22
EP3310385A4 (en) 2018-12-19
US20180179279A1 (en) 2018-06-28
HK1254432A1 (zh) 2019-07-19
JP2018525332A (ja) 2018-09-06
JP2021080289A (ja) 2021-05-27
AU2016278239A1 (en) 2018-01-04
US10774145B2 (en) 2020-09-15
AU2016278239B2 (en) 2022-07-21
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