JP6819012B2 - 癌と転移を処置するための低密度焦点式超音波 - Google Patents

癌と転移を処置するための低密度焦点式超音波 Download PDF

Info

Publication number
JP6819012B2
JP6819012B2 JP2017563052A JP2017563052A JP6819012B2 JP 6819012 B2 JP6819012 B2 JP 6819012B2 JP 2017563052 A JP2017563052 A JP 2017563052A JP 2017563052 A JP2017563052 A JP 2017563052A JP 6819012 B2 JP6819012 B2 JP 6819012B2
Authority
JP
Japan
Prior art keywords
tumor
ultrasonic
lofu
cells
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017563052A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018517495A5 (https=
JP2018517495A (ja
Inventor
グハ，チャンダン
バリー，ステファン
マシアン，フェルナンド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Montefiore Medical Center
Original Assignee
Montefiore Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Montefiore Medical Center filed Critical Montefiore Medical Center
Publication of JP2018517495A publication Critical patent/JP2018517495A/ja
Publication of JP2018517495A5 publication Critical patent/JP2018517495A5/ja
Application granted granted Critical
Publication of JP6819012B2 publication Critical patent/JP6819012B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N2005/002—Cooling systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0091—Beam steering with moving parts, e.g. transducers, lenses, reflectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Human Computer Interaction (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2017563052A 2015-06-03 2016-06-02 癌と転移を処置するための低密度焦点式超音波 Active JP6819012B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562170378P 2015-06-03 2015-06-03
US62/170,378 2015-06-03
US201562204312P 2015-08-12 2015-08-12
US62/204,312 2015-08-12
PCT/US2016/035440 WO2016196741A2 (en) 2015-06-03 2016-06-02 Low intensity focused ultrasound for treating cancer and metastasis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020206143A Division JP7105294B2 (ja) 2015-06-03 2020-12-11 癌と転移を処置するための低密度焦点式超音波

Publications (3)

Publication Number Publication Date
JP2018517495A JP2018517495A (ja) 2018-07-05
JP2018517495A5 JP2018517495A5 (https=) 2019-07-04
JP6819012B2 true JP6819012B2 (ja) 2021-01-27

Family

ID=57442265

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017563052A Active JP6819012B2 (ja) 2015-06-03 2016-06-02 癌と転移を処置するための低密度焦点式超音波
JP2020206143A Active JP7105294B2 (ja) 2015-06-03 2020-12-11 癌と転移を処置するための低密度焦点式超音波
JP2022111273A Active JP7635177B2 (ja) 2015-06-03 2022-07-11 癌と転移を処置するための低密度焦点式超音波

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020206143A Active JP7105294B2 (ja) 2015-06-03 2020-12-11 癌と転移を処置するための低密度焦点式超音波
JP2022111273A Active JP7635177B2 (ja) 2015-06-03 2022-07-11 癌と転移を処置するための低密度焦点式超音波

Country Status (5)

Country Link
US (3) US10974077B2 (https=)
EP (1) EP3302264B1 (https=)
JP (3) JP6819012B2 (https=)
CN (2) CN114886412B (https=)
WO (1) WO2016196741A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021058618A (ja) * 2015-06-03 2021-04-15 モンテフィオーレ メディカル センターＭｏｎｔｅｆｉｏｒｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌と転移を処置するための低密度焦点式超音波
US11179581B2 (en) 2015-03-09 2021-11-23 The Research Foundation For The State University Of New York Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration
US12434076B2 (en) 2017-11-09 2025-10-07 Montefiore Medical Center Low energy immune priming for treating cancer and metastasis

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3525883A4 (en) 2016-10-16 2020-12-02 Vibrato Medical, Inc. EXTRACORPORAL THERAPEUTIC ULTRASOUND TO PROMOTE ANGIOGENESIS
ES2989606T3 (es) * 2017-12-22 2024-11-27 Freedom Waves S R L Sistema para inducir la sonoporación de un fármaco en células cancerosas
US11260249B2 (en) * 2018-07-19 2022-03-01 Sonablate Corp. System, apparatus and method for high intensity focused ultrasound and tissue healing activation
JP2020110282A (ja) * 2019-01-10 2020-07-27 治 三宅 生体用の超音波照射治療装置
IL285384B2 (en) 2019-02-13 2024-11-01 Alpheus Medical Inc Non-invasive sonodynamic therapy
WO2020165383A1 (fr) * 2019-02-15 2020-08-20 Boysset Max Pièce d'habillement et méthode de contrôle de cellules utilisant une telle pièce d'habillement
CN110507917A (zh) * 2019-07-30 2019-11-29 哈尔滨医科大学 一种超高场磁共振引导的低强度聚焦超声爆破系统
EP4021568A4 (en) * 2019-08-27 2023-11-01 Montefiore Medical Center Post-ablative modulation of radiation therapy
US20210169979A1 (en) * 2019-12-05 2021-06-10 The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges System and method for sonosensitized cancer immunotherapy with nanoparticles
WO2022032043A1 (en) * 2020-08-06 2022-02-10 Montefiore Medical Center Dendritic cell activating therapy as an adjunct to radiation therapy
WO2022032283A2 (en) 2020-08-07 2022-02-10 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
JP2024511277A (ja) 2021-02-19 2024-03-13 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのガントリー
US12364880B2 (en) * 2021-03-15 2025-07-22 Guided Therapy Systems, Llc Method for mid-intensity, non-ablative acoustic treatment of injured tissue
WO2023060199A1 (en) * 2021-10-06 2023-04-13 The Trustees Of Columbia University In The City Of New York Method and integrated system for selective removal of defective cells and edematous fluids from the lung
WO2023105290A1 (en) * 2021-12-10 2023-06-15 Insightec, Ltd. Short-pulse sonodynamic treatment apparatus
US20230293913A1 (en) * 2022-03-17 2023-09-21 Open Water Internet Inc. Harmonic excitation therapy and anti-tumor agent
EP4577138A1 (en) * 2022-08-22 2025-07-02 LaserLeap Technologies, S.A. Devices and methods for priming solid tumors with pressure pulses to enhance anticancer therapies
EP4719591A1 (en) * 2023-06-01 2026-04-08 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University Therapeutic ultrasound methods

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068961A3 (fr) 1981-06-26 1983-02-02 Thomson-Csf Dispositif d'échauffement localisé de tissus biologiques
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
WO2001032258A2 (en) 1999-11-01 2001-05-10 University Of Cincinnati Transcranial ultrasound thrombolysis system and method of treating a stroke
US6725095B2 (en) 2000-04-13 2004-04-20 Celsion Corporation Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue
US6821274B2 (en) * 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
US20100087728A1 (en) 2000-11-28 2010-04-08 Physiosonics, Inc. Acoustic palpation using non-invasive ultrasound techniques to identify and localize tissue eliciting biological responses
US20040034304A1 (en) 2001-12-21 2004-02-19 Chikayoshi Sumi Displacement measurement method and apparatus, strain measurement method and apparatus elasticity and visco-elasticity constants measurement apparatus, and the elasticity and visco-elasticity constants measurement apparatus-based treatment apparatus
DE60324417D1 (de) 2002-05-23 2008-12-11 Gendel Ltd Ablationsvorrichtung
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
US7896821B1 (en) * 2003-11-14 2011-03-01 Perfusion Technology, LLC Low intensity directed ultrasound (LODUS) mediated blood brain barrier disruption
KR20060113930A (ko) 2003-12-30 2006-11-03 리포소닉스 인코포레이티드 지방 조직의 파괴를 위한 시스템 및 장치
BRPI0507691A (pt) 2004-02-12 2007-07-24 Neurosonix Ltd controle acústico de êmbolos in vivo
KR100537343B1 (ko) * 2004-10-01 2005-12-19 주식회사 듀플로젠 관절염 치료용 초음파 장치
US20080260650A1 (en) 2004-10-28 2008-10-23 The General Hospital Corporation Methods of Detection and Therapy of Inflamed Tissues Using Immune Modulation
CN1814323B (zh) * 2005-01-31 2010-05-12 重庆海扶(Hifu)技术有限公司 一种聚焦超声波治疗系统
US7194063B2 (en) 2005-02-10 2007-03-20 Brookhaven Science Associates, Llc Methods for implementing microbeam radiation therapy
WO2006113794A2 (en) 2005-04-20 2006-10-26 Richard Blankenbecler Treatment to reduce damage from radiation therapy
CN101291705A (zh) * 2005-06-07 2008-10-22 皇家飞利浦电子股份有限公司 使用相可变流体的超声药物传输和热治疗的方法和装置
JP4369907B2 (ja) 2005-07-01 2009-11-25 株式会社日立製作所 音響化学治療装置
WO2007014105A2 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated Method and system for adapting a radiation therapy treatment plan based on a biological model
WO2007044469A2 (en) * 2005-10-05 2007-04-19 Perfusion Technology, Llp A method and apparatus to direct radiation treatment to a specific region of the brain
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
WO2010029556A1 (en) * 2008-09-12 2010-03-18 Slender Medical, Ltd. A device for ultrasound treatment and monitoring tissue treatment
JP5032094B2 (ja) * 2006-11-06 2012-09-26 テルモ株式会社 超音波診断装置および制御プログラム
WO2008115830A2 (en) 2007-03-16 2008-09-25 Cyberheart, Inc. Radiation treatment planning and delivery for moving targets in the heart
EP2131925A2 (en) 2007-03-30 2009-12-16 Koninklijke Philips Electronics N.V. Mri-guided hifu marking to guide radiotherapy and other procedures
CA2706563C (en) 2007-11-21 2018-08-21 Focus Surgery, Inc. Method of diagnosis and treatment of tumors using high intensity focused ultrasound
WO2009070677A1 (en) 2007-11-28 2009-06-04 Reliant Technologies, Inc. Nonablative and ablative tissue treatment method and device
US8466605B2 (en) * 2008-03-13 2013-06-18 Ultrashape Ltd. Patterned ultrasonic transducers
US20100286673A1 (en) 2008-03-17 2010-11-11 Palomar Medical Technologies, Inc. Method and apparatus for treatment of tissue
CN105126262B (zh) * 2008-07-14 2019-03-22 代理并代表亚利桑那州立大学的亚利桑那董事会 使用超声用于调节细胞活性的方法和装置
US8962290B2 (en) 2008-08-26 2015-02-24 Intelligentnano Inc. Enhanced animal cell growth using ultrasound
CN101642607B (zh) * 2009-09-01 2012-11-28 西安交通大学 基于阵列换能器的低强度聚焦超声药物控释与监控装置
CN101690677B (zh) * 2009-10-13 2011-09-21 西安交通大学 聚焦超声治疗组合阵元相控阵及多焦点剪切波成像系统
US20130144192A1 (en) * 2011-07-17 2013-06-06 Neurotrek, Inc. Ultrasound neuromodulation treatment of anxiety (including panic attacks) and obsessive-compulsive disorder
GB2479598B (en) * 2010-04-16 2012-11-21 Cancercure Technology As Methods and systems for inducing hyperthermia
JP5775929B2 (ja) * 2010-05-27 2015-09-09 コーニンクレッカ フィリップス エヌ ヴェ 超音波及び熱を選択的に生成する超音波トランスデューサ
US8777854B2 (en) * 2011-09-06 2014-07-15 General Electric Company Method and system for ultrasound based automated detection, quantification and tracking of pathologies
US20140058293A1 (en) * 2012-05-23 2014-02-27 Sunnybrook Research Institute Multi-Frequency Ultrasound Device and Method of Operation
SG11201408652SA (en) 2012-06-26 2015-01-29 Biodesix Inc Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
EP2869815A4 (en) * 2012-07-08 2016-03-16 Sunnybrook Health Sciences Ct A SYSTEM AND METHOD FOR THE USE OF ULTRASOUND STIMULATED MICROBUBBLE EXPOSURES FOR THE INDUCTION OF CERAMIDA CUMULATION IN ENDOTHELIC AND TUMOR CELLS
JP2015524699A (ja) * 2012-07-30 2015-08-27 ノースン・カンパニー・リミテッドNohsn Co., Ltd. 勾配情報を有する超音波プローブ、それを用いた超音波診断及び治療装置
CN102831716A (zh) * 2012-08-27 2012-12-19 曲宝源 预付费球形膨胀腔低压损立柱式超声波热量表
US9061133B2 (en) * 2012-12-27 2015-06-23 Brainsonix Corporation Focused ultrasonic transducer navigation system
AU2014207272A1 (en) * 2013-01-18 2015-07-30 Neal D. Andruska Estrogen receptor inhibitors
CN203112640U (zh) * 2013-02-05 2013-08-07 韩先锋 旋流分区式船舶压载水处理装置
US10960233B2 (en) 2013-03-06 2021-03-30 B.G. Negev Technologies And Applications Ltd. Low intensity ultrasound therapy
WO2014145007A1 (en) 2013-03-15 2014-09-18 Eagleyemed Ultrasound probe
CN103230648B (zh) * 2013-04-24 2016-09-14 重庆医科大学 低强度聚焦超声分子显像与治疗系统
WO2015067786A1 (en) 2013-11-08 2015-05-14 Koninklijke Philips N.V. Medical apparatus for radiotherapy and ultrasound heating
EP3071134A1 (en) 2013-11-19 2016-09-28 Ethicon, Inc. Thoracoscopic methods for treatment of bronchial disease
TW201521671A (zh) * 2013-12-11 2015-06-16 Univ Nat Taiwan 超音波醫療裝置
EP3099325A4 (en) 2014-01-31 2017-10-04 The General Hospital Corporation Dba Massachusetts General Hospital Methods of treating and imaging tumor micrometastases using photoactivatable immunoconjugates
AU2015247951A1 (en) 2014-04-18 2016-11-17 Ulthera, Inc. Band transducer ultrasound therapy
CA2973655C (en) 2015-01-15 2024-05-07 Rodney HERRING Diffuse acoustic confocal imager
CN104874114A (zh) 2015-06-01 2015-09-02 天津大学 一种利用低强度超声促进放射治疗效应的系统
CN114886412B (zh) 2015-06-03 2025-06-24 蒙特非奥里医疗中心 用于治疗癌症和转移的低强度聚焦超声
JP7100578B2 (ja) 2015-11-05 2022-07-13 ザ ジェネラル ホスピタル コーポレイション 腫瘍内免疫応答を増強することによってがんを治療するための方法
KR101875111B1 (ko) 2016-04-29 2018-07-09 한국수력원자력 주식회사 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제
US20180154183A1 (en) 2016-06-22 2018-06-07 Velayudhan Sahadevan Normal Tissue Toxicity Reducing Microbeam-Broadbeam Radiotherapy, Skin's Radio-Response Immunotherapy and Mutated Molecular Apheresis Combined Cancer Treatments
MX2019007727A (es) 2016-12-31 2019-08-29 Radiation Barrier Llc Reducción del daño de la radioterapia y aumento de las tasas de destrucción de cáncer entremezclando sesiones de baja y alta dosis.
CA3059991A1 (en) 2016-12-31 2018-07-05 Radiation Barrier Llc Reducing damage from chemotherapy and increasing cancer kill rates by using interweaved low dose radiation
CN111836666A (zh) 2017-11-09 2020-10-27 蒙特非奥里医疗中心 用于治疗癌症和转移的低能量免疫致敏
WO2020123388A1 (en) 2018-12-11 2020-06-18 Board Of Regents, The University Of Texas System Radiotherapies and uses thereof
EP4021568A4 (en) 2019-08-27 2023-11-01 Montefiore Medical Center Post-ablative modulation of radiation therapy

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11179581B2 (en) 2015-03-09 2021-11-23 The Research Foundation For The State University Of New York Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration
JP2021058618A (ja) * 2015-06-03 2021-04-15 モンテフィオーレ メディカル センターＭｏｎｔｅｆｉｏｒｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌と転移を処置するための低密度焦点式超音波
JP7105294B2 (ja) 2015-06-03 2022-07-22 モンテフィオーレ メディカル センター 癌と転移を処置するための低密度焦点式超音波
JP2022165965A (ja) * 2015-06-03 2022-11-01 モンテフィオーレ メディカル センター 癌と転移を処置するための低密度焦点式超音波
JP7635177B2 (ja) 2015-06-03 2025-02-25 モンテフィオーレ メディカル センター 癌と転移を処置するための低密度焦点式超音波
US12434076B2 (en) 2017-11-09 2025-10-07 Montefiore Medical Center Low energy immune priming for treating cancer and metastasis

Also Published As

Publication number Publication date
CN114886412A (zh) 2022-08-12
EP3302264A2 (en) 2018-04-11
WO2016196741A2 (en) 2016-12-08
WO2016196741A3 (en) 2017-05-04
CN108601554A (zh) 2018-09-28
JP7105294B2 (ja) 2022-07-22
EP3302264B1 (en) 2025-03-19
US10974077B2 (en) 2021-04-13
EP3302264A4 (en) 2019-02-20
US20240366964A1 (en) 2024-11-07
JP2022165965A (ja) 2022-11-01
CN114886412B (zh) 2025-06-24
CN108601554B (zh) 2022-03-08
US12011619B2 (en) 2024-06-18
US20210268315A1 (en) 2021-09-02
JP7635177B2 (ja) 2025-02-25
JP2021058618A (ja) 2021-04-15
US20180296859A1 (en) 2018-10-18
JP2018517495A (ja) 2018-07-05

Similar Documents

Publication Publication Date Title
JP6819012B2 (ja) 癌と転移を処置するための低密度焦点式超音波
US12434076B2 (en) Low energy immune priming for treating cancer and metastasis
Abdo et al. Immunotherapy plus cryotherapy: potential augmented abscopal effect for advanced cancers
Drake Combination immunotherapy approaches
Anzengruber et al. T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?
Bandyopadhyay et al. Low-intensity focused ultrasound induces reversal of tumor-induced T cell tolerance and prevents immune escape
De La Maza et al. In situ vaccination after accelerated hypofractionated radiation and surgery in a mesothelioma mouse model
Imran et al. Magic bubbles: utilizing histotripsy to modulate the tumor microenvironment and improve systemic anti-tumor immune responses
Preise et al. Antitumor immunity promoted by vascular occluding therapy: lessons from vascular-targeted photodynamic therapy (VTP)
Takahashi et al. Immunological effect of local ablation combined with immunotherapy on solid malignancies
Cao et al. Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Marabelle et al. Radiotherapy and toll-like receptor agonists
Imran et al. Exploration of novel pathways underlying irreversible electroporation induced anti-tumor immunity in pancreatic cancer
Liu et al. Modern cancer therapy: cryoablation meets immune checkpoint blockade
Byrne et al. CD40 therapy and surgery: a potential immunologic partnership
Nierkens et al. Radiofrequency ablation in cancer therapy: tuning in to in situ tumor vaccines
US20170021002A1 (en) Augmentation of cancer and cancer endothelial vaccine immunogenicity by histone deacetylase inhibitors
HK1261209B (zh) 用於治疗癌症和转移的低强度聚焦超声
HK1261209A1 (en) Low intensity focused ultrasound for treating cancer and metastasis
US20220133788A1 (en) Baff therapy to promote anti-tumor immunity
Guha et al. Immune system modulation with LOFU and HIFU treatment of prostate cancer
Alexander et al. Immune effects of ablation
Zhu et al. The combination of local treatment and immunotherapy
Skalina Generation of an In Situ Tumor Vaccine Using Focused Ultrasound-Induced Immune Priming
Singh Role of focused ultrasound in CD40 mediated anti-tumor immunity

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190529

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190530

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200522

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200608

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200903

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201116

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201211

R150 Certificate of patent or registration of utility model

Ref document number: 6819012

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250