JP6796059B2 - Ｗｎｔシグナリングアゴニスト分子 - Google Patents

Ｗｎｔシグナリングアゴニスト分子 Download PDF

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JP6796059B2
JP6796059B2 JP2017510495A JP2017510495A JP6796059B2 JP 6796059 B2 JP6796059 B2 JP 6796059B2 JP 2017510495 A JP2017510495 A JP 2017510495A JP 2017510495 A JP2017510495 A JP 2017510495A JP 6796059 B2 JP6796059 B2 JP 6796059B2
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binding domain
wnt
wnt signaling
fzd
cells
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JP2017530099A (ja
JP2017530099A5 (cg-RX-API-DMAC7.html
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クリストファー ガルシア，ケナン
クリストファー ガルシア，ケナン
デイビッド ベイカー，
デイビッド ベイカー，
クラウディア イヴォンヌ ジャンダ，
クラウディア イヴォンヌ ジャンダ，
ルーク ダン，
ルーク ダン，
ジェイムズ ダニエル ムーディー，
ジェイムズ ダニエル ムーディー，
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2318/00—Antibody mimetics or scaffolds
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JP2017510495A 2014-09-12 2015-09-11 Ｗｎｔシグナリングアゴニスト分子 Active JP6796059B2 (ja)

Applications Claiming Priority (5)

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US201462049949P 2014-09-12 2014-09-12
US62/049,949 2014-09-12
US201562206150P 2015-08-17 2015-08-17
US62/206,150 2015-08-17
PCT/US2015/049829 WO2016040895A1 (en) 2014-09-12 2015-09-11 Wnt signaling agonist molecules

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JP2017530099A JP2017530099A (ja) 2017-10-12
JP2017530099A5 JP2017530099A5 (cg-RX-API-DMAC7.html) 2018-09-13
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JP2020138446A Withdrawn JP2020186267A (ja) 2014-09-12 2020-08-19 Ｗｎｔシグナリングアゴニスト分子
JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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JP2023080152A Pending JP2023091081A (ja) 2014-09-12 2023-05-15 Ｗｎｔシグナリングアゴニスト分子

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US (4) US11142577B2 (cg-RX-API-DMAC7.html)
EP (2) EP4219564A1 (cg-RX-API-DMAC7.html)
JP (3) JP6796059B2 (cg-RX-API-DMAC7.html)
AU (2) AU2015314771B2 (cg-RX-API-DMAC7.html)
CA (1) CA2959045A1 (cg-RX-API-DMAC7.html)
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US20220064337A1 (en) * 2018-12-19 2022-03-03 Surrozen, Inc. Antigen binding formats for receptor complexes
EP3924381A4 (en) * 2019-02-11 2023-07-26 Surrozen Operating, Inc. MODULATION OF WNT SIGNALING IN EYE DISEASES
EP3938036A4 (en) * 2019-03-11 2023-06-28 Surrozen Operating, Inc. Modulation of wnt signaling in gastrointestinal disorders
KR20220024460A (ko) * 2019-06-11 2022-03-03 안틀라 테라퓨틱스 아이엔씨. 다가 fzd 및 wnt 결합 분자 및 이의 용도
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KR20230109668A (ko) 2020-11-16 2023-07-20 서로젠 오퍼레이팅, 인크. 간-특이적 Wnt 신호 증강 분자 및 그의 용도
US20240150473A1 (en) * 2021-03-10 2024-05-09 Surrozen Operating, Inc. Modulation of wnt signaling in gastrointestinal disorders
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WO2024227103A1 (en) * 2023-04-27 2024-10-31 Surrozen Operating, Inc. Molecules modulating wnt signaling pathways and uses thereof
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