JP6789578B2 - ５−ｈｔ２ｃ受容体アゴニストおよび組成物、ならびに使用方法 - Google Patents

５−ｈｔ２ｃ受容体アゴニストおよび組成物、ならびに使用方法 Download PDF

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JP6789578B2
JP6789578B2 JP2018504658A JP2018504658A JP6789578B2 JP 6789578 B2 JP6789578 B2 JP 6789578B2 JP 2018504658 A JP2018504658 A JP 2018504658A JP 2018504658 A JP2018504658 A JP 2018504658A JP 6789578 B2 JP6789578 B2 JP 6789578B2
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formula
individual
treatment
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JP2018522025A5 (cg-RX-API-DMAC7.html
JP2018522025A (ja
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ヨーグ レーマン，
ヨーグ レーマン，
コンラッド フェイヒティンガー，
コンラッド フェイヒティンガー，
アルバート エス． レン，
アルバート エス． レン，
グレアム センプル，
グレアム センプル，
Original Assignee
アリーナ ファーマシューティカルズ， インコーポレイテッド
アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018504658A 2015-07-31 2016-07-28 ５−ｈｔ２ｃ受容体アゴニストおよび組成物、ならびに使用方法 Expired - Fee Related JP6789578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199382P 2015-07-31 2015-07-31
US62/199,382 2015-07-31
PCT/US2016/044426 WO2017023679A1 (en) 2015-07-31 2016-07-28 5-ht2c receptor agonists and compositions and methods of use

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JP2018522025A JP2018522025A (ja) 2018-08-09
JP2018522025A5 JP2018522025A5 (cg-RX-API-DMAC7.html) 2019-08-15
JP6789578B2 true JP6789578B2 (ja) 2020-11-25

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US (4) US10272094B2 (cg-RX-API-DMAC7.html)
EP (1) EP3328835B1 (cg-RX-API-DMAC7.html)
JP (1) JP6789578B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180031035A (cg-RX-API-DMAC7.html)
CN (1) CN108137508B (cg-RX-API-DMAC7.html)
AU (1) AU2016302755B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018001707A2 (cg-RX-API-DMAC7.html)
CA (1) CA3002525A1 (cg-RX-API-DMAC7.html)
EA (1) EA039412B1 (cg-RX-API-DMAC7.html)
HK (1) HK1255850A1 (cg-RX-API-DMAC7.html)
IL (1) IL257107B (cg-RX-API-DMAC7.html)
MA (1) MA42527A (cg-RX-API-DMAC7.html)
MX (1) MX375045B (cg-RX-API-DMAC7.html)
WO (1) WO2017023679A1 (cg-RX-API-DMAC7.html)

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US10272094B2 (en) * 2015-07-31 2019-04-30 Arena Pharmaceuticals, Inc. 5-HT2C receptor agonists and compositions and methods of use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN110642721B (zh) * 2018-12-21 2022-09-30 安徽贝克生物制药有限公司 盐酸司来吉兰的制备方法
CN110668951B (zh) * 2018-12-21 2022-09-30 安徽贝克生物制药有限公司 一种盐酸司来吉兰的合成工艺
KR20220009954A (ko) 2019-04-17 2022-01-25 컴퍼스 패쓰파인더 리미티드 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법
US20220410894A1 (en) * 2021-06-29 2022-12-29 Tusimple, Inc. Systems and methods for operating an autonomous vehicle
US12311973B2 (en) 2021-10-14 2025-05-27 Tusimple, Inc. Systems and methods for operating an autonomous vehicle

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US5180733A (en) * 1990-03-30 1993-01-19 Abbott Laboratories Biogenic amine uptake inhibitors
WO1992018005A1 (en) 1991-04-16 1992-10-29 National Institutes Of Health Method of treating trichotillomania and onychophagia
CA2482195A1 (en) 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
TW200307682A (en) * 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
EP2098512A1 (en) * 2003-10-08 2009-09-09 Eli Lilly & Company Compounds and methods for treating dyslipidemia
WO2011071136A1 (ja) * 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
WO2013133325A1 (ja) * 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
HK1212684A1 (zh) * 2012-09-14 2016-06-17 AbbVie Deutschland GmbH & Co. KG 三環喹啉和喹喔啉衍生物
US10272094B2 (en) 2015-07-31 2019-04-30 Arena Pharmaceuticals, Inc. 5-HT2C receptor agonists and compositions and methods of use

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Publication number Publication date
HK1255850A1 (zh) 2019-08-30
WO2017023679A1 (en) 2017-02-09
MA42527A (fr) 2021-04-07
KR20180031035A (ko) 2018-03-27
CA3002525A1 (en) 2017-02-09
US10624900B2 (en) 2020-04-21
US20230055376A1 (en) 2023-02-23
AU2016302755B2 (en) 2020-09-10
MX375045B (es) 2025-03-06
US10272094B2 (en) 2019-04-30
EP3328835B1 (en) 2022-10-12
EA201890402A1 (ru) 2018-09-28
US20200078368A1 (en) 2020-03-12
IL257107A (en) 2018-03-29
CN108137508B (zh) 2021-08-27
BR112018001707A2 (pt) 2018-09-18
EA039412B1 (ru) 2022-01-25
EP3328835A1 (en) 2018-06-06
AU2016302755A1 (en) 2018-03-15
CN108137508A (zh) 2018-06-08
US20180214455A1 (en) 2018-08-02
JP2018522025A (ja) 2018-08-09
NZ739883A (en) 2021-03-26
US11395824B2 (en) 2022-07-26
MX2018001380A (es) 2018-06-15
US20200383993A1 (en) 2020-12-10
IL257107B (en) 2021-03-25

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