JP6783247B2 - ガン予防における短鎖脂肪酸の使用 - Google Patents

ガン予防における短鎖脂肪酸の使用 Download PDF

Info

Publication number
JP6783247B2
JP6783247B2 JP2017557279A JP2017557279A JP6783247B2 JP 6783247 B2 JP6783247 B2 JP 6783247B2 JP 2017557279 A JP2017557279 A JP 2017557279A JP 2017557279 A JP2017557279 A JP 2017557279A JP 6783247 B2 JP6783247 B2 JP 6783247B2
Authority
JP
Japan
Prior art keywords
cancer
acid
pharmaceutically acceptable
hbx
liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017557279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504457A (ja
JP2018504457A5 (enExample
Inventor
ファイテルソン，マーク・エー．
ヘイス，エレナ・エミ．ジェー．ぺー．ヴェー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2018504457A publication Critical patent/JP2018504457A/ja
Publication of JP2018504457A5 publication Critical patent/JP2018504457A5/ja
Application granted granted Critical
Publication of JP6783247B2 publication Critical patent/JP6783247B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Non-Alcoholic Beverages (AREA)
JP2017557279A 2015-01-23 2016-01-21 ガン予防における短鎖脂肪酸の使用 Active JP6783247B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106778P 2015-01-23 2015-01-23
US62/106,778 2015-01-23
PCT/US2016/014292 WO2016118730A1 (en) 2015-01-23 2016-01-21 Use of short chain fatty acids in cancer prevention

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020176442A Division JP2021020929A (ja) 2015-01-23 2020-10-21 ガン予防における短鎖脂肪酸の使用

Publications (3)

Publication Number Publication Date
JP2018504457A JP2018504457A (ja) 2018-02-15
JP2018504457A5 JP2018504457A5 (enExample) 2019-02-28
JP6783247B2 true JP6783247B2 (ja) 2020-11-11

Family

ID=56417737

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017557279A Active JP6783247B2 (ja) 2015-01-23 2016-01-21 ガン予防における短鎖脂肪酸の使用
JP2020176442A Pending JP2021020929A (ja) 2015-01-23 2020-10-21 ガン予防における短鎖脂肪酸の使用
JP2022196339A Pending JP2023027219A (ja) 2015-01-23 2022-12-08 ガン予防における短鎖脂肪酸の使用
JP2024220908A Pending JP2025038120A (ja) 2015-01-23 2024-12-17 ガン予防における短鎖脂肪酸の使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020176442A Pending JP2021020929A (ja) 2015-01-23 2020-10-21 ガン予防における短鎖脂肪酸の使用
JP2022196339A Pending JP2023027219A (ja) 2015-01-23 2022-12-08 ガン予防における短鎖脂肪酸の使用
JP2024220908A Pending JP2025038120A (ja) 2015-01-23 2024-12-17 ガン予防における短鎖脂肪酸の使用

Country Status (12)

Country Link
US (6) US10231941B2 (enExample)
EP (1) EP3247342B1 (enExample)
JP (4) JP6783247B2 (enExample)
KR (1) KR102735818B1 (enExample)
CN (2) CN107405321A (enExample)
AU (3) AU2016209244A1 (enExample)
IL (1) IL253581A0 (enExample)
MX (1) MX387817B (enExample)
RU (1) RU2017127597A (enExample)
SG (2) SG11201705953XA (enExample)
WO (1) WO2016118730A1 (enExample)
ZA (1) ZA201704977B (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
CA2964480A1 (en) 2014-10-31 2016-05-06 Whole Biome Inc. Methods and compositions relating to microbial treatment and diagnosis of disorders
EP3400953A1 (en) 2014-12-23 2018-11-14 4D Pharma Research Limited Pirin polypeptide and immune modulation
AR103260A1 (es) 2014-12-23 2017-04-26 4D Pharma Res Ltd Modulación inmunitaria
SMT201900588T1 (it) 2015-06-15 2019-11-13 4D Pharma Res Limited Blautia stercoris e wexlerae per uso nel trattamento di malattie infiammatorie ed autoimmuni
WO2016203221A1 (en) 2015-06-15 2016-12-22 4D Pharma Research Limited Compositions comprising bacterial strains
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
NZ737752A (en) 2015-06-15 2022-02-25 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
CN108513545B (zh) 2015-11-20 2020-11-03 4D制药研究有限公司 包含细菌菌株的组合物
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
ME03487B (me) 2016-03-04 2020-01-20 4D Pharma Plc Kompozicije koje sadrže blautia bakterijske sojeve za liječenje visceralne hipersenzitivnosti
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
TWI802545B (zh) 2016-07-13 2023-05-21 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
WO2018089861A1 (en) * 2016-11-11 2018-05-17 The Regents Of The University Of California Methods and compositions for the treatment of cancer and metabolic diseases
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
US11065217B2 (en) 2017-01-27 2021-07-20 Temple University—Of the Commonwealth System of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
JP7136807B2 (ja) 2017-04-17 2022-09-13 ザ・ユニバーシティ・オブ・シカゴ ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料
US20220304967A1 (en) * 2017-04-24 2022-09-29 Allerpops Oral microbiota promoting composition cross-reference to related applications
DK3630136T3 (da) 2017-05-22 2021-05-25 4D Pharma Res Ltd Sammensætninger, der omfatter bakteriestammer
EP3630942B1 (en) 2017-05-24 2022-11-30 4D Pharma Research Limited Compositions comprising bacterial strain
SMT202000555T1 (it) 2017-06-14 2020-11-10 4D Pharma Res Limited Composizioni comprendenti un ceppo batterico del genere megaspaera e loro usi
SMT202000695T1 (it) 2017-06-14 2021-01-05 4D Pharma Res Limited Composizioni comprendenti ceppi batterici
CA3066189A1 (en) 2017-06-14 2018-12-20 4D Pharma Research Limited Compositions comprising bacterial strains
TW201906620A (zh) 2017-07-05 2019-02-16 美商艾弗洛生物科技股份有限公司 使用動物雙岐桿菌乳亞種 (bifidobacterium animalis ssp. lactis) 治療癌症之組合物及方法
MX2019014315A (es) 2017-08-04 2020-02-03 Nestle Sa Bacterias probioticas preacondicionadas en un medio que contiene gos y uso de estas.
JP2020532515A (ja) 2017-08-30 2020-11-12 ペンデュラム セラピューティクス， インコーポレイテッド マイクロバイオーム関連障害の処置のための方法および組成物
CN110090230B (zh) * 2018-01-30 2022-07-12 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
PL3743086T3 (pl) * 2018-05-11 2022-06-20 4D Pharma Research Limited Kompozycje zawierające szczepy bakteryjne
WO2019232513A1 (en) * 2018-06-01 2019-12-05 Evolve Biosystems, Inc. Compositions and methods to promote host defense and stimulate, expand, and/or reset t cell repertoires
EP3823651A4 (en) 2018-07-19 2022-04-27 Pendulum Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MICROBIAL TRANSPLANTATION
US20220364056A1 (en) * 2019-09-25 2022-11-17 Philipps-Universität Marburg Short-chain fatty acid pentanoate as enhancer for cellular therapy and anti-tumor therapy
KR102510198B1 (ko) * 2019-11-14 2023-03-15 가톨릭대학교 산학협력단 락토바실러스 속 균주 및 SCFA(Short fatty chain acid)를 포함하는 면역 질환의 예방 및 치료용 조성물
TWI734341B (zh) * 2020-01-14 2021-07-21 景岳生物科技股份有限公司 一種副乾酪乳桿菌ｇｍｎｌ-３４６用於抗口腔癌之用途
US20230120406A1 (en) * 2020-03-05 2023-04-20 Liscure Biosciences Co., Ltd. Pharmaceutical composition for prevention or treatment of cancer comprising leuconostoc sp. as active ingredient
US20240009154A1 (en) * 2020-08-04 2024-01-11 Temple University-Of The Commonwealth System Of Higher Education Methods and compositions for treating cytokine release syndrome
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
AU2021380836A1 (en) * 2020-11-12 2023-06-22 Alla ARZUMANYAN Use of short chain fatty acids in cancer prevention
WO2022177409A1 (ko) * 2021-02-22 2022-08-25 주식회사 리스큐어바이오사이언시스 류코노스톡 메센테로이데스 균주 유래 나노소포체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
GB2631853A (en) * 2022-01-19 2025-01-15 Hodgdon Ian Short-chain fatty acids for cancer treatment
CN117925434B (zh) * 2022-10-26 2025-02-14 慕恩（广州）生物科技有限公司 粪肠球菌mnh 22871及其应用
CN116212027A (zh) * 2023-02-28 2023-06-06 西湖大学 一种调控Treg细胞内铁水平的试剂的用途
WO2025176152A1 (en) * 2024-02-19 2025-08-28 The University Of Hong Kong Probiotics mixtures and methods of use thereof for treating cancers
CN119424400B (zh) * 2024-10-21 2026-03-03 江南大学 缓解衰老的肠道菌群支链氨基酸代谢产物异丁酸和异戊酸及其应用
CN119258047A (zh) * 2024-11-26 2025-01-07 哈尔滨医科大学 琥珀酸在制备防治肝癌药物中的新用途

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735967A (en) 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
AU645070B2 (en) 1990-04-10 1994-01-06 Nb International Technologies Use of short chain fatty acid containing lipids to maintain gastrointestinal integrity and function in patients DO NOT SEAL - SEE LETTER DATED 22.03.94
PH31403A (en) 1991-03-01 1998-10-29 Warner Lambert Co Therapeutic compositions to protect and recuscitate mammalian cells and methods for preparing same.
WO1995011699A1 (en) 1993-10-29 1995-05-04 The Trustees Of Boston University Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
JP2000072667A (ja) 1998-08-25 2000-03-07 Kurasuraa:Kk 大腸炎治療用経口投与剤
US6201077B1 (en) 1998-12-01 2001-03-13 Phillips Petroleum Company Process that produces polymers
EP1034788A1 (en) 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Lactic acid bacteria strains capable of preventing diarrhea
JP4360915B2 (ja) 2002-01-07 2009-11-11 ユーロスクリーン・ソシエテ・アノニム Ｇタンパク質共役受容体ｇｐｒ４３のリガンドおよびその使用
CN101259120B (zh) 2002-03-04 2012-07-04 Hdac默克研究有限责任公司 辛二酰苯胺异羟肟酸或其可药用盐在制备诱导末期分化的药物的用途
AU2003226408B2 (en) 2002-04-15 2007-06-14 Sloan-Kettering Institute For Cancer Research Combination therapy for the treatment of cancer
US8846039B2 (en) 2002-04-26 2014-09-30 Asan Laboratories Company (Cayman), Limited Method for ameliorating pruritus
CN1681505A (zh) 2002-09-13 2005-10-12 弗吉尼亚州立大学 用于治疗白血病的а ) N－{ 5－[ 4－( 4－甲基－哌嗪－1－基－甲基)－苯甲酰氨基]－2－甲基苯基}－4－( 3－吡啶基 ) －2－嘧啶－胺和b )组蛋白脱乙酰基酶抑制剂的组合
US20050023179A1 (en) 2003-07-31 2005-02-03 Albritton Charles Wade Fragile-product cage for vacuum packaging appliances
CN102349927A (zh) 2003-08-29 2012-02-15 Hdac默克研究有限责任公司 联合治疗癌症的方法
WO2007016953A1 (en) 2005-07-29 2007-02-15 Matuschka-Greiffenclau Markus Composition for reducing alcohol induced liver cancer risk
ES2444890T3 (es) * 2006-03-31 2014-02-27 Erasmus University Medical Center Rotterdam Nueva composición para el control del crecimiento tumoral
WO2008054293A1 (en) * 2006-11-03 2008-05-08 Salutary Care Limited Composition, its use for treating systemic diseases a conditions, and product containing said composition
US20080153908A1 (en) 2006-12-20 2008-06-26 Jani Dharmendra M Method of Treating Mucin Deficiency with an Active Pharmaceutical and Related Composition
WO2009087474A2 (en) 2008-01-08 2009-07-16 Akthelia Pharmaceuticals Agonists for antimicrobial peptide systems
CN101214234B (zh) * 2008-01-10 2010-09-08 中国人民解放军第二军医大学 α-羟基酸在制备癌瘤体内注射治疗药物中的应用
US9339667B2 (en) 2009-02-18 2016-05-17 Sea Qiq As Mixture of inorganic compounds, preparations containing the mixture and use of the mixture
CN104784220A (zh) 2009-06-19 2015-07-22 杜邦营养生物科学有限公司 治疗糖尿病及相关病症的双歧杆菌
US8962686B2 (en) 2010-04-28 2015-02-24 The Chinese University Of Hong Kong Method and medication for prevention and treatment of ocular hypertension and glaucoma
EP2389932A1 (en) 2010-05-28 2011-11-30 Lunamed AG Compositions for use in genetic disorders comprising 4-phenyl-butyric acid and its salts
WO2012013495A1 (en) 2010-07-29 2012-02-02 Cosmo Technologies Ltd. Pharmaceutical and/or dietary compositions based on short chain fatty acids
KR101747815B1 (ko) 2010-11-29 2017-06-15 유니버시티 푸트라 말레이지아 종양 세포독성제 및 그 방법
CN103687604A (zh) * 2011-03-01 2014-03-26 群体创新有限责任公司 用于治疗与致病生物膜相关之病症的材料和方法
WO2012131069A1 (en) 2011-03-31 2012-10-04 Proponent Biotech Gmbh Short chain fatty acids and their derivatives for use in treatment immunogenic disorders
US9402820B2 (en) * 2011-04-22 2016-08-02 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
CA3208225A1 (en) 2012-01-16 2013-07-25 Elizabeth Mckenna Compositions and methods for the treatment of hepatitic diseases and disorders
GB201215289D0 (en) 2012-08-28 2012-10-10 Medical Res Council Nanoparticle formulation
TWI463986B (zh) 2012-08-29 2014-12-11 Univ China Medical 胚芽乳酸桿菌ｃｍｕ９９５菌株之新用途
WO2015006355A2 (en) 2013-07-09 2015-01-15 Puretech Ventures, Llc Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
EP3033091B1 (en) 2013-08-16 2022-09-07 Versitech Limited Probiotic composition and use thereof in the prevention and treatment of hepatocellular carcinoma

Also Published As

Publication number Publication date
JP2025038120A (ja) 2025-03-18
JP2018504457A (ja) 2018-02-15
SG10201907660YA (en) 2019-10-30
AU2016209244A1 (en) 2017-08-17
KR102735818B1 (ko) 2024-11-28
ZA201704977B (en) 2022-12-21
EP3247342A1 (en) 2017-11-29
US20180185307A1 (en) 2018-07-05
US20220008369A1 (en) 2022-01-13
US10143669B2 (en) 2018-12-04
US20180008565A1 (en) 2018-01-11
JP2021020929A (ja) 2021-02-18
IL253581A0 (en) 2017-09-28
AU2020239699A1 (en) 2020-10-15
CN107405321A (zh) 2017-11-28
RU2017127597A (ru) 2019-02-25
EP3247342B1 (en) 2026-01-07
US20190160031A1 (en) 2019-05-30
WO2016118730A1 (en) 2016-07-28
CN115350171A (zh) 2022-11-18
MX2017009532A (es) 2018-04-10
EP3247342A4 (en) 2018-10-10
JP2023027219A (ja) 2023-03-01
MX387817B (es) 2025-03-11
KR20170128247A (ko) 2017-11-22
US11963938B2 (en) 2024-04-23
RU2017127597A3 (enExample) 2019-07-17
US10231941B2 (en) 2019-03-19
AU2019201799A1 (en) 2019-04-04
AU2019201799B2 (en) 2020-10-15
US20240342122A1 (en) 2024-10-17
SG11201705953XA (en) 2017-08-30
US20250213508A1 (en) 2025-07-03
CA2974510A1 (en) 2016-07-28

Similar Documents

Publication Publication Date Title
JP6783247B2 (ja) ガン予防における短鎖脂肪酸の使用
US11759442B2 (en) Use of short chain fatty acids for the treatment and prevention of diseases and disorders
JP7688360B2 (ja) 疾患及び障害の処置及び予防のための短鎖脂肪酸の使用
JP2021514968A (ja) 微生物関連の免疫療法
JP2022078078A (ja) 天然に存在するＣｐＧオリゴヌクレオチド組成物およびその治療的適用
CA3167386A1 (en) A bacterial composition for the treatment of cancer
HK40082664A (en) Use of short chain fatty acids in cancer prevention
CA2974510C (en) Use of short chain fatty acids in cancer prevention
HK1240857A1 (en) Use of short chain fatty acids in cancer prevention
JP2022177817A (ja) ケトン供与体を含む組成物
JP2024075031A (ja) ケトン供与体を含む組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190117

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200325

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200512

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200811

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200923

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201021

R150 Certificate of patent or registration of utility model

Ref document number: 6783247

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250