JP6780910B2 - 細胞間空間的近接を導き出すためのコンピュータ方法及びシステム - Google Patents

細胞間空間的近接を導き出すためのコンピュータ方法及びシステム Download PDF

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JP6780910B2
JP6780910B2 JP2018521297A JP2018521297A JP6780910B2 JP 6780910 B2 JP6780910 B2 JP 6780910B2 JP 2018521297 A JP2018521297 A JP 2018521297A JP 2018521297 A JP2018521297 A JP 2018521297A JP 6780910 B2 JP6780910 B2 JP 6780910B2
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JP2019500583A5 (enExample
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リトル・ブライアン
ボルドー・ジェニファー
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Novartis AG
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
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    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion

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JP2018521297A 2015-10-23 2016-10-21 細胞間空間的近接を導き出すためのコンピュータ方法及びシステム Active JP6780910B2 (ja)

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US201562245933P 2015-10-23 2015-10-23
US62/245,933 2015-10-23
US201562259326P 2015-11-24 2015-11-24
US62/259,326 2015-11-24
PCT/US2016/058278 WO2017070582A1 (en) 2015-10-23 2016-10-21 Computer method and system for deriving cell-to-cell spatial proximities

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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
US10533953B2 (en) * 2016-04-04 2020-01-14 Kla-Tencor Corporation System and method for wafer inspection with a noise boundary threshold
WO2018063914A1 (en) * 2016-09-29 2018-04-05 Animantis, Llc Methods and apparatus for assessing immune system activity and therapeutic efficacy
JP7162600B2 (ja) * 2017-02-06 2022-10-28 ノヴァルティス アーゲー 免疫療法に対する応答を予測する方法
CN110945561B (zh) * 2017-06-13 2024-06-14 爱色丽公司 高光谱成像分光光度计和系统
AU2018298890B2 (en) * 2017-07-13 2025-03-13 Institut Gustave-Roussy A radiomics-based imaging tool to monitor tumor-lymphocyte infiltration and outcome in cancer patients treated by anti-PD-1/PD- L1
US20210396739A1 (en) 2018-05-01 2021-12-23 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
US11246527B2 (en) 2018-08-31 2022-02-15 Seno Medical Instruments, Inc. Method and system for managing feature reading and scoring in ultrasound and/or optoacoustice images
US11375984B2 (en) 2018-08-31 2022-07-05 Seno Medical Instruments, Inc. Method and system for managing feature reading and scoring in ultrasound and/or optoacoustic images
EP3693974A1 (en) * 2019-02-07 2020-08-12 Koninklijke Philips N.V. Identifying responsiveness to radio-immuno combination therapy
WO2020257482A1 (en) * 2019-06-19 2020-12-24 Seno Medical Instruments, Inc. Method and system for managing feature reading and scoring in ultrasound and/or optoacoustice images
US11908130B2 (en) * 2020-01-03 2024-02-20 Protein Metrics Llc Apparatuses and methods for digital pathology
CN113192553B (zh) * 2020-01-14 2022-09-09 北京大学 基于单细胞转录组测序数据预测细胞空间关系的方法
AU2021213131B2 (en) * 2020-01-28 2023-02-02 PAIGE.AI, Inc. Systems and methods for processing electronic images for biomarker localization
IL296775A (en) * 2020-03-30 2022-11-01 Security Matters Ltd A method and system for marking and reading electronic systems with an x-wave marker
US11683098B2 (en) * 2020-07-14 2023-06-20 Raytheon Company Spectrally beam-combined, fiber-based multi-wavelength receiver/transceiver
US12254673B1 (en) * 2021-01-19 2025-03-18 Given Imaging Ltd Systems and methods for classifying or selecting images based on image segmentation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
JP4309183B2 (ja) 2003-06-18 2009-08-05 Ｎｅｃインフロンティア株式会社 指紋入力装置
US7264794B2 (en) * 2004-12-17 2007-09-04 The General Hospital Methods of in vivo cytometry
EP2227774B1 (en) * 2007-12-04 2014-07-09 University College Dublin, National University of Ireland Dublin Method and system for image analysis
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US9240043B2 (en) * 2008-09-16 2016-01-19 Novartis Ag Reproducible quantification of biomarker expression
JP5569206B2 (ja) * 2010-07-15 2014-08-13 ソニー株式会社 画像処理装置および方法
FR2964744B1 (fr) * 2010-09-10 2015-04-03 Univ Versailles St Quentin En Yvelines Test pronostic de l'evolution d'une tumeur solide par analyse d'images
AU2011336707A1 (en) * 2010-11-29 2013-07-04 Dako Denmark A/S Methods and systems for analyzing images of specimens processed by a programmable quantitative assay
WO2012166824A2 (en) * 2011-05-31 2012-12-06 Oregon Health And Science University Methods and kits that identify tumors responsive to src inhibitors
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
DE102012005654B4 (de) * 2011-10-25 2021-03-04 Schott Ag Optischer Konverter für hohe Leuchtdichten
EP2773962B1 (en) * 2011-11-04 2016-09-14 Invivis SAS Assay for predictive biomarkers of anti-estrogen efficacy
EP3435084B1 (en) * 2012-08-16 2023-02-22 Decipher Biosciences, Inc. Prostate cancer prognostics using biomarkers
US9370328B2 (en) * 2012-11-29 2016-06-21 University Of Washington Through Its Center For Commercialization Methods and systems for determining tumor boundary characteristics
WO2015088930A1 (en) * 2013-12-10 2015-06-18 Merck Sharp & Dohme Corp. Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue
AU2015220731A1 (en) * 2014-02-21 2016-07-07 Ventana Medical Systems, Inc. Medical image analysis for identifying biomarker-positive tumor cells

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EP3365682B1 (en) 2020-10-07
JP6977130B2 (ja) 2021-12-08
EP3365682A4 (en) 2019-04-24
CN108463727B (zh) 2021-06-18
AU2016342355B2 (en) 2022-07-28
US20220170905A1 (en) 2022-06-02
ES2837015T3 (es) 2021-06-29
EP3365682A1 (en) 2018-08-29
CN108463727A (zh) 2018-08-28
AU2016342355A1 (en) 2018-05-17
US11747319B2 (en) 2023-09-05
US20180306768A1 (en) 2018-10-25
WO2017070582A1 (en) 2017-04-27
US10712331B2 (en) 2020-07-14
JP2021012208A (ja) 2021-02-04
US11249066B2 (en) 2022-02-15
JP2019500583A (ja) 2019-01-10
US20200300834A1 (en) 2020-09-24

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