JP6779793B2 - リンパ腫を治療するためのｅｚｈ２阻害剤 - Google Patents

リンパ腫を治療するためのｅｚｈ２阻害剤 Download PDF

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JP6779793B2
JP6779793B2 JP2016573564A JP2016573564A JP6779793B2 JP 6779793 B2 JP6779793 B2 JP 6779793B2 JP 2016573564 A JP2016573564 A JP 2016573564A JP 2016573564 A JP2016573564 A JP 2016573564A JP 6779793 B2 JP6779793 B2 JP 6779793B2
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lymphoma
pharmaceutical composition
nhl
ezh2
composition according
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JP2017518334A (ja
JP2017518334A5 (index.php
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カイルハック ハイケ
カイルハック ハイケ
オデセン ローン
オデセン ローン
レイデルマン ラリッサ
レイデルマン ラリッサ
ケー． ナットソン サラ
ケー． ナットソン サラ
エル． ジョンストン ダニエル
エル． ジョンストン ダニエル
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016573564A 2014-06-17 2015-06-17 リンパ腫を治療するためのｅｚｈ２阻害剤 Active JP6779793B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462013522P 2014-06-17 2014-06-17
US62/013,522 2014-06-17
US201462036265P 2014-08-12 2014-08-12
US62/036,265 2014-08-12
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

Publications (3)

Publication Number Publication Date
JP2017518334A JP2017518334A (ja) 2017-07-06
JP2017518334A5 JP2017518334A5 (index.php) 2018-08-09
JP6779793B2 true JP6779793B2 (ja) 2020-11-04

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JP2016573564A Active JP6779793B2 (ja) 2014-06-17 2015-06-17 リンパ腫を治療するためのｅｚｈ２阻害剤

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US (5) US10166238B2 (index.php)
EP (2) EP3157527B1 (index.php)
JP (1) JP6779793B2 (index.php)
KR (2) KR102497728B1 (index.php)
CN (2) CN113289022A (index.php)
AU (3) AU2015277139A1 (index.php)
BR (1) BR112016029492A2 (index.php)
CA (1) CA2952074C (index.php)
DK (1) DK3157527T3 (index.php)
EA (1) EA038337B1 (index.php)
ES (1) ES2948442T3 (index.php)
FI (1) FI3157527T3 (index.php)
HU (1) HUE062158T2 (index.php)
IL (3) IL285201B2 (index.php)
LT (1) LT3157527T (index.php)
MX (2) MX383866B (index.php)
PL (1) PL3157527T3 (index.php)
PT (1) PT3157527T (index.php)
SG (2) SG11201610273VA (index.php)
SI (1) SI3157527T1 (index.php)
WO (1) WO2015195848A1 (index.php)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
IL308613A (en) 2012-10-15 2024-01-01 Epizyme Inc Cancer treatment methods
EP3888659A1 (en) 2013-12-06 2021-10-06 Epizyme Inc Combination therapy for treating cancer
AU2015277139A1 (en) 2014-06-17 2016-12-22 Epizyme, Inc. EZH2 inhibitors for treating lymphoma
SG10201903356XA (en) 2014-10-16 2019-05-30 Epizyme Inc Method for treating cancer
EP3220916B1 (en) * 2014-11-17 2023-04-19 Epizyme, Inc. Method for treating cancer with n-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl) amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
AR102767A1 (es) 2014-12-05 2017-03-22 Lilly Co Eli Inhibidores de ezh2
SG11201708286PA (en) 2015-04-20 2017-11-29 Epizyme Inc Combination therapy for treating cancer
CA2988816A1 (en) * 2015-06-10 2016-12-15 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
KR20180042356A (ko) 2015-08-24 2018-04-25 에피자임, 인코포레이티드 암 치료 방법
TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
US11951108B2 (en) 2016-01-29 2024-04-09 Epizyme, Inc. Combination therapy for treating cancer
WO2017210395A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
EP3471830A4 (en) * 2016-06-17 2020-02-26 Epizyme Inc EZH2 INHIBITORS TO TREAT CANCER
JP2020506905A (ja) * 2017-01-20 2020-03-05 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． （ｒ）−ｎ−（（４−メトキシ−６−メチル−２−オキソ−１，２−ジヒドロピリジン−３−イル）メチル）−２−メチル−１−（１−（１−（２，２，２−トリフルオロエチル）ピペリジン−４−イル）エチル）−１ｈ−インドール−３−カルボキサミド固体分散液
WO2018183885A1 (en) 2017-03-31 2018-10-04 Epizyme, Inc. Combination therapy for treating cancer
EP3630080A4 (en) 2017-06-02 2021-03-10 Epizyme, Inc. USE OF EZH2 INHIBITORS TO TREAT CANCER
WO2019014191A1 (en) * 2017-07-10 2019-01-17 Constellation Pharmaceuticals, Inc. GENE EXPRESSION INDUCED BY EZH2 INHIBITOR
EP3678663A4 (en) 2017-09-05 2021-06-02 Epizyme, Inc. POLYTHERAPY FOR CANCER TREATMENT
EP4017527A1 (en) * 2019-08-22 2022-06-29 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
CN110950834A (zh) * 2019-11-26 2020-04-03 济南大学 新型eed-ezh2相互作用小分子抑制剂的确定和评价
CN110960525A (zh) * 2019-11-26 2020-04-07 济南大学 新型eed-ezh2相互作用抑制剂的确定和评价
EP4157466A4 (en) * 2020-05-28 2024-07-31 Epizyme, Inc. USE OF EZH2 INHIBITORS TO TREAT CANCER
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
AU2024322786A1 (en) 2023-08-07 2026-02-12 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
DK2614369T3 (en) 2010-09-10 2016-05-02 Epizyme Inc METHOD FOR DETERMINING THE SUITABILITY OF HUMAN EZH2 INHIBITORS TREATED
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
EP3323820B1 (en) 2011-02-28 2023-05-10 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
KR20140082742A (ko) 2011-09-30 2014-07-02 글락소스미스클라인 엘엘씨 암을 치료하는 방법
TR201904660T4 (tr) * 2012-03-12 2019-05-21 Epizyme Inc İnsan EZH2 inhibitörleri ve bunun kullanım yöntemleri.
MX367793B (es) 2012-04-13 2019-09-06 Epizyme Inc Terapia de combinación para tratar cáncer.
RS55690B1 (sr) 2012-04-13 2017-07-31 Epizyme Inc So inhibitora ljudske histonske metiltransferaze ezh2
WO2013173441A2 (en) 2012-05-16 2013-11-21 Glaxosmithkline Llc Enhancer of zeste homolog 2 inhibitors
IL308613A (en) * 2012-10-15 2024-01-01 Epizyme Inc Cancer treatment methods
EP2906538A4 (en) 2012-10-15 2016-05-11 Epizyme Inc SUBSTITUTED BENZOL COMPOUNDS
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US20150283142A1 (en) 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
SI2914296T2 (sl) * 2012-11-01 2022-01-31 Infinity Pharmaceuticals, Inc. Zdravljenje raznih vrst raka z uporabo modulatorjev izooblik PI3-kinaze
EP2934531A4 (en) 2012-12-19 2016-06-15 Glaxosmithkline Llc COMBINATION
WO2014100665A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone bicyclic heteroaryl compounds
CA2894216A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone compounds
EP2970306A4 (en) 2013-03-15 2016-08-03 Epizyme Inc SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS
US20160031907A1 (en) 2013-03-15 2016-02-04 Epizyme, Inc. Substituted Benzene Compounds
RU2705204C2 (ru) 2013-05-30 2019-11-06 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ piз-киназы
EP3022184B1 (en) 2013-07-19 2017-09-27 Epizyme, Inc. Substituted benzene compounds
WO2015010078A2 (en) 2013-07-19 2015-01-22 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
CN105593378B (zh) 2013-10-09 2019-09-20 豪夫迈·罗氏有限公司 用于在人ezh2基因中检测突变的方法和组合物
EP4324525A3 (en) 2013-10-16 2024-07-17 Epizyme, Inc. Hydrochloride salt form for ezh2 inhibition
EP3057594A4 (en) 2013-10-18 2017-06-07 Epizyme, Inc. Method of treating cancer
EP3888659A1 (en) 2013-12-06 2021-10-06 Epizyme Inc Combination therapy for treating cancer
AU2015277139A1 (en) 2014-06-17 2016-12-22 Epizyme, Inc. EZH2 inhibitors for treating lymphoma
BR112017009440A2 (pt) 2014-11-06 2017-12-19 Dana Farber Cancer Inst Inc uso de composições que modulam a estrutura de cromatina quanto à doença do enxerto versus hospedeiro (gvhd)
EP3220916B1 (en) 2014-11-17 2023-04-19 Epizyme, Inc. Method for treating cancer with n-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl) amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
JP6544507B2 (ja) 2015-02-09 2019-07-17 日本精機株式会社 ヘッドアップディスプレイ装置
CA2988816A1 (en) 2015-06-10 2016-12-15 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
KR20170095656A (ko) 2016-02-15 2017-08-23 동부대우전자 주식회사 방열구조를 갖는 세탁기

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MX2021007651A (es) 2021-08-11
IL285201B2 (en) 2024-05-01
PL3157527T3 (pl) 2023-08-07
DK3157527T3 (da) 2023-07-03
US10166238B2 (en) 2019-01-01
BR112016029492A2 (pt) 2017-10-17
IL285201A (en) 2021-08-31
EP4252851A3 (en) 2023-11-22
ES2948442T3 (es) 2023-09-12
EA201692285A1 (ru) 2017-06-30
AU2015277139A1 (en) 2016-12-22
CA2952074C (en) 2022-08-30
FI3157527T3 (fi) 2023-07-25
IL285201B1 (en) 2024-01-01
KR20230031963A (ko) 2023-03-07
US20240058348A1 (en) 2024-02-22
JP2017518334A (ja) 2017-07-06
CA2952074A1 (en) 2015-12-23
US20170216300A1 (en) 2017-08-03
US20200323866A1 (en) 2020-10-15
IL309539A (en) 2024-02-01
AU2020244382A1 (en) 2020-10-29
CN106999498B (zh) 2021-06-08
US20190175604A1 (en) 2019-06-13
SG10201811128RA (en) 2019-01-30
AU2022263523A1 (en) 2022-12-08
EP4252851A2 (en) 2023-10-04
EA201692285A8 (ru) 2018-01-31
WO2015195848A8 (en) 2016-07-07
SG11201610273VA (en) 2017-01-27
WO2015195848A1 (en) 2015-12-23
SI3157527T1 (sl) 2023-09-29
EP3157527B1 (en) 2023-05-24
HUE062158T2 (hu) 2023-10-28
KR20170052558A (ko) 2017-05-12
PT3157527T (pt) 2023-06-30
AU2020244382B2 (en) 2022-08-04
MX383866B (es) 2025-03-14
EP3157527A1 (en) 2017-04-26
CN113289022A (zh) 2021-08-24
EA038337B1 (ru) 2021-08-11
MX2016016744A (es) 2017-11-30
EP3157527A4 (en) 2018-05-23
US20200022987A1 (en) 2020-01-23
CN106999498A (zh) 2017-08-01
IL249438A0 (en) 2017-02-28
LT3157527T (lt) 2023-07-25
NZ727108A (en) 2023-09-29
US11642347B2 (en) 2023-05-09

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