JP6779793B2 - リンパ腫を治療するためのｅｚｈ２阻害剤 - Google Patents

リンパ腫を治療するためのｅｚｈ２阻害剤 Download PDF

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JP6779793B2
JP6779793B2 JP2016573564A JP2016573564A JP6779793B2 JP 6779793 B2 JP6779793 B2 JP 6779793B2 JP 2016573564 A JP2016573564 A JP 2016573564A JP 2016573564 A JP2016573564 A JP 2016573564A JP 6779793 B2 JP6779793 B2 JP 6779793B2
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lymphoma
pharmaceutical composition
nhl
ezh2
composition according
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JP2017518334A5 (enExample
JP2017518334A (ja
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カイルハック ハイケ
カイルハック ハイケ
オデセン ローン
オデセン ローン
レイデルマン ラリッサ
レイデルマン ラリッサ
ケー． ナットソン サラ
ケー． ナットソン サラ
エル． ジョンストン ダニエル
エル． ジョンストン ダニエル
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Eisai R&D Management Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016573564A 2014-06-17 2015-06-17 リンパ腫を治療するためのｅｚｈ２阻害剤 Active JP6779793B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462013522P 2014-06-17 2014-06-17
US62/013,522 2014-06-17
US201462036265P 2014-08-12 2014-08-12
US62/036,265 2014-08-12
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

Publications (3)

Publication Number Publication Date
JP2017518334A JP2017518334A (ja) 2017-07-06
JP2017518334A5 JP2017518334A5 (enExample) 2018-08-09
JP6779793B2 true JP6779793B2 (ja) 2020-11-04

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US (5) US10166238B2 (enExample)
EP (2) EP4252851A3 (enExample)
JP (1) JP6779793B2 (enExample)
KR (2) KR102497728B1 (enExample)
CN (2) CN106999498B (enExample)
AU (3) AU2015277139A1 (enExample)
BR (1) BR112016029492A2 (enExample)
CA (1) CA2952074C (enExample)
DK (1) DK3157527T3 (enExample)
EA (1) EA038337B1 (enExample)
ES (1) ES2948442T3 (enExample)
FI (1) FI3157527T3 (enExample)
HU (1) HUE062158T2 (enExample)
IL (3) IL309539A (enExample)
LT (1) LT3157527T (enExample)
MX (2) MX2021007651A (enExample)
PL (1) PL3157527T3 (enExample)
PT (1) PT3157527T (enExample)
SG (2) SG11201610273VA (enExample)
SI (1) SI3157527T1 (enExample)
WO (1) WO2015195848A1 (enExample)

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KR102497728B1 (ko) 2023-02-09
EP4252851A3 (en) 2023-11-22
CN106999498A (zh) 2017-08-01
MX2021007651A (es) 2021-08-11
AU2015277139A1 (en) 2016-12-22
US20200022987A1 (en) 2020-01-23
MX2016016744A (es) 2017-11-30
FI3157527T3 (fi) 2023-07-25
US20190175604A1 (en) 2019-06-13
CN106999498B (zh) 2021-06-08
IL285201B1 (en) 2024-01-01
EA201692285A1 (ru) 2017-06-30
CA2952074A1 (en) 2015-12-23
BR112016029492A2 (pt) 2017-10-17
CN113289022A (zh) 2021-08-24
AU2022263523A1 (en) 2022-12-08
EA201692285A8 (ru) 2018-01-31
EP3157527A1 (en) 2017-04-26
IL249438A0 (en) 2017-02-28
IL285201B2 (en) 2024-05-01
US11642347B2 (en) 2023-05-09
AU2020244382B2 (en) 2022-08-04
EP4252851A2 (en) 2023-10-04
EA038337B1 (ru) 2021-08-11
US20200323866A1 (en) 2020-10-15
AU2020244382A1 (en) 2020-10-29
SG11201610273VA (en) 2017-01-27
US20170216300A1 (en) 2017-08-03
NZ727108A (en) 2023-09-29
LT3157527T (lt) 2023-07-25
IL309539A (en) 2024-02-01
KR20230031963A (ko) 2023-03-07
WO2015195848A8 (en) 2016-07-07
PT3157527T (pt) 2023-06-30
JP2017518334A (ja) 2017-07-06
SI3157527T1 (sl) 2023-09-29
SG10201811128RA (en) 2019-01-30
EP3157527A4 (en) 2018-05-23
HUE062158T2 (hu) 2023-10-28
US20240058348A1 (en) 2024-02-22
US10166238B2 (en) 2019-01-01
IL285201A (en) 2021-08-31
ES2948442T3 (es) 2023-09-12
PL3157527T3 (pl) 2023-08-07
DK3157527T3 (da) 2023-07-03
WO2015195848A1 (en) 2015-12-23
KR20170052558A (ko) 2017-05-12
CA2952074C (en) 2022-08-30
EP3157527B1 (en) 2023-05-24
MX383866B (es) 2025-03-14

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