JP6767368B2 - 抗癌性組成物 - Google Patents

抗癌性組成物 Download PDF

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JP6767368B2
JP6767368B2 JP2017529637A JP2017529637A JP6767368B2 JP 6767368 B2 JP6767368 B2 JP 6767368B2 JP 2017529637 A JP2017529637 A JP 2017529637A JP 2017529637 A JP2017529637 A JP 2017529637A JP 6767368 B2 JP6767368 B2 JP 6767368B2
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arn
solid dispersion
poly
meth
acrylate copolymer
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Japanese (ja)
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JP2017536401A (ja
JP2017536401A5 (OSRAM
Inventor
ヴァーレック，ガート
Original Assignee
アラゴン ファーマシューティカルズ，インコーポレイテッド
アラゴン ファーマシューティカルズ，インコーポレイテッド
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Application filed by アラゴン ファーマシューティカルズ，インコーポレイテッド, アラゴン ファーマシューティカルズ，インコーポレイテッド filed Critical アラゴン ファーマシューティカルズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2017529637A 2014-12-05 2015-12-03 抗癌性組成物 Active JP6767368B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14196591.3 2014-12-05
EP14196591 2014-12-05
PCT/US2015/063667 WO2016090101A1 (en) 2014-12-05 2015-12-03 Anticancer compositions

Publications (3)

Publication Number Publication Date
JP2017536401A JP2017536401A (ja) 2017-12-07
JP2017536401A5 JP2017536401A5 (OSRAM) 2019-01-17
JP6767368B2 true JP6767368B2 (ja) 2020-10-14

Family

ID=52006905

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017529637A Active JP6767368B2 (ja) 2014-12-05 2015-12-03 抗癌性組成物

Country Status (31)

Country Link
US (3) US20170360707A1 (OSRAM)
EP (2) EP3842034B1 (OSRAM)
JP (1) JP6767368B2 (OSRAM)
KR (1) KR102348325B1 (OSRAM)
CN (2) CN106999430A (OSRAM)
AR (1) AR102924A1 (OSRAM)
AU (1) AU2015358493B2 (OSRAM)
CA (1) CA2969661C (OSRAM)
CL (1) CL2017001372A1 (OSRAM)
CO (1) CO2017005573A2 (OSRAM)
CR (1) CR20170217A (OSRAM)
CY (1) CY1123856T1 (OSRAM)
DK (1) DK3226842T3 (OSRAM)
EA (1) EA035988B1 (OSRAM)
ES (2) ES2839128T3 (OSRAM)
HR (1) HRP20201902T1 (OSRAM)
HU (1) HUE051888T2 (OSRAM)
IL (1) IL252324B (OSRAM)
LT (1) LT3226842T (OSRAM)
MA (2) MA55404A (OSRAM)
MD (1) MD3226842T2 (OSRAM)
MX (1) MX384382B (OSRAM)
NI (1) NI201700069A (OSRAM)
PL (1) PL3226842T3 (OSRAM)
PT (1) PT3226842T (OSRAM)
RS (1) RS61466B1 (OSRAM)
SG (1) SG11201704264UA (OSRAM)
SI (1) SI3226842T1 (OSRAM)
TW (1) TWI683662B (OSRAM)
UA (1) UA121123C2 (OSRAM)
WO (1) WO2016090101A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2836424T3 (es) 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
RS66323B1 (sr) 2014-12-05 2025-01-31 Aragon Pharmaceuticals Inc Sastavi protiv raka
MA41111B1 (fr) 2014-12-05 2021-09-30 Aragon Pharmaceuticals Inc Compositions anticancéreuses
UA129105C2 (uk) 2017-10-16 2025-01-15 Арагон Фармасьютикалз, Інк. Антиандрогени для лікування неметастатичного резистентного до кастрації раку передміхурової залози
ES2967689T3 (es) * 2018-04-06 2024-05-03 Capsugel Belgium Nv Proceso de secado por aspersión para partículas de baja relación de aspecto que comprenden poli[(metacrilato de metilo)-co-(ácido metacrílico)]
WO2020144647A1 (en) 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Pharmaceutical composition comprising apalutamide dispersed in apple sauce
JP2022523094A (ja) 2019-01-30 2022-04-21 アラゴン ファーマシューティカルズ，インコーポレイテッド 転移性去勢感受性前立腺癌の治療のための抗アンドロゲン剤
US20210115517A1 (en) 2019-01-30 2021-04-22 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CA3160121A1 (en) 2019-11-04 2021-05-14 Aragon Pharmaceuticals, Inc. Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment
WO2021245285A1 (en) 2020-06-05 2021-12-09 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
TW202228794A (zh) 2020-09-04 2022-08-01 美商艾瑞岡醫藥公司 用於治療前列腺癌之方法
WO2022195407A1 (en) 2021-03-19 2022-09-22 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2023152611A1 (en) 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer
WO2023209555A1 (en) 2022-04-26 2023-11-02 Aragon Pharmaceuticals, Inc. Approved drug products and methods for treating prostate cancer
AU2024236119A1 (en) 2023-03-16 2025-09-25 Bayer Consumer Care Ag Androgen receptor antagonists for the treatment of patients with biochemical recurrence of hormone sensitive prostate cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080902A1 (en) 2001-04-02 2002-10-17 Astrazeneca Ab Solid pharmaceutical composition comprising 4 -cyano-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono- m toluidide and pvp
WO2003077827A1 (en) * 2002-03-19 2003-09-25 Nippon Shinyaku Co., Ltd. Process for producing drug solid dispersion
EP1694302A1 (en) * 2003-12-15 2006-08-30 Council of Scientific and Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
EP4385574A3 (en) * 2006-03-27 2024-10-02 The Regents of the University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
KR101819199B1 (ko) * 2010-02-16 2018-01-16 아라곤 파마슈티컬스, 인코포레이티드 안드로겐 수용체 조절제 및 이의 용도
EP2721003B1 (en) * 2011-06-15 2018-01-03 The United States of America, as Represented by The Secretary, Department of Health and Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer
WO2013152342A1 (en) * 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
CN113135892A (zh) 2012-06-07 2021-07-20 阿拉贡药品公司 雄激素受体调节剂的晶形
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
EA033374B9 (ru) * 2012-09-11 2019-12-18 Медивейшн Простейт Терапьютикс Ллк Твердые фармацевтические композиции, содержащие энзалутамид, и способ лечения
ES2836424T3 (es) * 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
JOP20200097A1 (ar) * 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
AU2014210103B2 (en) * 2013-01-22 2018-09-06 F. Hoffmann-La Roche Ag Pharmaceutical composition with improved bioavailability
WO2014167428A2 (en) 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
SG11201600525XA (en) * 2013-08-12 2016-02-26 Tokai Pharmaceuticals Inc Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CN112402360A (zh) * 2014-02-05 2021-02-26 斯洛文尼亚莱柯制药股份有限公司 雄激素受体拮抗剂的固体药物组合物

Also Published As

Publication number Publication date
US20170360707A1 (en) 2017-12-21
EP3842034A1 (en) 2021-06-30
SI3226842T1 (sl) 2021-04-30
MX2017007201A (es) 2018-01-30
IL252324B (en) 2021-10-31
AU2015358493A1 (en) 2017-06-08
JP2017536401A (ja) 2017-12-07
MA41108B1 (fr) 2021-03-31
EP3842034B1 (en) 2025-02-12
AU2015358493B2 (en) 2021-05-06
EP3226842B1 (en) 2020-11-25
CL2017001372A1 (es) 2018-01-05
MA41108A (fr) 2016-06-09
HUE051888T2 (hu) 2021-03-29
KR102348325B1 (ko) 2022-01-06
KR20170086657A (ko) 2017-07-26
LT3226842T (lt) 2021-03-25
CN115837010B (zh) 2025-03-14
NI201700069A (es) 2017-10-31
US20220151931A1 (en) 2022-05-19
EA035988B1 (ru) 2020-09-09
CO2017005573A2 (es) 2017-09-29
MX384382B (es) 2025-03-14
IL252324A0 (en) 2017-07-31
TW201632187A (zh) 2016-09-16
BR112017011787A2 (pt) 2017-12-26
PT3226842T (pt) 2020-12-23
EA201791252A1 (ru) 2017-10-31
CN106999430A (zh) 2017-08-01
CY1123856T1 (el) 2022-05-27
US20240293321A1 (en) 2024-09-05
CA2969661C (en) 2023-04-25
HRP20201902T1 (hr) 2021-07-23
DK3226842T3 (da) 2021-01-25
MD3226842T2 (ro) 2021-03-31
PL3226842T3 (pl) 2021-07-12
UA121123C2 (uk) 2020-04-10
AR102924A1 (es) 2017-04-05
CN115837010A (zh) 2023-03-24
ES2839128T3 (es) 2021-07-05
ES3021508T3 (en) 2025-05-27
RS61466B1 (sr) 2021-03-31
MA55404A (fr) 2022-02-02
SG11201704264UA (en) 2017-06-29
TWI683662B (zh) 2020-02-01
CR20170217A (es) 2017-08-30
EP3226842A1 (en) 2017-10-11
CA2969661A1 (en) 2016-06-09
WO2016090101A1 (en) 2016-06-09

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