JP6758955B2 - Oral paste-like composition - Google Patents

Description

The present invention relates to an oral paste-like composition.

Periodontal disease is an inflammatory disease that develops when periodontal pathogens settle in the oral cavity, and is roughly classified into periodontitis and periodontitis. Insufficient oral cleaning causes plaque (oral bacteria and their metabolites) to adhere to the boundary between the gums and teeth, then settle and proliferate. Neutrophils and macrophages infiltrate in response to this foreign substance, causing inflammation. This is a condition called periodontitis, which mainly presents with symptoms such as redness and swelling of the gums and bleeding during brushing. At this stage, removing the plaque by cleaning the mouth, such as by brushing or using floss, will improve the inflammation of the gums.

However, if the plaque is left as it is accumulated, the inflammation further spreads and progresses to periodontal pocket formation and alveolar bone resorption due to destruction of the periodontal ligament. When a periodontal pocket is formed, the plaque accumulated in the pocket is difficult to remove by self-care such as brushing, so that the condition becomes worse. Once destroyed, the periodontal ligament and resorbed alveolar bone cannot be restored. Periodontitis is a condition accompanied by such destruction of periodontal tissue. In this state, redness / swelling of the gums and bleeding occur chronically, bad breath becomes severe, and the periodontium is destroyed, so that the teeth begin to shake and pus leaks from the inflamed area.

Periodontal disease, if left in an inflamed state for a long time, progresses and leads to irreversible destruction of periodontal tissue. Therefore, in daily self-care, anti-inflammatory is applied to the gingiva that has symptoms. It is important to use a symptomatic agent such as an agent or a hemostatic agent and a preparation containing a bactericidal agent that suppresses the deposition of plaque in order to prevent the progression and worsening of periodontal disease.

As a bactericide that suppresses the deposition of dental plaque, cetylpyridinium chloride (CPC), chlorhexidine hydrochloride and the like have been used as over-the-counter periodontal disease agents (alveolar pyorrhea agents). However, although chlorhexidines have a high effect of suppressing plaque deposition, they have a problem that they may cause anaphylactic shock when applied to mucous membranes.

Cetylpyridinium chloride is a combination that has been conventionally accepted in order to obtain a plaque-forming inhibitory effect equal to or higher than 0.1% chlorhexidine hydrochloride, which is a precedent for the combination of over-the-counter periodontal disease drugs (pyorrhea). It is necessary to formulate at a concentration higher than the concentration (0.05%) (for example, 0.1% to 0.5%). In addition, since cetylpyridinium chloride is a substance that exhibits bitterness and irritation, it is required to add a fragrance when it is used in a high concentration. As an oral composition that meets such a demand, for example, an oral composition that reduces irritation and contains a high concentration of cetylpyridinium chloride has been reported (Patent Document 1).

JP-A-2010-280610

The present inventors have conducted various studies in advancing the commercialization of an oral paste-like composition containing cetylpyridinium chloride, and surprisingly, the concentration is as high as 0.1 to 0.5% by mass. When a paste-like composition uniformly containing cetylpyridinium chloride is filled in a container and stored at a low temperature (5 ° C.) for 6 months, the concentration of cetylpyridinium chloride in the paste-like composition becomes non-uniform (chloride). Cetylpyridinium is localized). It has long been known that the problem does not occur in the paste-like composition containing 0.05% by mass of cetylpyridinium chloride, which is a conventional embodiment. (See the reference test example below).

The present invention has been made in view of the above-mentioned problems, and localization of cetylpyridinium chloride is performed in a paste-like composition containing a high concentration (0.1 to 0.5% by mass) of cetylpyridinium chloride. It is an object of the present invention to provide a significantly reduced paste-like composition.

As a result of intensive studies to achieve the above object, the present inventors have found that a paste-like composition containing a high concentration (0.1 to 0.5% by mass) of cetylpyridinium chloride has 2 to 4 carbon atoms. It has been found that the localization of cetylpyridinium chloride in the paste-like composition can be significantly reduced by blending a specific amount of the monohydric or divalent alcohol and glycerin. Further, it was confirmed that the paste-like composition is excellent in usability (spinning property, burning sensation, shape retention, etc.) required as an oral paste-like composition. Based on such findings, the present inventors have completed the present invention by repeating further research.

That is, the present invention includes the oral paste-like composition described in the following section.
Item 1.
(A) Cetylpyridinium chloride 0.1-0.5% by mass,
(B) 15 to 35% by mass of monohydric or divalent alcohol having 2 to 4 carbon atoms.
An oral paste containing 5 to 40% by mass of (C) glycerin and (D) a binder, and the total amount of the components (B) and (C) is 40 to 55% by mass. State composition.
Item 2.
Item 2. The composition according to Item 1, wherein the amount of the component (B) is 15 to 30% by mass.
Item 3.
Item 2. The composition according to Item 1 or 2, wherein the blending amount of the component (C) is 10 to 40% by mass.
Item 4.
Item 2. The composition according to any one of Items 1 to 3, wherein the component (B) is at least one selected from the group consisting of ethanol, propylene glycol, and 1,3-butylene glycol.

According to the present invention, cetylpyridinium chloride is excellent in usability required as an oral paste-like composition having appropriate spinnability, reduced burning sensation, and good shape retention. It is possible to provide a paste-like composition in which localization is significantly suppressed.

It is a figure which shows the result of the reference test example (reference example 1). It is a figure which shows the result of the reference test example (reference example 2). It is a schematic diagram which shows the experimental operation of Test Example 1-1.

Hereinafter, the present invention will be described in detail.

The oral paste-like composition of the present invention contains (A) cetylpyridinium chloride in an amount of 0.1 to 0.5% by mass and (B) a monohydric or divalent alcohol having 2 to 4 carbon atoms in an amount of 15 to 35% by mass. , (C) glycerin in an amount of 5-40% by mass, and (D) a binder. In this specification, the components (A) to (D) are described as "(A) component", "(B) component", "(C) component", and "(D) component", respectively. May be done.

Further, the oral paste-like composition of the present invention satisfies the condition that the total amount of the component (B) and the component (C) is 40 to 55% by mass in addition to the above conditions.

By satisfying all of the above conditions, it has a good usability required as an oral paste-like composition, which has an appropriate spinnability, a reduced burning sensation, and a good shape retention. However, it is possible to obtain a paste-like composition in which the localization of cetylpyridinium chloride is significantly suppressed.

Cetylpyridinium chloride (which may be referred to as "CPC" in the present specification) as a component (A) is a cationic bactericidal component classified as a quaternary ammonium compound, and is used in the field of oral compositions. Widely used. The blending amount of the component (A) in the oral paste-like composition of the present invention is 0.1 to 0.5% by mass, preferably 0.1 to 1% by mass, based on the total amount of the oral paste-like composition of the present invention. 0.45% by mass, more preferably 0.1 to 0.4% by mass, still more preferably 0.1 to 0.35% by mass, even more preferably 0.1 to 0.3% by mass, particularly preferably. It is 0.15 to 0.3% by mass. Conventionally, the amount of cetylpyridinium chloride used in oral compositions sold on the market including pharmaceuticals is 0.05% by mass or less. On the other hand, since the oral paste-like composition of the present invention contains cetylpyridinium chloride in an amount of 0.1 to 0.5% by mass, a higher concentration of cetylpyridinium chloride can be obtained as compared with the conventional oral composition. It can be said that it is mixed. In the present specification, the case where the blending amount of cetylpyridinium chloride is 0.1 to 0.5% by mass is "high concentration" in the sense of distinguishing it from the blending amount of cetylpyridinium chloride in the conventional oral composition. It may be expressed as.

The monohydric or divalent alcohol having 2 to 4 carbon atoms as the component (B) is not particularly limited as long as it can be blended in the oral composition, and known ones can be used. Examples thereof include ethanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 2,3-butylene glycol and the like, among which ethanol, propylene glycol and 1,3-butylene. Glycol is preferred, and propylene glycol is particularly preferred. As the component (B), one type may be used alone, or two or more types may be used in combination.

The blending amount of the component (B) in the oral paste-like composition of the present invention is 15 to 35% by mass, preferably 15 to 30% by mass, more preferably 15 to 30% by mass, based on the total amount of the oral paste-like composition of the present invention. Is 15 to 25% by mass, more preferably 17.5 to 22.5% by mass, even more preferably 18 to 22% by mass, and particularly preferably 19 to 21% by mass.

The blending amount of glycerin, which is the component (C), in the oral paste-like composition of the present invention is 5 to 40% by mass, preferably 10 to 40% by mass, based on the total amount of the oral paste-like composition of the present invention. , More preferably 15 to 40% by mass, still more preferably 20 to 40% by mass, even more preferably 25 to 40% by mass, and particularly preferably 25 to 35% by mass.

The binder as the component (D) is not particularly limited as long as it can be blended in the oral composition and the form of the composition can be made into a paste, and known ones are used. can do. For example, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, crystalline cellulose, crystalline cellulose / carmellose sodium, O- [2-hydroxy-3- (trimethylammonio) chloride. ) Cellulose derivatives such as hydroxyethyl cellulose; alkali metal salts of alginic acid such as sodium alginate; microbially produced polymers such as xanthan gum and gellan gum; tragant gum, karaya gum, and arabic gum. Natural polymers such as carrageenan, dextrin, agar, pectin, purulan, locust bean gum; synthetic polymers such as polyvinyl alcohol, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyvinylmethyl ether, sodium polyacrylate, bee gum, etc. Can be mentioned. The component (D) may be used alone or in combination of two or more.

The blending amount of the component (D) in the oral paste-like composition of the present invention is not particularly limited as long as it can be used as a paste-like composition, and is appropriately determined according to the type of binder used. be able to. For example, when hydroxyethyl cellulose is used as the component (D), the blending amount of the component (D) is 0.05 to 5% by mass, preferably 0.1, based on the total amount of the oral paste-like composition of the present invention. ~ 3% by mass, more preferably 0.5 to 2% by mass, still more preferably 1-2% by mass, even more preferably 1.2 to 1.8% by mass, particularly preferably 1.4 to 1.6. It is mass%.

The total amount of the component (B) and the component (C) in the oral paste-like composition of the present invention is 40 to 55% by mass, preferably 42, based on the total amount of the oral paste-like composition of the present invention. It is .5-55% by mass, more preferably 45-55% by mass, still more preferably 47.5-55% by mass, and particularly preferably 47.5-52.5% by mass.

The oral paste-like composition of the present invention takes a paste-like form by containing the component (D). In the present specification, there is a clear distinction between paste and liquid or gel.

In addition to the above-mentioned components (A) to (D), the oral paste-like composition of the present invention contains, if necessary, components that can be blended into the oral composition as long as the effects of the present invention are not impaired. Can be blended. For example, medicinal ingredients other than the component (A), surfactants, sweeteners, flavoring agents, abrasives, excipients, wetting agents, preservatives, coloring agents, pH adjusters and the like can be mentioned.

Examples of the medicinal ingredient other than the component (A) include cationic bactericides such as benzalkonium chloride, benzethonium chloride and chlorhexidine hydrochloride; amphoteric bactericides such as dodecyldiaminoethylglycine; nonionic sterilization such as triclosan and isopropylmethylphenol. Agents: Anti-inflammatory agents such as glycyrrhizinates such as glycyrrhetinic acid and dipotassium glycyrrhizinate; Vitamin Es such as dl-α-tocopherol acetate, tocopherol succinate, tocopherol nicotinate; , Enzymes such as lytic enzyme (Litec Enzyme); Hemorrhage improvers such as ascorbic acid, tranexamic acid, epsilon aminocaproic acid, carbazochrome, aluminum chlorhexyl allantoin, sodium chloride; Alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, fluorine compounds such as stannous fluoride, as well as dihydrocholesterol, glycerophosphate, chlorophyll, caropeptide, hinokithiol, potassium nitrate, palatinite, etc. Can be mentioned. The medicinal ingredient other than the ingredient (A) may be used alone or in combination of two or more. Further, the blending amount of the medicinal ingredient other than the ingredient (A) in the oral paste-like composition of the present invention is not particularly limited, and can be appropriately determined according to the type of the medicinal ingredient to be used and the like.

Examples of the surfactant include a nonionic surfactant, an anionic surfactant, and an amphoteric surfactant. More specifically, examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, and lactose fatty acid ester, fatty acid alkanolamides, sorbitan fatty acid esters, fatty acid monoglyceride, and polyoxyethylene addition coefficient. Is a polyoxyethylene alkyl ether system having 4 to 15 and an alkyl group having 10 to 18 carbon atoms, a polyoxyethylene alkylphenyl ether having a polyoxyethylene addition coefficient of 10 to 18 and an alkyl group having 9 carbon atoms, and sebacin. Diethyl acid acid, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyethylene lanolin, polyethylene sterol, polyethylene lanolin alcohol, alkyl glucoside, poly Examples thereof include oxyethylene polyoxypropylene block copolymers. Examples of the anionic surfactant include sulfate ester salts such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate, sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate, sodium cocoyl sarcosin, and lauroyl. Examples thereof include acyl amino acid salts such as sodium methylalanine and sodium cocoyl methyl taurine. Examples of the amphoteric ion surfactant include betaine acetate-type surfactants such as lauryldimethylaminoacetate betaine and coconut oil fatty acid amidopropyldimethylaminoacetate betaine, and N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium. Examples thereof include imidazoline type activators and amino acid type activators such as N-lauryldiaminoethylglycine. The surfactant may be used alone or in combination of two or more. Further, the blending amount of the surfactant in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.001 to 0.001 to the total amount of the oral paste-like composition of the present invention. It can be 5% by mass.

Sweeteners include saccharin, sodium saccharin, acesulfarm potassium, stevia extract, stebioside, neohesperidyldihydrochalcone, glycyrrhizin, perillartine, soumatin, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, maltitol. , Xylitol, lactitol and the like. The sweetener may be used alone or in combination of two or more. Further, the blending amount of the sweetener in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.001 to 10 based on the total amount of the oral paste-like composition of the present invention. It can be% by mass.

Examples of flavoring agents include menthol, carboxylic acid, anetol, eugenol, methyl salicylate, limonene, osimene, n-decyl alcohol, citronel, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool. , Ethyl linalool, Timor, Sparemint oil, Peppermint oil, Lemon oil, Orange oil, Sage oil, Rosemary oil, Silica skin oil, Perilla oil, Winter green oil, Chome oil, Eucalyptus oil, Pimento oil, d-campul, d -Bornool, orange oil, kehi oil, limonene aldehyde, peppermint oil, vanillin and the like. The flavoring agent may be used alone or in combination of two or more. Further, the blending amount of the flavoring agent in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.001 to 5 based on the total amount of the oral paste-like composition of the present invention. It can be% by mass.

Examples of the polishing agent include abrasive silica such as abrasive precipitated silica and abrasive gel silica, calcium hydrogen phosphate / dihydrate and anhydride, calcium phosphate, calcium tertiary phosphate, magnesium tertiary phosphate, calcium pyrophosphate, and hydroxy. Apatite, insoluble sodium metaphosphate, aluminum silicate, zirconium silicate, calcium silicate, calcium carbonate, magnesium carbonate, alumina, aluminum hydroxide, calcium sulfate, polymethylmethacrylate, pamisu (pallet stone), bentonite, synthetic resin, etc. Can be mentioned. One type of abrasive may be used alone, or two or more types may be used in combination. The amount of the abrasive in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 1 to 40% by mass is based on the total amount of the oral paste-like composition of the present invention. Can be.

Examples of excipients include lactose, sucrose, mannitol, starch, dextrin, calcium hydrogen phosphate, calcium carbonate, light anhydrous silicic acid and the like. The excipient may be used alone or in combination of two or more. The amount of the excipient in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 1 to 40 mass by mass based on the total amount of the oral paste-like composition of the present invention. Can be%.

Examples of the wetting agent and the hydrotrope agent include dipropylene glycol, isoprene glycol, glycerin, sorbitol, polyethylene glycol, polypropylene glycol and the like. The wetting agent may be used alone or in combination of two or more. Further, the blending amount of the wetting agent in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.01 to 40 based on the total amount of the oral paste-like composition of the present invention. It can be% by mass.

Examples of the preservative include parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like. The preservative may be used alone or in combination of two or more. Further, the blending amount of the preservative in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.001 to 5 based on the total amount of the oral paste-like composition of the present invention. It can be% by mass.

Examples of the colorant include legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine blue, enhanced ultramarine blue, and dark blue, titanium oxide, and the like. The colorant may be used alone or in combination of two or more. Further, the blending amount of the colorant in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined. For example, 0.00001 to 5 is based on the total amount of the oral paste-like composition of the present invention. It can be% by mass.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphate, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, chemically possible salts thereof, sodium hydroxide and the like. The pH adjuster may be used alone or in combination of two or more. Further, the blending amount of the pH adjuster in the oral paste-like composition of the present invention is not particularly limited and can be appropriately determined.

The oral paste-like composition of the present invention can be produced by a conventional method. For example, it can be produced by mixing the above-mentioned components (A) to (D) and, if necessary, any component.

The dosage form of the oral paste-like composition of the present invention is not particularly limited as long as it is in the form of a paste, and may be in the form of, for example, a paste, a dentifrice, an ointment, a cream, a pasta, or the like. ..

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

Reference Test Example The paste-like compositions of Reference Examples 1 and 2 were prepared by blending each component shown in Table 1 below at the ratio (mass%) shown in Table 1 below.

Next, 25 g of each paste-like composition was filled in a 22 mm diameter aluminum laminated tube (body diameter: 22 mm) having a shoulder portion made of high density polyethylene (HDPE), and stored at 5 ° C. for 6 months. After 6 months, each paste-like composition was squeezed linearly from the laminate tube toward the right end of the glass plate starting from the left end of the glass plate. The left end of the paste-like composition squeezed out on the glass plate is described as the tip, and the right end is described as the end. Then, 1 g of each paste-like composition squeezed out was separated from the tip to the end, and cetylpyridinium chloride was quantified by liquid chromatography. Then, the amount of cetylpyridinium chloride in each sample collected based on the blending amount of cetylpyridinium chloride at the time of preparation of each paste-like composition was analyzed. The results are shown in FIG.

As is clear from FIG. 1, in the paste-like composition of Reference Example 1, it was confirmed that the concentration of cetylpyridinium chloride near the tip was high and the concentration of cetylpyridinium chloride near the end was low. On the other hand, in the paste-like composition of Reference Example 2, unlike in Reference Example 1, it was confirmed that the concentration of cetylpyridinium chloride was substantially constant from the tip to the end. From the above, when a paste-like composition containing a high concentration of cetylpyridinium chloride is stored at a low temperature (5 ° C.) for 6 months, the concentration of cetylpyridinium chloride in the paste-like composition becomes non-uniform ( It was found that such a problem does not occur in the paste-like composition containing 0.05% by mass of cetylpyridinium chloride, whereas cetylpyridinium chloride is localized). That is, it was found that the localization of cetylpyridinium chloride in the paste-like composition is a problem confirmed only when a high concentration of cetylpyridinium chloride is contained.

Manufacturing example 1
The paste-like compositions of Examples 1 to 19 and Comparative Examples 1 to 40 were prepared by blending each component shown in Table 2 below at the ratio (mass%) shown in Table 2 below.

Test Example 1
Next, each of the paste-like compositions prepared in the above production examples was subjected to the following tests of Test Examples 1 to 4.

Test Example 1-1: Uniformity Confirmation Test of Cetylpyridinium Chloride In the same manner as in the above Reference Test Example, 25 g of each paste-like composition prepared in Production Example 1 is aluminum having a shoulder made of high-density polyethylene (HDPE). It was filled in a laminated tube (body diameter: 22 mm) and stored at 5 ° C. for 6 months. After 6 months, each paste-like composition was squeezed linearly from the laminate tube toward the right end of the glass plate starting from the left end of the glass plate. The left end of the paste-like composition squeezed out on the glass plate is described as the tip, and the right end is described as the end. Then, as shown in FIG. 2, a total of 9 samples of each squeezed paste-like composition, 1 g each at 3 points from the tip, 1 g each at 3 points from the middle portion, and 1 g each at 3 points from the end, were sampled and liquid was collected. Cetylpyridinium chloride was quantified by chromatography. Then, the relative standard deviation (CV value) of the measured value of cetylpyridinium chloride was calculated by the following formula.

Further, the CV value calculated above was evaluated for the uniformity of the paste-like composition based on the following evaluation criteria.

<Evaluation criteria>
◯: CV value is 1.5% or less Δ: CV value is more than 1.5% and 3.0% or less ×: CV value is more than 3.0%

The results of Test Example 1-1 above are shown in the “Uniformity (Test Example 1-1)” column of Table 2 below. In the same column, the symbol representing the evaluation result is described in the upper row, and the CV value is described in the lower row.

Test Example 1-2: Spinning property confirmation test 100 g of each paste-like composition prepared in Production Example 1 above is weighed in a beaker, heated to 30 ° C., and then a stainless steel ball having a diameter of 16 mm is placed in the beaker. After pushing the composition to a position of 8 mm from the upper surface, the stainless ball was raised at a speed of 1000 mm / min until the string of the paste-like composition attached to the stainless ball was cut. Then, the height (mm) of the stainless steel ball when the thread was broken was measured from the upper surface of the paste-like composition in the beaker.

Furthermore, the spinnability of the paste-like composition was evaluated based on the following evaluation criteria based on the measured values measured above.

<Evaluation criteria>
◯: less than 5 mm ×: 5 mm or more

The results of the above Test Examples 1-2 are shown in the “Spinning property (Test Example 1-2)” column of Table 2 below. In the same column, the symbol indicating the evaluation result is described in the upper row, and the measured value is described in the lower row.

Test Example 1-3: Confirmation test of burning sensation About 0.5 g of each paste-like composition prepared in Production Example 1 above was taken with a toothbrush, and five specialized panelists brushed their teeth based on the following evaluation criteria. I was asked to evaluate the burning sensation. After that, the one with the most evaluation was adopted as a result.

<Evaluation criteria>
-: The burning sensation is hardly felt or bothered. +: The burning sensation is strongly felt.

The results of Test Examples 1-3 above are shown in the “Burning sensation (Test Examples 1-3)” column of Table 2 below.

Test Example 1-4: Shape retention confirmation test For each paste-like composition prepared in Production Example 1 above, a helipas-type viscometer (manufactured by Eiko Seiki Co., Ltd., trade name: DV-I Prime) Spindle No. Using 95, the viscosity was measured under the conditions of 30 ° C., 10 rpm, and 60 seconds later. Then, the shape retention of each paste-like composition was evaluated based on the following evaluation criteria.

<Evaluation criteria>
◯: 50,000 mPa · s or more (with shape retention)
×: Less than 50,000 mPa · s (no shape retention)

The results of Test Examples 1-4 above are shown in the "Retainability (Test Examples 1-4)" column of Table 2 below.

From the results of Test Example 1 above, in the paste-like composition containing a high concentration of cetylpyridinium chloride, the components (1) and (B) are 15 to 35% by mass, and the components (2) and (C) are 5 to 40% by mass. Only when all the conditions that the total amount of the components (3), (B) and (C) is 40 to 55% by mass are satisfied, the material has an appropriate spinnability and is burning. It is possible to obtain a paste-like composition having an excellent feeling of use as an oral paste-like composition having a reduced feeling and good shape-retaining property, and having suppressed localization of cetylpyridinium chloride. I found out.

Claims (5)

(A) Cetylpyridinium chloride 0.1 to 0.3 % by mass,
(B) 15 to 35% by mass of monohydric or divalent alcohol having 2 to 4 carbon atoms.
An oral paste containing 5 to 40% by mass of (C) glycerin and (D) a binder, and the total amount of the (B) component and the (C) component is 40 to 55% by mass. State composition (excluding the oral paste-like composition containing azulene and the oral paste-like composition containing benzidamine or a salt thereof). The composition according to claim 1, wherein the blending amount of the component (B) is 15 to 30% by mass. The composition according to claim 1 or 2, wherein the blending amount of the component (C) is 10 to 40% by mass. The composition according to any one of claims 1 to 3, wherein the component (B) is at least one selected from the group consisting of ethanol, propylene glycol, and 1,3-butylene glycol. The component (D) is hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, crystalline cellulose, crystalline cellulose / carmellose sodium, O- [2-hydroxy-3 chloride. -(Trimethylammonio) propyl] hydroxyethyl cellulose, sodium alginate, xanthan gum, gellan gum, tragant gum, karaya gum, arabic gum, carrageenan, dextrin, agar, pectin, purulan, locust bean gum, polyvinyl alcohol, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl The composition according to any one of claims 1 to 4, which is at least one selected from the group consisting of a polymer, polyvinyl methyl ether, sodium polyacrylate, and bee gum.