JP6755859B2 - アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法 - Google Patents

アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法 Download PDF

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JP6755859B2
JP6755859B2 JP2017518431A JP2017518431A JP6755859B2 JP 6755859 B2 JP6755859 B2 JP 6755859B2 JP 2017518431 A JP2017518431 A JP 2017518431A JP 2017518431 A JP2017518431 A JP 2017518431A JP 6755859 B2 JP6755859 B2 JP 6755859B2
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solvent
substituted
alkyl
alkene
certain embodiments
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JP2017532329A (ja
JP2017532329A5 (enExample
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ディー バーク，マーティン
ディー バーク，マーティン
イー ウノ，ブライス
イー ウノ，ブライス
ラクシット，ソウヴィク
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University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2017518431A 2014-10-17 2015-10-16 アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法 Active JP6755859B2 (ja)

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US201462065330P 2014-10-17 2014-10-17
US62/065,330 2014-10-17
PCT/US2015/055899 WO2016061437A1 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b

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JP2017532329A JP2017532329A (ja) 2017-11-02
JP2017532329A5 JP2017532329A5 (enExample) 2018-11-22
JP6755859B2 true JP6755859B2 (ja) 2020-09-16

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US (2) US10087206B2 (enExample)
EP (1) EP3206695A4 (enExample)
JP (1) JP6755859B2 (enExample)
AU (2) AU2015331904B2 (enExample)
WO (1) WO2016061437A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9738677B2 (en) * 2014-05-16 2017-08-22 The Board Of Trustees Of The University Of Illinois Amphotericin B derivative with reduced toxicity
AU2015331904B2 (en) * 2014-10-17 2021-02-11 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
US20230000891A1 (en) * 2019-08-08 2023-01-05 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1008720A (en) 1910-11-14 1911-11-14 John Knape Adjustable bracket.
EP0431874A1 (en) 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
EP2371815A1 (en) * 2003-12-30 2011-10-05 XenoPort, Inc. Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2014059436A1 (en) * 2012-10-12 2014-04-17 The Board Of Trustees Of The University Of Illinois Electronic tuning of site selectivity
WO2014165676A1 (en) * 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
US9738677B2 (en) * 2014-05-16 2017-08-22 The Board Of Trustees Of The University Of Illinois Amphotericin B derivative with reduced toxicity
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
AU2015331904B2 (en) * 2014-10-17 2021-02-11 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B

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US10087206B2 (en) 2018-10-02
US10683318B2 (en) 2020-06-16
US20190127412A1 (en) 2019-05-02
AU2015331904A1 (en) 2017-05-25
EP3206695A4 (en) 2018-06-20
JP2017532329A (ja) 2017-11-02
US20170233427A1 (en) 2017-08-17
AU2021202949A1 (en) 2021-06-03
AU2015331904B2 (en) 2021-02-11
WO2016061437A1 (en) 2016-04-21
AU2021202949B2 (en) 2023-07-13
EP3206695A1 (en) 2017-08-23

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