AU2015331904B2 - Scalable synthesis of reduced toxicity derivative of amphotericin B - Google Patents

Scalable synthesis of reduced toxicity derivative of amphotericin B Download PDF

Info

Publication number
AU2015331904B2
AU2015331904B2 AU2015331904A AU2015331904A AU2015331904B2 AU 2015331904 B2 AU2015331904 B2 AU 2015331904B2 AU 2015331904 A AU2015331904 A AU 2015331904A AU 2015331904 A AU2015331904 A AU 2015331904A AU 2015331904 B2 AU2015331904 B2 AU 2015331904B2
Authority
AU
Australia
Prior art keywords
certain embodiments
solvent
alkyl
alken
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015331904A
Other languages
English (en)
Other versions
AU2015331904A1 (en
Inventor
Martin D. Burke
Souvik RAKSHIT
Brice E. Uno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Publication of AU2015331904A1 publication Critical patent/AU2015331904A1/en
Application granted granted Critical
Publication of AU2015331904B2 publication Critical patent/AU2015331904B2/en
Priority to AU2021202949A priority Critical patent/AU2021202949B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015331904A 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin B Active AU2015331904B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202949A AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462065330P 2014-10-17 2014-10-17
US62/065,330 2014-10-17
PCT/US2015/055899 WO2016061437A1 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin b

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021202949A Division AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Publications (2)

Publication Number Publication Date
AU2015331904A1 AU2015331904A1 (en) 2017-05-25
AU2015331904B2 true AU2015331904B2 (en) 2021-02-11

Family

ID=55747385

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015331904A Active AU2015331904B2 (en) 2014-10-17 2015-10-16 Scalable synthesis of reduced toxicity derivative of amphotericin B
AU2021202949A Active AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021202949A Active AU2021202949B2 (en) 2014-10-17 2021-05-10 Scalable synthesis of reduced toxicity derivative of amphotericin B

Country Status (5)

Country Link
US (2) US10087206B2 (enExample)
EP (1) EP3206695A4 (enExample)
JP (1) JP6755859B2 (enExample)
AU (2) AU2015331904B2 (enExample)
WO (1) WO2016061437A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9738677B2 (en) * 2014-05-16 2017-08-22 The Board Of Trustees Of The University Of Illinois Amphotericin B derivative with reduced toxicity
AU2015331904B2 (en) * 2014-10-17 2021-02-11 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
EP3283171B1 (en) 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
US20230000891A1 (en) * 2019-08-08 2023-01-05 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284736B1 (en) * 1989-12-08 2001-09-04 Beecham Group, Plc Amphotericin derivatives
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1008720A (en) 1910-11-14 1911-11-14 John Knape Adjustable bracket.
EP2371815A1 (en) * 2003-12-30 2011-10-05 XenoPort, Inc. Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2014059436A1 (en) * 2012-10-12 2014-04-17 The Board Of Trustees Of The University Of Illinois Electronic tuning of site selectivity
WO2014165676A1 (en) * 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
AU2015331904B2 (en) * 2014-10-17 2021-02-11 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284736B1 (en) * 1989-12-08 2001-09-04 Beecham Group, Plc Amphotericin derivatives
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MITCHELL P. CROATT ET AL, "Probing the Role of the Mycosamine C2'-OH on the Activity of Amphotericin B", ORGANIC LETTERS, (2011-03-18), vol. 13, no. 6, doi:10.1021/ol2000765, ISSN 1523-7060, pages 1390 - 1393 *
PALACIOS et al., "A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation is Not Required for Potent Antifungal Activity", J Am Chem Soc., (2007), vol. 129, no. 45, pages 13804 - 13805. *
WILCOCK et al., "Electronic tuning of site-selectivity", NATURE CHEMISTRY, (2012), vol. 4, pages 996 - 1003. *

Also Published As

Publication number Publication date
US10087206B2 (en) 2018-10-02
US10683318B2 (en) 2020-06-16
US20190127412A1 (en) 2019-05-02
AU2015331904A1 (en) 2017-05-25
EP3206695A4 (en) 2018-06-20
JP2017532329A (ja) 2017-11-02
JP6755859B2 (ja) 2020-09-16
US20170233427A1 (en) 2017-08-17
AU2021202949A1 (en) 2021-06-03
WO2016061437A1 (en) 2016-04-21
AU2021202949B2 (en) 2023-07-13
EP3206695A1 (en) 2017-08-23

Similar Documents

Publication Publication Date Title
AU2021202949B2 (en) Scalable synthesis of reduced toxicity derivative of amphotericin B
AU2020281043C1 (en) Macrolides and methods of their preparation and use
AU2022201660A1 (en) Neuroactive steroids, compositions, and uses thereof
CA2956465A1 (en) Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer
US20220073554A1 (en) Lincosamide antibiotics and uses thereof
AU2019383674A1 (en) Novel imidazole derivative
CA2963815A1 (en) 14-membered ketolides and methods of their preparation and use
RU2532441C2 (ru) Способ получения производных пирипиропена
CA2980315A1 (en) Macrolides with modified desosamine sugars and uses thereof
AU2019385333B2 (en) C10-alkylene substituted 13-membered macrolides and uses thereof
Cowled et al. The chemical gymnastics of enterocin: evidence for stereodivergence in Nature
JP5759983B2 (ja) 抗癌活性を有するシクロアルタノン誘導体
Singh et al. Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues
ITMI960236A1 (it) Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
Masood-ur-Rahman et al. Synthesis and antimicrobial activity of triazolyl analogs of diosgenin
Mugunthan et al. Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents
Lee et al. Atomistic analysis of radiation-induced segregation in ion-irradiated stainless steel 316
IT201900012888A1 (it) Inibitori della antibiotico-resistenza mediata da ArnT
Pillai BRIDGING COMPLEXITY AND THERAPEUTICS: TOTAL SYNTHESIS OF LIMONOID NATURAL PRODUCTS AND DEVELOPMENT OF NOVEL ANTIBACTERIAL SULFA-DRUGS
Lazarevski et al. New oleandomycin 9-oximes synthesis, characterization and biological activity
Lee The Discovery of Novel Macrolide Antibiotics that Address Bacterial Resistance
Davis Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
Follows Studies directed toward the synthesis of the calicheamicin ABE core trisaccharide
Budnikova et al. Ionic Hydrogenation of 8-Aza-16-thiagona-1, 3, 5 (10), 13-tetraene-12, 17-diones. Synthesis and Properties of 8-Aza-16-thiagona-1, 3, 5 (10), 13-tetraen-17-ones
JP2013509377A (ja) 抗癌剤としてのポリケチド分子

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)