JP6731979B2 - Medical examination cassette and paraffin block making tool - Google Patents

Description

The present invention relates to a cassette for medical examination and a paraffin block making tool used for producing a microscope specimen for medical examination. More specifically, it is possible to prevent burrs from occurring and attach an embedding tray to the bottom of the cassette body. The present invention relates to a medical examination cassette and a paraffin block making tool which are easy to do.

As shown in FIGS. 16 and 17, a conventional medical examination cassette of this type (hereinafter sometimes simply referred to as a cassette) includes a cassette body C1 made of a chemical resistant synthetic resin and a lid C2. It becomes. The cassette body C1 is a rectangular container having an open upper surface, has a large number of through holes C3 in the bottom surface, and is a plate-shaped recording portion that is inclined outwardly toward the bottom surface on the outside of one short side wall. C1a is provided. The lid C2 is a detachable plate-like body, and has a large number of through holes C3 in the plate surface.

To prepare a microscope sample using the cassette C, first, as shown in FIG. 17, the sample S collected is housed in the cassette body C1 and the lid C2 is attached, and the subject C1a is attached to the recording unit C1a. Record the symbol etc. to identify the.

Subsequently, the sample S is washed with water through the through hole C3 of the lid C2, the moisture of the sample S is removed with alcohol, the fat content of the sample S is removed with xylene, and the affinity with liquid paraffin described later is imparted. ..

Next, a liquid paraffin P is put into a stainless steel embedding tray (hereinafter, may be simply referred to as a tray) T as shown in FIG. 18, the sample S is taken out from the cassette body C1, and is placed in the tray T. After transfer, the liquid paraffin is permeated into the sample S in the tray T and the sample S is temporarily fixed. Subsequently, the cassette body C1 is placed on the stepped portion of the tray T, and the liquid paraffin P is further poured onto the sample S until the bottom surface portion of the cassette body C1 is immersed in the liquid paraffin P (see FIG. 19).

After the liquid paraffin P is solidified, the tray T is removed to obtain the paraffin block B in which the paraffin P embedding the sample S is attached to the bottom surface portion of the cassette body C1 (see FIG. 20).

Next, although not shown, the paraffin block B is placed upside down on the microtome, and the paraffin block B is fixed to the microtome by engaging the adapter installed on the microtome with the paraffin block B. Subsequently, a portion of the paraffin P in which the sample S is embedded is sliced, the obtained thin piece is stained, and other predetermined processing is performed to obtain a microscope sample.

However, when the paraffin block B is created by the above method, the paraffin rises up on the horizontal frame portion T1 horizontally provided from the upper end portion of the tray T, and the paraffin is cooled and solidified in this state, so that this portion is The burr b remains on the paraffin block B. Since this burr hinders the adapter from engaging with the paraffin block B when fixing the paraffin block B to the microtome, it is necessary to scrape off the burr with a cutter or the like, but the cooled and solidified paraffin is hard and difficult to scrape. The deburring work is complicated.

To prevent deburring work, there has been proposed a tray (see Patent Document 1) in which a frame portion is not provided and a narrow cassette support portion is formed at the boundary between the side wall portion and the locking wall. Since the tray has a narrow cassette supporting portion, it is not always easy to mount the cassette on the tray. In order to solve this problem, a large cassette support portion is formed at the corner of the tray (see Patent Document 2), the cassette is clamped by a clamp plate that is inclined inward (see Patent Document 3), and a small claw portion is used. Has been proposed to prevent the cassette from sliding (see Patent Document 4). These techniques have an advantage that the cost can be reduced because the conventional cassette can be used as it is.

JP, 2008-145118, A JP, 2008-145218, A JP, 2008-180625, A JP, 2009-042075, A

However, in spite of the above-mentioned improvements, in all of these trays, horizontal cassette bearings are formed and paraffin is retained there, so that it is not possible to sufficiently prevent burr generation. The problem that it is difficult to mount the cassette on the tray has not been solved.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a cassette that prevents burr generation and is easy to mount on a tray, and a paraffin block making tool using this cassette.

A feature of the present invention for achieving the above-mentioned object is a cassette for medical examination in which an embedding tray can be mounted on the back surface of the bottom, and a cassette body having a rectangular container open upward and having a large number of through holes in the bottom. , A lid having a large number of through holes, and a groove-like fitting portion is provided at a position where the upper edge portion of the embedding tray abuts on the bottom rear surface of the cassette body, and the fitting portion has both ends. Is a medical examination cassette which is a linear groove opened to the side of the cassette body .

Yet another feature of the present invention includes the above-mentioned medical examination cassette in which the fitting portion is provided so as to abut the entire upper edge portion of the embedding tray.

Still another feature of the present invention is a paraffin block making tool comprising the above-mentioned medical examination cassette and an embedding tray, wherein the embedding tray has at least a paraffin block adapter for mounting the paraffin block on a microtome. Has a shape in which an upper edge portion is erected on a side contacting with, and the upper edge portion contacts a fitting portion provided on the bottom portion of the medical examination cassette when the upper edge portion is attached to the bottom portion of the medical examination cassette. The contents are the paraffin block making tools that come into contact.

Yet another feature of the present invention includes the paraffin block making tool described above in which the upper edge portion is erected vertically.

Still another feature of the present invention includes the above paraffin block making tool in which the upper edge of the embedding tray is provided upright over the entire circumference.

Still another feature of the present invention is that, in the edge portion of the embedding tray, a grip portion that extends horizontally in the upper edge portion on the side where the adapter for mounting the paraffin block on the microtome does not contact the paraffin block. The above-mentioned paraffin block making tool in which is formed is the content.

In the medical examination cassette of the present invention, the upper edge portion of the tray is fitted into the fitting portion of the cassette to prevent the paraffin from flowing out, so that the occurrence of burrs is prevented. In addition, since the fitting portion is provided on the back surface of the bottom of the cassette body along the position where the edge of the embedding tray abuts, it is possible to fit the fitting portion with the upper edge of the embedding tray. , The embedding tray can be easily attached to the bottom of the cassette.

Further, if the shape of the fitting portion is a groove shape, the groove-shaped fitting portion of the cassette and the upper edge portion of the tray are fitted, so that the outflow of paraffin can be prevented more reliably.

If the mating part is a straight groove with both ends open to the side of the cassette body, even if paraffin is clogged in the mating part, it can be clogged by tracing the inside of the mating part with a pin or knife. Paraffin can be easily extruded and removed.

If the fitting portion is provided so as to contact the entire upper edge of the tray, the gap for paraffin leakage between the cassette and the tray is eliminated over the entire circumference, so that the occurrence of burrs can be prevented more effectively. It

By forming an extrusion hole that penetrates from the top or side surface of the cassette body to the fitting portion on the bottom surface, when removing the tray from the paraffin block, you can insert an elongated rod-shaped member into the extrusion hole and push the upper edge of the tray. , The tray can be easily removed from the paraffin block.

If the upper edge of the tray is erected in the vertical direction, it is easy to fit the upper edge and the fitting portion of the cassette, and the workability is improved. In particular, when the shape of the fitting part is groove-shaped, the upper edge of the tray fits into this groove-shaped fitting part, so that the outflow of paraffin can be more reliably stopped and the occurrence of burrs is more effective. Be prevented.

If the embedding tray is provided with the grip portion, the tray can be easily handled, and thus workability is increased.

FIG. 1A is a side view showing an example of the medical examination cassette of the present invention, and FIGS. 1B and 1C are bottom views thereof. FIG. 2 is a sectional view of the cassette of FIG. FIG. 3 is a cross-sectional view showing another example of the medical examination cassette and an enlarged view of a main part. FIG. 4 is a cross-sectional view showing another example of the medical examination cassette and an enlarged view of a main part. FIG. 5A is a side view showing another example of the medical examination cassette, and FIG. 5B is a bottom view thereof. FIG. 6A is a side view showing still another example of the medical examination cassette, and FIG. 6B is a bottom view thereof. FIG. 7(a) is a front view showing an example of an embedding tray used with the medical examination cassette of the present invention, and FIG. 7(b) is a plan view thereof. FIG. 8 is a plan view showing another example of the embedding tray. FIG. 9 shows a paraffin block forming tool including the medical examination cassette of FIGS. 1 and 2 and the embedding tray of FIG. 7. FIG. 10 shows a paraffin block making tool comprising the medical examination cassette of FIG. 3 and the embedding tray of FIG. FIG. 11 shows a paraffin block making tool including the medical examination cassette of FIG. 4 and the embedding tray of FIG. FIG. 12(a) is a bottom view showing the cassette body in which the extrusion holes are formed, and FIG. 12(b) is a sectional view taken along line BB thereof. FIG. 13 is a schematic explanatory diagram illustrating a state in which a push-out rod is inserted into the push-out hole and the embedding tray is peeled off from the paraffin block. FIG. 14 is a schematic cross-sectional view showing another example of the cassette body having the extrusion holes. FIG. 15 shows a paraffin block making tool including the medical examination cassette of FIG. 5 and the embedding tray of FIG. FIG. 16 is a perspective view showing a conventional medical examination cassette. FIG. 17 is a sectional view showing a state in which a sample is put in a conventional medical examination cassette. FIG. 18 is a perspective view of an embedding tray used with a conventional medical examination cassette. FIG. 19 is a cross-sectional view showing a method for producing a paraffin block. FIG. 20 is a sectional view showing the obtained paraffin block.

The present invention is a medical examination cassette 1 in which an embedding tray 4 can be attached to the back surface of a bottom portion 2b of a cassette body 2, and as shown in FIGS. Including a cassette body 2 having a through hole 2a and a lid 3 having a large number of through holes 3a, and a groove at a position where the upper edge portion 4a of the embedding tray 4 abuts on the back surface of the bottom portion 2b of the cassette body 2. It is characterized in that a fitting portion 2c having a shape of a circle is provided. FIG. 1B shows an example in which the groove-shaped fitting portion 2c is provided around the portion of the bottom surface 2b of the cassette body 2 where the through hole 2a is provided, and in FIG. In this example, the recording portion 2d is extended to the bottom surface.

In the present invention, the cassette body 2 is a rectangular container that opens upward, and has a large number of through holes 2a at the bottom as shown in FIG. 1(b). In this example, the shape of the through hole 2a is a square, but the shape is not particularly limited, and may be, for example, a circle, an ellipse, a polygon, or the like.

The lid 3 according to the present invention is attached to the opening of the cassette body 2 and has a large number of through holes 3a like the bottom 2b of the cassette body 2.

In this example, the lid body 3 has a rectangular shape and a structure in which a rib is provided on the lower side is adopted, but the shape of the lid body 3 and the attachment structure to the cassette body 2 are not particularly limited, and this kind of All shapes and structures that can be used in the medical examination cassette 1 can be applied to the present invention.

3 and 4 show other examples of the cassette of the present invention. In the cassette of FIG. 3, a stepped fitting portion 2c is formed by cutting out the outer edge portion of the bottom portion 2b of the cassette body 2. Also, in the cassette of FIG. 4, a step-like fitting portion 2c is formed by cutting out the inner portion while leaving the outer edge portion.

FIG. 5 shows another example of the cassette of the present invention, in which a fitting portion 2c is formed on two opposing sides (short sides in the figure) of the bottom portion 2b of the cassette body 2. When the paraffin block is attached to the microtome, the sides where the adapter contacts the microtome are the two opposite sides (short sides in the figure), so it is sufficient to prevent burrs from occurring on these two sides. This is an example in which the fitting portion 2c is provided in the.

Note that, in the example shown in FIG. 5, the fitting portion 2c is a linear groove whose both ends are open to the side of the cassette body 2. Therefore, even if the fitting portion 2c is clogged with paraffin or dust, it is possible to easily scrape off and remove the paraffin or dust in the fitting portion 2c by tracing the inside of the fitting portion 2c with a knife or a thin plate. it can.

Further, in the example shown in FIG. 6, the fitting portion 2c is formed by combining four linear grooves whose both ends are open to the side of the cassette body 2. By using the medical cassette provided with such a fitting portion 2c, it is possible to achieve both the effect of preventing the occurrence of burrs on all sides and the effect of facilitating the cleaning of the inside of the fitting portion.

The paraffin block making tool of the present invention comprises the cassette 1 and the embedding tray 4.

FIG. 7 shows an example of the embedding tray 4 used with the cassette of the present invention. In this example, the vicinity of the upper edge portion 4a of the embedding tray 4 is vertically provided so as to be easily fitted to the fitting portion 2c formed on the bottom portion 2b of the cassette body 2.

FIG. 8 shows another example of the embedding tray 4, in which a gripping portion 4b is formed in the horizontal direction at the center of the upper edge of two opposite sides (long sides in the figure) of the embedding tray 4. In this case, the two opposing sides are the sides where the adapter does not come into contact with the microtome, that is, the two sides which do not cause any trouble even if burrs are generated.

FIG. 9 shows a paraffin block making tool including the cassette 1 shown in FIGS. 1A and 1B and the embedding tray 4 shown in FIG. In the preparation tool of this example, the groove-shaped fitting portion 2c provided on the bottom portion 2b of the cassette body 2 and the upper edge portion 4a of the embedding tray 4 are fitted and fitted to each other, and paraffin is prevented from flowing out and burrs are removed. Is prevented from occurring. Further, since the recess 2c and the upper edge 4a may be fitted and fitted, the cassette 1 and the embedding tray 4 can be easily mounted. In this case, it is preferable that the groove-shaped fitting portion 2c has a taper shape that widens toward the entrance in order to facilitate fitting and fitting of the upper edge portion 4a of the embedding tray 4. Further, it is preferable that the upper edge portion 4a of the embedding tray 4 also has a taper shape that shrinks toward the tip end portion and is designed to be in close contact with the tapered groove-shaped fitting portion 2c. When the groove-shaped fitting portion 2c is fitted/fitted with the upper edge portion 4a of the embedding tray 4, the groove-shaped fitting portion 2c is in contact with the three surfaces to prevent outflow of paraffin.

FIG. 10 shows a paraffin block making tool comprising the cassette 1 of FIG. 3 and the embedding tray 4 of FIG. In the preparation tool of this example, the stepped fitting portion 2c provided on the bottom portion 2b of the cassette body 2 and the upper edge portion 4a of the embedding tray 4 are fitted to each other to prevent the outflow of paraffin and generate burrs. Is prevented. Further, since it is only necessary to fit the stepped fitting portion 2c and the upper edge portion 4a, the cassette 1 and the embedding tray 4 can be easily mounted. In the case of the step-shaped fitting portion 2c, when fitted with the upper edge portion 4a of the embedding tray 4, the two surfaces are in contact with each other to prevent the outflow of paraffin.

FIG. 11 shows a paraffin block making tool comprising the cassette 1 of FIG. 4 and the embedding tray 4 of FIG. In the creation tool of this example, as in the paraffin block creation tool of FIG. 10, the stepped fitting portion 2c provided on the bottom portion 2b of the cassette body 2 and the upper edge portion 4a of the embedding tray 4 are fitted together. By contacting the two surfaces, the outflow of paraffin is stopped, and the occurrence of burrs is prevented. Further, since it is only necessary to fit the stepped fitting portion 2c and the upper edge portion 4a, the cassette 1 and the embedding tray 4 can be easily mounted.

By the way, when the embedding tray 4 in which the entire upper edge portion 4a is erected vertically as shown in FIG. 7 is used, it is excellent in that the outflow of paraffin is stopped and burr is prevented. It may be difficult to remove the tray 4 from the paraffin block B.

In such a case, as shown in FIG. 12, a medical treatment in which a push-out hole 2e penetrating from the upper surface or the side surface (the upper surface in the example shown in FIG. 12) of the cassette body 2 to the fitting portion 2c on the bottom surface is formed. The inspection cassette 1 may be used. For example, as shown in FIG. 13, by inserting the pushing rod 2f into the pushing hole 2e and pushing the upper edge portion 4a of the embedding tray 4 with this pushing rod 2f, the embedding tray 4 can be easily removed from the paraffin block B. Can be removed.

The number of the extrusion holes 2e is not particularly limited, and may be provided not only on one side but also on two sides, three sides, or on all four sides. Further, a horizontal pressing head can be provided at the tip of the push rod 2f so that it can be easily pressed. In this case, after inserting the extruding rod 2f into the extruding hole 2e, the top and bottom are turned upside down to push the tip of the extruding rod 2f or the pressing head against the surface of a desk, a work table, or the like to cover the paraffin block B from the paraffin block B. The burying tray 4 can be removed with one touch, and workability can be improved. Further, a female screw is engraved inside the extrusion hole 2e, a male screw is engraved on the outer periphery of the extrusion rod 2f, and the extrusion rod 2f is screwed into the extrusion hole 2e to enter the extrusion rod 2f. It is also possible to remove the filling tray 4.

In the examples shown in FIGS. 12 and 13, the extrusion hole 2e is formed perpendicularly to the cassette body, but as shown in FIG. 14, it may be formed obliquely. In the case of piercing in an oblique direction, it is preferable that the side wall of the embedding tray 4 has an angle closer to vertical than the angle of inclination. In this case, as shown in FIG. 14, the push-out hole 2e may be a hole penetrating from the side surface to the bottom surface of the cassette body 2.

FIG. 15 shows a paraffin block making tool comprising the cassette 1 of FIG. 5 and the embedding tray 4 of FIG. In the preparation tool of this example, the groove-shaped fitting portion 2c provided on the bottom portion 2b of the cassette body 2 and the upper edge portion 4a of the embedding tray 4 are fitted and fitted to each other, and paraffin is prevented from flowing out and burrs are removed. Is prevented from occurring. Further, since the groove-shaped fitting portion 2c and the upper edge portion 4a may be fitted and fitted, the cassette 1 and the embedding tray 4 can be easily mounted.

In this example, as described above, the side where the adapter is in contact with the microtome is the opposite short side (Fig. 15(a)). Therefore, even if burrs occur on the long side where the adapter does not contact the microtome, it does not matter. Therefore, the gripping portion 4b is provided in the horizontal direction from the upper edge portion of the embedding tray 4.

In the present invention, the material of the cassette body 2 and the lid 3 is not particularly limited as long as it is a hard member having chemical resistance, but it is preferably made of resin from the viewpoint of moldability and light weight. Examples of synthetic resins that can be used in the present invention include POM resins (polyacetal resins), ABS resins (acrylonitrile-butadiene-styrene copolymer resins), AAS resins (acrylonitrile/acrylic rubber/styrene resins), AES resins (acrylonitrile/ethylene). Propylene rubber/styrene resin), AS resin (acrylonitrile/styrene resin), PS resin (polystyrene resin), PMMA resin (polymethylmethacrylate resin), PVC resin (polyvinylidene chloride resin), MS resin (methylmethacrylate/styrene resin) , PP resin (polypropylene resin), PE resin (polyethylene resin), PBT resin (polybutylene terephthalate resin), PC resin (polycarbonate resin), and the like, polylactic acid resin, polybutylene succinate, polyamide 11, polyhydroxybutyric acid. Biodegradable plastics such as, and biomass plastics can also be used.

In the present invention, the material of the embedding tray 4 is not particularly limited, and any material that can be used for this type of embedding tray can be used. Specifically, metal is preferable in terms of excellent heat dissipation, and among these, stainless steel, iron, copper, aluminum and the like are more preferable in terms of a good balance between cost and strength, and stainless steel is particularly preferable in terms of excellent durability. ..

As described above, according to the medical examination cassette and paraffin block making tool of the present invention, it is possible to prevent the occurrence of burrs, and it is easy to attach the embedding tray to the bottom of the cassette body. It is highly efficient and extremely useful as a medical examination cassette and paraffin block making tool.

1 Cassette for Medical Examination 2 Cassette Body 2a Through Hole 2b Bottom 2c Fitting 2d Recording Section 2e Extrusion Hole 2f Extrusion Rod 3 Lid 3a Through Hole 4 Embedding Tray 4a Upper Edge 4b Grip S S Specimen C Conventional Medical Examination Cassette C1 cassette body C1a recording part C2 lid C3 through hole T conventional embedding tray T1 frame part P paraffin B paraffin block b burr

Claims (6)

A cassette for medical examination in which an embedding tray can be attached to the back surface of the bottom,
Including a cassette body having a large number of through holes in the bottom of a rectangular container that opens upward, and a lid body having a large number of through holes,
The bottom surface of the bottom of the cassette body is provided with a groove-shaped fitting portion at a position where the upper edge of the embedding tray abuts,
The medical fitting cassette according to claim 1, wherein both ends of the fitting portion are linear grooves that are open to the sides of the cassette body. The cassette for medical examination according to claim 1, wherein the fitting portion is provided so as to come into contact with the entire upper edge portion of the embedding tray. A paraffin block making tool comprising the cassette for medical examination according to claim 1 or 2 and an embedding tray,
The embedding tray has a shape in which an adapter for mounting the paraffin block on the microtome is in contact with the paraffin block, and an upper edge portion is erected.
A paraffin block making tool, wherein the upper edge portion abuts on a fitting portion provided on the bottom portion of the medical examination cassette when the paraffin block is attached to the bottom portion of the medical examination cassette. The paraffin block making tool according to claim 3 , wherein an upper edge portion is provided upright in a vertical direction. The paraffin block making tool according to claim 3 or 4 , wherein an upper edge portion of the embedding tray is provided upright over the entire circumference. Of the edges of the embedding tray, a gripping part extending horizontally is formed at the upper edge on the side where the adapter for mounting the paraffin block on the microtome does not contact the paraffin block. The paraffin block making tool according to any one of claims 3 to 5 .

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