JP6721644B2 - 蛍光ベースのレーザーアブレーションのためのシステム及び方法 - Google Patents
蛍光ベースのレーザーアブレーションのためのシステム及び方法 Download PDFInfo
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Description
[0001] 本願は、2014年10月1日に出願された米国特許出願第14/503,706号の優先権を主張するものであり、その出願のすべての内容が参照により本明細書に組み込まれる。
[0026] 図1Aは、一実施形態による装置100を示す。装置100は、励起光源102を含み得る。励起光源102は、励起光104を生成するように構成され得る。励起光源102は、ヘリウムネオン(HeNe)レーザーなどのレーザーを含み得る。代替的に、励起光源102は、キセノンランプ若しくは水銀ランプ、発光ダイオード、又は蛍光体の蛍光特性を励起するように構成される別の光源であり得る。換言すれば、励起光源102は、励起光104を生成してよく、励起光104は、蛍光体の励起波長に対応する波長を有する光を含み得る。励起光104は、380ナノメートル〜1.4ミクロンの間の波長範囲の光を含み得るが、これに限定されない。
[0044] 図3は、一実施形態による方法300を示す。方法300は、任意の順序で実行され得るブロックを含む。さらに、この開示の意図される範囲内で方法300に種々のブロックが追加されてよいし、方法300から種々のブロックが取り去られてもよい。方法300は、図1A〜図1C及び図2に関連して例示及び説明されている装置100又は装置200を使用して実行され得るステップに対応し得る。
[0059] 図5は、一実施形態によるトポグラフィマッピングシナリオ500を示す。トポグラフィマッピングシナリオ500は、本明細書の他の場所で説明されているのと同様又は同一の要素を含み得る。例えば、トポグラフィマッピングシナリオ500は、図1A〜図1C及び図2に関連して例示及び説明されている装置100及び装置200からの要素を含み得る。さらに、トポグラフィマッピングシナリオ500は、本明細書で説明されている方法からの種々のブロック、例えば、方法400のブロック402、404、及び414に関連し得る。
Claims (11)
- 装置であって、
蛍光体の励起波長に対応する波長を有する光を含む励起光を生成するように構成される励起光源であって、前記蛍光体は、前記励起波長の光を受光すると、これに応答して、放出波長の放出光を放出するように構成される、励起光源と、
組織を切除するように構成されるアブレーション光を生成するように構成されるアブレーション光源と、
前記励起光源及び前記アブレーション光源に光学的に結合されるビームコンバイナと、
出射開口であって、前記装置は前記励起光源によって生成された励起光及び前記アブレーション光源によって生成されたアブレーション光が前記出射開口を通って前記装置を出るように構成された、出射開口と、
カメラと、
命令を実行するようにプログラムされたコンピュータを含むコントローラと、
を含み、
前記命令は、
前記励起光源に前記出射開口を通って励起光を出射させることと、
前記カメラに少なくとも特定の組織位置の画像を取り込ませることと、
前記カメラの位置と、前記出射開口の位置と、前記特定の組織位置への前記励起光の角度に基づいて、三角測量法を使用して、(i)前記アブレーション光の焦点距離又は(ii)前記出射開口から前記特定の組織位置までの距離のうちの少なくとも1つを決定することと、
を含む、装置。 - 前記カメラに少なくとも前記特定の組織位置の画像を取り込ませることは、前記励起光による照明に応答して前記蛍光体によって放出された放出光を検出することを含み、
前記装置は、
前記ビームコンバイナに光学的に結合され、前記特定の組織位置を含む複数の組織位置のいずれかへ前記励起光及び前記アブレーション光を向けるように動作可能なビームスキャナをさらに含み、
前記命令は、
前記ビームスキャナに、前記特定の組織位置へ前記励起光を向けさせることと、
前記特定の組織位置における前記放出波長の放出光を示す前記画像に基づいて蛍光状態を決定することと、
前記蛍光状態に応じて、前記アブレーション光源にアブレーション光を生成させ、前記ビームスキャナに前記アブレーション光を前記特定の組織位置へ向けさせることと、
をさらに含む、請求項1の装置。 - 前記ビームスキャナに光学的に結合される光学システムをさらに含み、前記光学システムは出射開口及びレンズを含む、請求項2の装置。
- 前記ビームスキャナは、前記複数の組織位置を包含する偏向範囲内で前記励起光及び前記アブレーション光を偏向するように動作可能な二重検流計スキャニングミラーを含む、請求項2の装置。
- 前記コントローラは、前記アブレーション光源がアブレーション光を生成している間に、前記カメラに、少なくとも前記特定の組織位置の第2の画像を取り込ませ、前記第2の画像に基づいて前記アブレーション光源を制御するようにさらに構成される、請求項2の装置。
- 前記ビームコンバイナ及び前記ビームスキャナに光学的に結合されるビーム送出システムをさらに含み、前記ビーム送出システムは光ファイバを含む、請求項2の装置。
- 前記ビームコンバイナは、光ファイバY型カプラを含む、請求項1の装置。
- 前記コントローラは、決定された(i)前記アブレーション光の焦点距離又は(ii)前記出射開口から前記特定の組織位置までの距離のうちの少なくとも1つに基づいて、少なくとも前記特定の組織位置のトポグラフィカルマップを決定するようにさらに構成される、請求項1の装置。
- 前記励起光源はレーザーを含み、前記励起波長は、380nm〜1.4ミクロンの間である、請求項1の装置。
- 前記アブレーション光源は、1.4ミクロン〜12ミクロンの間のアブレーション波長の前記アブレーション光を生成するように構成される炭酸ガス(CO2)レーザーを含む、請求項1の装置。
- 前記ビームコンバイナは二色性物質を含む、請求項1の装置。
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Application Number | Priority Date | Filing Date | Title |
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US14/503,706 | 2014-10-01 | ||
US14/503,706 US10052154B2 (en) | 2014-10-01 | 2014-10-01 | System and method for fluorescence-based laser ablation |
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JP2018163180A Active JP6721644B2 (ja) | 2014-10-01 | 2018-08-31 | 蛍光ベースのレーザーアブレーションのためのシステム及び方法 |
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US (2) | US10052154B2 (ja) |
EP (2) | EP3185805B1 (ja) |
JP (2) | JP6397570B2 (ja) |
CN (1) | CN106999244B (ja) |
AU (1) | AU2015325101B2 (ja) |
CA (2) | CA3106226A1 (ja) |
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EP3558150A1 (en) * | 2016-12-22 | 2019-10-30 | Advanced Osteotomy Tools - AOT AG | Laser ablating device and methods for operating and manufacturing such a device |
JP6841669B2 (ja) * | 2017-01-19 | 2021-03-10 | 浜松ホトニクス株式会社 | 観察装置及び観察方法 |
US11394296B2 (en) * | 2017-10-11 | 2022-07-19 | Verily Life Sciences Llc | Voltage driver for electrowetting lens |
CN108245126A (zh) * | 2018-03-26 | 2018-07-06 | 精微视达医疗科技(武汉)有限公司 | 一种可以激光消融的探头式共聚焦显微内窥镜 |
CN109581651B (zh) * | 2018-12-10 | 2020-10-20 | 北京航空航天大学 | 一种用于医疗机器人的激光扫描装置 |
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