JP6718376B2 - 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 - Google Patents

抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 Download PDF

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JP6718376B2
JP6718376B2 JP2016549493A JP2016549493A JP6718376B2 JP 6718376 B2 JP6718376 B2 JP 6718376B2 JP 2016549493 A JP2016549493 A JP 2016549493A JP 2016549493 A JP2016549493 A JP 2016549493A JP 6718376 B2 JP6718376 B2 JP 6718376B2
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antipsychotic drug
vmat2 inhibitor
disorder
antipsychotic
administered
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JP2017505316A (ja
JP2017505316A5 (enExample
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サミュエル ロジャー ジェシー ホーア，
サミュエル ロジャー ジェシー ホーア，
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ニューロクライン バイオサイエンシーズ，インコーポレイテッド
ニューロクライン バイオサイエンシーズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016549493A 2014-02-07 2015-02-06 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 Expired - Fee Related JP6718376B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461937223P 2014-02-07 2014-02-07
US61/937,223 2014-02-07
PCT/US2015/014893 WO2015120317A1 (en) 2014-02-07 2015-02-06 Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof

Related Child Applications (1)

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JP2019087459A Division JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

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JP2017505316A JP2017505316A (ja) 2017-02-16
JP2017505316A5 JP2017505316A5 (enExample) 2018-03-22
JP6718376B2 true JP6718376B2 (ja) 2020-07-08

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JP2016549493A Expired - Fee Related JP6718376B2 (ja) 2014-02-07 2015-02-06 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2019087459A Withdrawn JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2021032320A Pending JP2021080294A (ja) 2014-02-07 2021-03-02 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2023195803A Pending JP2024003253A (ja) 2014-02-07 2023-11-17 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

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JP2019087459A Withdrawn JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2021032320A Pending JP2021080294A (ja) 2014-02-07 2021-03-02 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2023195803A Pending JP2024003253A (ja) 2014-02-07 2023-11-17 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

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Country Link
US (4) US9782398B2 (enExample)
EP (2) EP3102239A1 (enExample)
JP (4) JP6718376B2 (enExample)
KR (1) KR102328058B1 (enExample)
CN (3) CN106061506A (enExample)
AU (1) AU2015213778B2 (enExample)
CA (1) CA2938581C (enExample)
ES (1) ES3062021T3 (enExample)
IL (1) IL247127B (enExample)
MX (1) MX378664B (enExample)
NZ (2) NZ760790A (enExample)
RU (2) RU2757221C2 (enExample)
WO (1) WO2015120317A1 (enExample)

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JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ，インコーポレイテッド （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法
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WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
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JP7212958B2 (ja) 2017-12-26 2023-01-26 ▲蘇▼州科睿思制▲葯▼有限公司 バルベナジントシル酸塩の結晶形及びその製造方法並びに用途
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JP2017505316A (ja) 2017-02-16
AU2015213778B2 (en) 2020-04-23
US20160339011A1 (en) 2016-11-24
NZ760790A (en) 2022-11-25
EP4049681B1 (en) 2026-01-07
ES3062021T3 (en) 2026-04-08
IL247127A0 (en) 2016-09-29
RU2016135930A (ru) 2018-03-15
CN106061506A (zh) 2016-10-26
US20200206215A1 (en) 2020-07-02
US20190381029A1 (en) 2019-12-19
AU2015213778A1 (en) 2016-08-18
CN113413385A (zh) 2021-09-21
RU2021128797A (ru) 2021-11-26
RU2016135930A3 (enExample) 2018-10-05
WO2015120317A1 (en) 2015-08-13
EP4049681A1 (en) 2022-08-31
EP3102239A1 (en) 2016-12-14
NZ723107A (en) 2022-11-25
JP2019116515A (ja) 2019-07-18
CN113368110A (zh) 2021-09-10
MX2016010071A (es) 2017-04-27
US20180085364A1 (en) 2018-03-29
US9782398B2 (en) 2017-10-10
JP2024003253A (ja) 2024-01-11
IL247127B (en) 2021-04-29
EP4049681C0 (en) 2026-01-07
CA2938581C (en) 2023-02-28
MX378664B (es) 2025-03-10
KR102328058B1 (ko) 2021-11-17
KR20160132830A (ko) 2016-11-21
RU2757221C2 (ru) 2021-10-12
JP2021080294A (ja) 2021-05-27
CA2938581A1 (en) 2015-08-13

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