JP6709786B2 - Ｅｇｆｒモジュレーターとしての置換２−アミノピリミジン誘導体 - Google Patents

Ｅｇｆｒモジュレーターとしての置換２−アミノピリミジン誘導体 Download PDF

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JP6709786B2
JP6709786B2 JP2017530208A JP2017530208A JP6709786B2 JP 6709786 B2 JP6709786 B2 JP 6709786B2 JP 2017530208 A JP2017530208 A JP 2017530208A JP 2017530208 A JP2017530208 A JP 2017530208A JP 6709786 B2 JP6709786 B2 JP 6709786B2
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cancer
pharmaceutically acceptable
methyl
solvate
indol
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JP2017537114A5 (cg-RX-API-DMAC7.html
JP2017537114A (ja
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ペン，ジュロン
コスタンゾ，マイケル，ジョン
グレコ，マイケル，ニコラス
グリーン，マイケル，アラン
ワイルド，ビクトリア，リン
チャン，ドン
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ベータ ファーマ，インコーポレイテッド
ベータ ファーマ，インコーポレイテッド
ベータ ファーマ（シャンハイ）カンパニー，リミテッド
ベータ ファーマ（シャンハイ）カンパニー，リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017530208A 2014-12-11 2015-12-11 Ｅｇｆｒモジュレーターとしての置換２−アミノピリミジン誘導体 Active JP6709786B2 (ja)

Applications Claiming Priority (5)

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US201462090869P 2014-12-11 2014-12-11
US62/090,869 2014-12-11
US201562166883P 2015-05-27 2015-05-27
US62/166,883 2015-05-27
PCT/US2015/065286 WO2016094821A2 (en) 2014-12-11 2015-12-11 Substituted 2-anilinopyrimidine derivatives as egfr modulators

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JP2017537114A JP2017537114A (ja) 2017-12-14
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JP2020090467A Active JP7181558B2 (ja) 2014-12-11 2020-05-25 Ｅｇｆｒモジュレーターとしての置換２－アミノピリミジン誘導体

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CN (3) CN112375067B (cg-RX-API-DMAC7.html)
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CA (1) CA2970185C (cg-RX-API-DMAC7.html)
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JP2020143131A (ja) * 2014-12-11 2020-09-10 ベータ ファーマ，インコーポレイテッド Ｅｇｆｒモジュレーターとしての置換２−アミノピリミジン誘導体

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JP7030066B2 (ja) 2016-05-26 2022-03-04 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー Ｅｇｆｒ阻害剤化合物
KR20190018494A (ko) * 2016-06-17 2019-02-22 베타 파마, 인크. N-(2-(2-(디메틸아미노)에톡시)-4-메톡시-5-((4-(1-메틸-1h-인돌-3-일)피리미딘-2-일)아미노)페닐)아크릴아미드의 제약 염 및 그의 결정질 형태
CN106243044A (zh) * 2016-06-30 2016-12-21 浙江大学 含卤代丙烯酰胺侧链的嘧啶类衍生物及制备和应用
CN110818690B (zh) * 2016-07-26 2021-08-10 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物
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CN108017633A (zh) * 2018-01-30 2018-05-11 天津大学 N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-2-氟代丙烯酰胺衍生物及应用
KR20210028191A (ko) * 2018-06-18 2021-03-11 유씨비 바이오파마 에스알엘 암을 예방 및 치료하기 위한 gremlin-1 길항제
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CN114430681A (zh) * 2019-09-23 2022-05-03 贝达医药公司 使用egfr和cdk4/6抑制剂的组合治疗egfr突变相关的癌症
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CN114980883A (zh) 2020-01-20 2022-08-30 阿斯利康(瑞典)有限公司 用于治疗癌症的表皮生长因子受体酪氨酸激酶抑制剂
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CA3249080A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab CONDENSED BICYCLIC HETEROAROMATIC COMPOUNDS AND THEIR USE IN CANCER TREATMENT
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JP2020143131A (ja) * 2014-12-11 2020-09-10 ベータ ファーマ，インコーポレイテッド Ｅｇｆｒモジュレーターとしての置換２−アミノピリミジン誘導体
JP7181558B2 (ja) 2014-12-11 2022-12-01 ベータ ファーマ，インコーポレイテッド Ｅｇｆｒモジュレーターとしての置換２－アミノピリミジン誘導体

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PH12017501057A1 (en) 2018-03-05
HK1245634A1 (zh) 2018-08-31
AU2015360360B2 (en) 2020-06-25
JP2020143131A (ja) 2020-09-10
CO2017006962A2 (es) 2017-10-20
CN112457298A (zh) 2021-03-09
CN108024993A (zh) 2018-05-11
US20170362203A1 (en) 2017-12-21
EP3229798A4 (en) 2018-05-30
IL252554A0 (en) 2017-07-31
CN112375067A (zh) 2021-02-19
TW201632512A (zh) 2016-09-16
CN112375067B (zh) 2024-03-15
EA036453B1 (ru) 2020-11-12
CA2970185C (en) 2023-10-17
CA2970185A1 (en) 2016-06-16
WO2016094821A2 (en) 2016-06-16
MX382869B (es) 2025-03-13
AU2015360360A1 (en) 2017-06-08
CN112457298B (zh) 2024-05-07
MX2017007664A (es) 2018-01-23
CN108024993B (zh) 2020-11-06
US10590111B2 (en) 2020-03-17
BR112017012272A2 (pt) 2018-01-30
US11414401B2 (en) 2022-08-16
SG11201704685TA (en) 2017-07-28
WO2016094821A3 (en) 2016-08-25
SG10201909060SA (en) 2019-11-28
US20200216421A1 (en) 2020-07-09
TWI618704B (zh) 2018-03-21
KR20170098865A (ko) 2017-08-30
JP2017537114A (ja) 2017-12-14
EP3229798A2 (en) 2017-10-18
EA201790921A1 (ru) 2017-12-29
JP7181558B2 (ja) 2022-12-01

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