JP6691053B2 - 無線周波数多重化を用いた並行フローサイトメーター - Google Patents

無線周波数多重化を用いた並行フローサイトメーター Download PDF

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JP6691053B2
JP6691053B2 JP2016556971A JP2016556971A JP6691053B2 JP 6691053 B2 JP6691053 B2 JP 6691053B2 JP 2016556971 A JP2016556971 A JP 2016556971A JP 2016556971 A JP2016556971 A JP 2016556971A JP 6691053 B2 JP6691053 B2 JP 6691053B2
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frequency
light
shifted
optical
flow channel
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JP2017516073A (ja
JP2017516073A5 (https=
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ジャラリ，バーラム
ディボールド，エリック
バックリー，ブランドン
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University of California
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/067—Electro-optic, magneto-optic, acousto-optic elements

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
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  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
JP2016556971A 2014-03-18 2015-03-18 無線周波数多重化を用いた並行フローサイトメーター Active JP6691053B2 (ja)

Applications Claiming Priority (3)

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US201461955137P 2014-03-18 2014-03-18
US61/955,137 2014-03-18
PCT/US2015/021264 WO2015143041A1 (en) 2014-03-18 2015-03-18 Parallel flow cytometer using radiofrequency mulitplexing

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JP2017516073A JP2017516073A (ja) 2017-06-15
JP2017516073A5 JP2017516073A5 (https=) 2018-04-26
JP6691053B2 true JP6691053B2 (ja) 2020-04-28

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US (9) US9784661B2 (https=)
EP (2) EP3120130B1 (https=)
JP (1) JP6691053B2 (https=)
ES (1) ES2959506T3 (https=)
WO (1) WO2015143041A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP2943778B1 (en) 2013-01-09 2020-10-28 The Regents of The University of California Apparatus and methods for fluorescence imaging using radiofrequency-multiplexed excitation
JP6691053B2 (ja) 2014-03-18 2020-04-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 無線周波数多重化を用いた並行フローサイトメーター
KR102600559B1 (ko) * 2015-10-13 2023-11-10 벡톤 디킨슨 앤드 컴퍼니 다중모드 형광 이미징 유동 세포 계측 시스템
KR102527830B1 (ko) 2016-03-17 2023-05-02 벡톤 디킨슨 앤드 컴퍼니 고효율 형광 유세포 분석기를 사용하는 세포 선별
CN105717035B (zh) * 2016-04-08 2019-04-23 清华大学 流式细胞术检测装置和方法
KR102381176B1 (ko) 2016-05-12 2022-04-01 비디 바이오사이언시스 개선된 이미지 해상도를 갖는 형광 이미징 유세포 분석법
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FR3077639B1 (fr) * 2018-02-02 2020-02-14 Universite De Rennes 1 Methode de determination d'une vitesse de sedimentation
WO2019199499A1 (en) * 2018-04-13 2019-10-17 University Of Washington Methods and apparatus for single biological nanoparticle analysis
US10733784B2 (en) * 2018-04-27 2020-08-04 Becton, Dickinson And Company Methods and apparatuses for image control and display of particle analyzer images
JP7416729B2 (ja) 2018-06-19 2024-01-17 ベクトン・ディキンソン・アンド・カンパニー 検出器アレイのための可変多重化スイッチ、システム、およびその使用方法
EP3814748B1 (en) 2018-06-28 2026-03-25 Becton, Dickinson and Company Integrated pre-amplification light detection systems and methods of use thereof
EP3837528B1 (en) 2018-08-15 2025-09-17 Becton, Dickinson and Company Flowrate and vacuum controlled fluid management system for a flow type particle analyzer
CN119334855A (zh) 2018-08-30 2025-01-21 贝克顿·迪金森公司 颗粒分析仪的表征和分选
EP3850335B1 (en) * 2018-09-14 2023-08-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Particle analysis method and apparatus for a spectrometry-based particle analysis
JP7489968B2 (ja) 2018-09-14 2024-05-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞選別装置及び方法
WO2020091866A1 (en) 2018-10-30 2020-05-07 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
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WO2020219800A1 (en) 2019-04-24 2020-10-29 Bennubio Inc. Positionally assisted negative particle rejection (panr) to sort and enrich target cells of interest
WO2020231632A1 (en) 2019-05-14 2020-11-19 Becton, Dickinson And Company Phase-calibration for imaging flow cytometry
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JP7561822B2 (ja) 2019-07-10 2024-10-04 ベクトン・ディキンソン・アンド・カンパニー 細胞選別分類を調整するための再構成可能な集積回路
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US20260086018A1 (en) 2024-09-26 2026-03-26 Becton, Dickinson And Company Methods for detector gain modulation and systems for same
EP4726362A1 (en) 2024-10-09 2026-04-15 Becton Dickinson and Company Methods for monitoring flow rate of a flow stream and systems for same
US20260118250A1 (en) 2024-10-25 2026-04-30 Becton, Dickinson And Company Methods for assessing collinearity of multi-autofluorescence spectra of a sample and systems for same

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854050A (en) 1973-09-11 1974-12-10 Department Of Health Education High precision fluorometer for measuring enzymatic substrates in tissue
US4545677A (en) 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
DE3610396A1 (de) 1986-03-27 1987-10-01 Wella Ag Mittel und verfahren zur oxidativen faerbung von haaren
JPH0810306B2 (ja) 1990-01-26 1996-01-31 大日本スクリーン製造株式会社 光ビームの偏向制御方法
US5204884A (en) 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5504337A (en) * 1990-10-10 1996-04-02 Joseph R. Lakowicz Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
WO1992013265A1 (en) * 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US5203339A (en) 1991-06-28 1993-04-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
US5309912A (en) 1991-11-08 1994-05-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multidimensional imaging using a single point detector for a phase encoded modulated optical carrier
US5192870A (en) 1992-01-14 1993-03-09 International Business Machines Corporation Optical submicron aerosol particle detector
US5255257A (en) 1992-03-04 1993-10-19 Lasertape Systems, Inc. Frequency, phase and amplitude control apparatus and method for acousto-optic deflector optimization
US6057814A (en) 1993-05-24 2000-05-02 Display Science, Inc. Electrostatic video display drive circuitry and displays incorporating same
US5296911A (en) 1992-07-16 1994-03-22 Schiapparelli Biosystems, Inc. Optical test system for a chemical analyzer
US5270548A (en) 1992-07-31 1993-12-14 The United States Of America As Represented By The United States Department Of Energy Phase-sensitive flow cytometer
US5293213A (en) 1992-08-12 1994-03-08 Klein Uwe K A Utilization of a modulated laser beam in heterodyne interferometry
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
US5489977A (en) 1993-08-11 1996-02-06 Texaco Inc. Photomeric means for monitoring solids and fluorescent material in waste water using a falling stream water sampler
JPH0961858A (ja) 1995-08-28 1997-03-07 Minolta Co Ltd 音響光学光走査装置
US5968738A (en) 1995-12-06 1999-10-19 The Board Of Trustees Of The Leland Stanford Junior University Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
JPH10148778A (ja) * 1996-11-18 1998-06-02 Minolta Co Ltd マルチビーム発生装置
DE19721881C2 (de) 1997-05-26 1999-05-20 Bosch Gmbh Robert Interferometrische Meßvorrichtung
DE19721882C2 (de) 1997-05-26 1999-04-29 Bosch Gmbh Robert Interferometrische Meßvorrichtung
US6031852A (en) 1997-05-30 2000-02-29 The Regents Of The University Of California Rapid acoustooptic tuner and phase-shifter
US6016196A (en) 1997-06-17 2000-01-18 Massachusetts Institute Of Technology Multiple beam pair optical imaging
US6236454B1 (en) 1997-12-15 2001-05-22 Applied Materials, Inc. Multiple beam scanner for an inspection system
US6642018B1 (en) 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
JP4215397B2 (ja) * 1998-05-14 2009-01-28 ルミネックス コーポレイション 多重分析物診断システム
US6271924B1 (en) 1998-12-29 2001-08-07 Bryan Kok Ann Ngoi Noncontact acoustic optic scanning laser vibrometer for determining the difference between an object and a reference surface
CA2375530A1 (en) 1999-06-23 2000-12-28 Patrick Toomey Water detection and source identification methods for structures using electromagnetic radiation spectroscopy
US6396069B1 (en) 1999-06-25 2002-05-28 Macpherson David C. Topographer for real time ablation feedback having synthetic wavelength generators
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US6507391B2 (en) 2000-08-25 2003-01-14 Amnis Corporation Measuring the velocity of small moving objects such as cells
US6778263B2 (en) 2000-08-25 2004-08-17 Amnis Corporation Methods of calibrating an imaging system using calibration beads
JP2002296178A (ja) * 2001-03-30 2002-10-09 Shimadzu Corp フローセル検出器
US6636623B2 (en) 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
FR2830629B1 (fr) 2001-10-04 2004-01-09 Commissariat Energie Atomique Procede et dispositif de prelevement d'une partie d'un faisceau lumineux, notamment pour appareil d'analyse de fluorescence
DE20216583U1 (de) 2001-12-20 2003-01-23 Leica Microsystems Heidelberg Gmbh, 68165 Mannheim Mikroskop und Durchflusszytometer
US6868347B2 (en) 2002-03-19 2005-03-15 The Regents Of The University Of California System for real time, non-invasive metrology of microfluidic chips
WO2003089901A2 (en) 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
US20060014212A1 (en) 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
DE10225838B4 (de) 2002-06-11 2021-10-21 Leica Microsystems Cms Gmbh Verfahren zur Scanmikroskopie, Scanmikroskop und Vorrichtung zum Codieren eines Beleuchtungslichtstrahles
GB2401431B (en) 2003-04-02 2005-04-27 Amersham Biosciences Uk Ltd Method of, and computer software for, classification of cells into subpopulations
EP1668355A4 (en) 2003-08-28 2011-11-09 Celula Inc METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK
US7803624B2 (en) 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
US7103402B2 (en) 2003-10-02 2006-09-05 Ut-Battelle, Llc Advanced synchronous luminescence imaging for chemical and medical diagnostics
US7590991B2 (en) 2003-10-09 2009-09-15 Terayon Communication Systems, Inc. Method and apparatus for determining channel to which a TV or VCR is tuned
EP2278287B1 (en) 2003-10-27 2016-09-07 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
DE10357584B4 (de) 2003-12-08 2006-06-14 Leica Microsystems Cms Gmbh Verfahren zum Trennen unterschiedlicher Emissionswellenlängen in einem Scanmikroskop
US7133186B2 (en) 2004-06-07 2006-11-07 Electro Scientific Industries, Inc. AOM modulation techniques employing transducers to modulate different axes
EP1871200A4 (en) 2005-03-29 2009-12-09 Homedics Group Canada Co INTERSCAPULARPOLSTER
US8060316B2 (en) 2005-08-02 2011-11-15 Luminex Corporation Methods, data structures, and systems for classifying microparticles
EP1940286A1 (en) 2005-09-29 2008-07-09 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
JP5203951B2 (ja) * 2005-10-14 2013-06-05 ザ ジェネラル ホスピタル コーポレイション スペクトル及び周波数符号化蛍光画像形成
GB0525072D0 (en) 2005-12-09 2006-01-18 Enigma Diagnostics Ltd Fluorescence-based detection methods and apparatus
US7800368B2 (en) 2006-02-17 2010-09-21 Regents Of The University Of Minnesota High field magnetic resonance
US20090323061A1 (en) 2006-02-28 2009-12-31 Lukas Novotny Multi-color hetereodyne interferometric apparatus and method for sizing nanoparticles
JP2007285999A (ja) * 2006-04-20 2007-11-01 Furukawa Electric Co Ltd:The 光測定装置
EP2024893B1 (en) 2006-05-12 2015-03-04 Janssen Diagnostics, LLC A laser illumination system in fluorescent microscopy
ATE440301T1 (de) 2006-05-29 2009-09-15 Olympus Corp Laserscan-mikroskop und mikroskopisches überwachungsverfahren
JP5133600B2 (ja) 2006-05-29 2013-01-30 オリンパス株式会社 レーザ走査型顕微鏡および顕微鏡観察方法
JP2008007652A (ja) 2006-06-29 2008-01-17 Fujifilm Corp アゾ色素、感熱転写記録用インクシート、感熱転写記録方法、カラートナー、インクジェット用インクおよびカラーフィルタ
US7542137B2 (en) 2006-07-24 2009-06-02 University Of Ottawa Pathogen detection using coherent anti-stokes Raman scattering microscopy
WO2008019448A1 (en) 2006-08-18 2008-02-21 Macquarie University Time gated fluorescent flow cytometer
US7697885B2 (en) 2006-09-15 2010-04-13 Aeroflex High Speed Test Solutions, Inc. Multi-band jammer
JP2008089395A (ja) 2006-10-02 2008-04-17 Honda Instrument Service Co Ltd 光触媒計及び光能力測定方法並びにそれに用いるセンサヘッド
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US7400457B1 (en) 2007-01-04 2008-07-15 Stockeryale Canada Inc. Rectangular flat-top beam shaper
US8101426B2 (en) 2007-03-02 2012-01-24 Icyt Mission Technology, Inc. System and method for the measurement of multiple fluorescence emissions in a flow cytometry system
US8290625B2 (en) 2007-04-04 2012-10-16 Beckman Coulter, Inc. Flow cytometer sorter
US7982944B2 (en) 2007-05-04 2011-07-19 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method and apparatus for optical frequency comb generation using a monolithic micro-resonator
JP5619344B2 (ja) 2007-05-04 2014-11-05 マツクス−プランク−ゲゼルシャフト ツール フエルデルング デル ヴイツセンシャフテン エー フアウ モノリシックマイクロ共振器を使用した光周波数コム発生のための装置と方法
WO2009005579A1 (en) 2007-06-14 2009-01-08 The General Hospital Corporation High affinity fluorochrome binding peptides
US8848199B2 (en) 2007-07-10 2014-09-30 Massachusetts Institute Of Technology Tomographic phase microscopy
JP4509163B2 (ja) * 2007-10-26 2010-07-21 ソニー株式会社 微小粒子の測定方法
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9451884B2 (en) 2007-12-13 2016-09-27 Board Of Trustees Of The University Of Arkansas Device and method for in vivo detection of clots within circulatory vessels
GB0800333D0 (en) 2008-01-09 2008-02-20 Ucl Business Plc Beam deflection apparatus and methods
US20090174935A1 (en) 2008-01-09 2009-07-09 Szulczewski Michael J Scanning microscope having complementary, serial scanners
US20090219607A1 (en) 2008-01-17 2009-09-03 Baylor College Of Medicine Method and apparatus for enhanced resolution microscopy of living biological nanostructures
US8565861B2 (en) 2008-05-02 2013-10-22 Olympus Corporation Optical inspection device, electromagnetic wave detection method, electromagnetic wave detection device, organism observation method, microscope, endoscope, and optical tomographic image generation device
WO2009149733A1 (en) 2008-06-13 2009-12-17 Embl Heidelberg Next generation flow cytometer sorter
US8184279B2 (en) 2008-06-16 2012-05-22 The Regents Of The University Of Colorado, A Body Corporate Fourier domain sensing
WO2010032452A1 (ja) 2008-09-19 2010-03-25 三井造船株式会社 強度変調したレーザ光による蛍光検出装置および蛍光検出方法
WO2010045400A2 (en) 2008-10-14 2010-04-22 Tissuevision, Inc. Devices and methods for direct sampling analog time-resolved detection
US8440952B2 (en) 2008-11-18 2013-05-14 The Regents Of The University Of California Methods for optical amplified imaging using a two-dimensional spectral brush
TWI594828B (zh) 2009-05-28 2017-08-11 伊雷克托科學工業股份有限公司 應用於雷射處理工件中的特徵的聲光偏轉器及相關雷射處理方法
EP2267430A1 (de) 2009-06-24 2010-12-29 Masterrind GmbH Vorrichtung und Verfahren zur Selektion von Partikeln
WO2011023593A1 (en) 2009-08-24 2011-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of and apparatus for imaging a cellular sample
GB0919854D0 (en) 2009-11-12 2009-12-30 Stfc Science & Technology Detecting species in a dilute medium
JP5649828B2 (ja) 2010-02-03 2015-01-07 オリンパス株式会社 レーザ顕微鏡装置
JP2011163787A (ja) * 2010-02-05 2011-08-25 Sony Corp 微小粒子分析装置及び微小粒子分析方法
WO2011097032A1 (en) * 2010-02-05 2011-08-11 Cytonome/St, Llc Multiple flow channel particle analysis system
JP5551477B2 (ja) 2010-03-15 2014-07-16 オリンパス株式会社 光源装置およびレーザ走査型顕微鏡装置
US9101573B2 (en) 2010-05-04 2015-08-11 Virginia Tech Intellectual Properties, Inc. Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders
JP2012008055A (ja) 2010-06-25 2012-01-12 Olympus Corp 画像解析方法および画像解析装置
US8384045B2 (en) 2010-07-01 2013-02-26 Sony Corporation Minute particle analyzing device and method
US8941062B2 (en) 2010-11-16 2015-01-27 1087 Systems, Inc. System for identifying and sorting living cells
EP4227666A1 (en) 2010-11-16 2023-08-16 1087 Systems, Inc. System for identifying and sorting living cells
DE102010044013A1 (de) 2010-11-16 2012-05-16 Carl Zeiss Microimaging Gmbh Tiefenauflösungsgesteigerte Mikroskopie
US9066657B2 (en) 2010-11-23 2015-06-30 General Electric Company Methods and systems of optical imaging for target detection in a scattering medium
EP2661614B1 (en) 2011-01-03 2025-03-12 Cytonome/ST, LLC Method and apparatus for monitoring and optimizing particle sorting
CA2826544C (en) 2011-02-04 2020-06-30 Cytonome/St, Llc Particle sorting apparatus and method
DE112012001802T5 (de) 2011-03-18 2014-03-13 Riken Nichtlineares optisches Mikroskop und Nichtlineare optische Mikroskopie
JP5620319B2 (ja) 2011-03-23 2014-11-05 オリンパス株式会社 顕微鏡
US8681827B2 (en) 2011-05-16 2014-03-25 Oewaves, Inc. Generation of single optical tone, RF oscillation signal and optical comb in a triple-oscillator device based on nonlinear optical resonator
JP6035329B2 (ja) 2011-05-26 2016-11-30 ザ ジェネラル ホスピタル コーポレイション 光学的トロンボエラストグラフィーシステム及び血液凝固基準の評価方法
CN108107197B (zh) 2011-07-19 2020-05-08 奥维茨奥成像系统公司 用于检测和/或分类细胞样品中的癌细胞的方法和系统
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
JP5870851B2 (ja) 2012-05-29 2016-03-01 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
WO2014031985A1 (en) 2012-08-24 2014-02-27 The Trustees Of Dartmouth College Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection
US8723104B2 (en) 2012-09-13 2014-05-13 City University Of Hong Kong Methods and means for manipulating particles
EP2906985B1 (en) 2012-10-12 2022-03-09 Thorlabs, Inc. Compact, low dispersion, and low aberration adaptive optics scanning system
CN110579435B (zh) 2012-10-15 2023-09-26 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
EP2943778B1 (en) 2013-01-09 2020-10-28 The Regents of The University of California Apparatus and methods for fluorescence imaging using radiofrequency-multiplexed excitation
US10190963B2 (en) 2013-02-01 2019-01-29 Becton, Dickinson And Company Methods and systems for assessing sample behavior in a flow cytometer
US9335247B2 (en) 2013-03-14 2016-05-10 Cytonome/St, Llc Assemblies and methods for reducing optical crosstalk in particle processing systems
GB201305317D0 (en) 2013-03-22 2013-05-08 Iles Raymond K Prenatal screening for fetal abnormalities and disorders of pregnancy
US9372143B2 (en) 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
JP6257312B2 (ja) 2013-12-24 2018-01-10 オリンパス株式会社 顕微鏡システム
US9538926B2 (en) 2013-12-26 2017-01-10 Fundacio Institut De Ciencies Fotoniques Speckle contrast optical tomography
CN103762487B (zh) 2014-01-04 2016-05-25 天津奇谱光电技术有限公司 一种具有双输出光束的可调谐激光器
JP6214402B2 (ja) 2014-01-07 2017-10-18 オリンパス株式会社 光刺激装置および顕微鏡システム
US10451482B2 (en) 2014-02-14 2019-10-22 Palo Alto Research Center Incorporated Determination of color characteristics of objects using spatially modulated light
JP6691053B2 (ja) * 2014-03-18 2020-04-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 無線周波数多重化を用いた並行フローサイトメーター
US20170052106A1 (en) 2014-04-28 2017-02-23 The Broad Institute, Inc. Method for label-free image cytometry
EP3198243B1 (en) 2014-09-30 2020-07-22 The Regents of the University of California Imaging flow cytometer using spatial-temporal transformation
KR102446523B1 (ko) 2014-11-12 2022-09-22 오르보테크 엘티디. 다중 출력 빔을 갖는 음향-광학 편향기
WO2017053592A1 (en) 2015-09-23 2017-03-30 The Regents Of The University Of California Deep learning in label-free cell classification and machine vision extraction of particles
KR102600559B1 (ko) 2015-10-13 2023-11-10 벡톤 디킨슨 앤드 컴퍼니 다중모드 형광 이미징 유동 세포 계측 시스템
US10337997B2 (en) 2015-10-15 2019-07-02 Woods Hole Oceanographic Institution System for rapid assessment of water quality and harmful algal bloom toxins
WO2017136676A1 (en) 2016-02-05 2017-08-10 Nanoview Diagnostics Inc. Detection of exosomes having surface markers
KR102527830B1 (ko) 2016-03-17 2023-05-02 벡톤 디킨슨 앤드 컴퍼니 고효율 형광 유세포 분석기를 사용하는 세포 선별
WO2017201540A1 (en) 2016-05-20 2017-11-23 Techcyte, Inc. Machine learning classification of particles or substances in digital microscopy images
ES3024557T3 (en) 2016-06-10 2025-06-04 Univ California Image-based cell sorting systems and methods
CN109477785B (zh) 2016-09-13 2022-09-27 贝克顿·迪金森公司 具有光学均衡的流式细胞仪
KR20200055134A (ko) 2017-10-09 2020-05-20 티에스아이 인코포레이티드 입자 계수기 구성요소 교정
WO2019199499A1 (en) 2018-04-13 2019-10-17 University Of Washington Methods and apparatus for single biological nanoparticle analysis
CN119334856A (zh) 2018-04-26 2025-01-21 贝克顿·迪金森公司 颗粒分析仪的表征和分选
WO2020205200A1 (en) 2019-03-29 2020-10-08 Becton, Dickinson And Company Parameters for use in particle discrimination

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