JP6666849B2 - カボザンチニブ製剤の投与 - Google Patents
カボザンチニブ製剤の投与 Download PDFInfo
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- JP6666849B2 JP6666849B2 JP2016558004A JP2016558004A JP6666849B2 JP 6666849 B2 JP6666849 B2 JP 6666849B2 JP 2016558004 A JP2016558004 A JP 2016558004A JP 2016558004 A JP2016558004 A JP 2016558004A JP 6666849 B2 JP6666849 B2 JP 6666849B2
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- cabozantinib
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| EA038195B1 (ru) | 2009-01-16 | 2021-07-22 | Экселиксис, Инк. | Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее применение для лечения рака почек и печени |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| HUE057574T2 (hu) | 2011-02-10 | 2022-05-28 | Exelixis Inc | Eljárás kinolin-származékok és ilyen vegyületeket tartalmazó gyógyászati készítmények elõállítására |
| CN105121412B (zh) * | 2013-03-15 | 2019-07-12 | 埃克塞里艾克西斯公司 | N-(4-{[6，7-双(甲基氧基)喹啉-4-基]氧基}苯基)-n′-(4-氟苯基)环丙烷-1，1-二甲酰胺的代谢物 |
| WO2014165786A1 (en) | 2013-04-04 | 2014-10-09 | Exelixis, Inc. | Cabozantinib dosage form and use in the treatment of cancer |
| US10501418B2 (en) | 2014-02-14 | 2019-12-10 | Exelixis, Inc. | Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use |
| MA39735A (fr) | 2014-03-17 | 2017-01-25 | Exelixis Inc | Dosage de préparations de cabozantinib |
| ES2929888T3 (es) * | 2014-07-31 | 2022-12-02 | Exelixis Inc | Procedimiento para preparar cabozantinib marcado con flúor 18 y sus análogos |
| EP3177311B1 (en) | 2014-08-05 | 2024-10-30 | Exelixis, Inc. | Drug combinations of cabozantinib with proteasome inhibitor to treat multiple myeloma |
| WO2016161952A1 (zh) * | 2015-04-07 | 2016-10-13 | 广东众生药业股份有限公司 | 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物 |
| MA44672A (fr) | 2016-04-15 | 2019-02-20 | Exelixis Inc | Procédé de traitement du cancer à cellules rénales à l'aide de n-(4-(6,7-diméthoxyquinolin-4-yloxy) phényl)-n'-(4-fluorophény)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate |
| CN107951850A (zh) * | 2017-12-20 | 2018-04-24 | 深圳万乐药业有限公司 | 一种苹果酸卡博替尼片的制备方法 |
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| CN113321647B (zh) | 2018-06-15 | 2024-08-27 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
| TW202444365A (zh) | 2023-01-31 | 2024-11-16 | 漢達生技醫藥股份有限公司 | 改良之卡博替尼組合物及其使用方法 |
| WO2025079089A1 (en) * | 2023-10-09 | 2025-04-17 | Msn Laboratories Private Limited, R&D Center | Pharmaceutical composition of cabozantinib |
| WO2025196845A1 (en) * | 2024-03-22 | 2025-09-25 | Meishi Pharma Services Pvt. Ltd. | Improved formulations of cabozantinib |
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| CN105106199A (zh) | 2006-12-14 | 2015-12-02 | 埃克塞利希斯股份有限公司 | 使用mek抑制剂的方法 |
| UY31800A (es) | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| AR075084A1 (es) | 2008-09-26 | 2011-03-09 | Smithkline Beecham Corp | Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes |
| JP5486606B2 (ja) | 2008-11-13 | 2014-05-07 | エクセリクシス， インク． | キノリン誘導体の調製方法 |
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| BR112012001118A2 (pt) | 2009-07-17 | 2016-02-23 | Exelixis Inc | formas cristalinas de n-[3-flúor-4-({6-(metilóxi)-7-[(3-morfolin-4-ilpropil)óxi]-quinolin-4-il}óxi)fenil]-n'-(4-fluorfenil)ciclopropano-1,1-dicarboxamida, composição farmacêutica com as mesmas, métodos de preparação das mesmas e tratamento de câncer |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
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| JP2013540759A (ja) | 2010-09-27 | 2013-11-07 | エクセリクシス， インク． | 去勢抵抗性前立腺癌および造骨性転移の治療のためのｍｅｔおよびｖｅｇｆの二元阻害薬 |
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| EP3177311B1 (en) | 2014-08-05 | 2024-10-30 | Exelixis, Inc. | Drug combinations of cabozantinib with proteasome inhibitor to treat multiple myeloma |
| US20170224670A1 (en) | 2014-10-14 | 2017-08-10 | Exelixis, Inc. | Drug Combination to Treat Melanoma |
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2015
- 2015-03-17 MA MA039735A patent/MA39735A/fr unknown
- 2015-03-17 JP JP2016558004A patent/JP6666849B2/ja active Active
- 2015-03-17 EA EA201691850A patent/EA201691850A1/ru unknown
- 2015-03-17 CN CN201580023083.9A patent/CN106255499A/zh active Pending
- 2015-03-17 US US15/126,767 patent/US10159666B2/en active Active
- 2015-03-17 EP EP15714340.5A patent/EP3119476A1/en not_active Withdrawn
- 2015-03-17 WO PCT/US2015/021072 patent/WO2015142928A1/en not_active Ceased
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2018
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2020
- 2020-01-29 US US16/776,139 patent/US20200163954A1/en not_active Abandoned
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| US20170087143A1 (en) | 2017-03-30 |
| EP3119476A1 (en) | 2017-01-25 |
| US20200163954A1 (en) | 2020-05-28 |
| CN106255499A (zh) | 2016-12-21 |
| MA39735A (fr) | 2017-01-25 |
| JP2017507995A (ja) | 2017-03-23 |
| US10159666B2 (en) | 2018-12-25 |
| US20190076420A1 (en) | 2019-03-14 |
| EA201691850A1 (ru) | 2016-12-30 |
| WO2015142928A1 (en) | 2015-09-24 |
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