JP6659546B2 - 生細胞内への分子の送達のための組成物および方法 - Google Patents
生細胞内への分子の送達のための組成物および方法 Download PDFInfo
- Publication number
- JP6659546B2 JP6659546B2 JP2016540943A JP2016540943A JP6659546B2 JP 6659546 B2 JP6659546 B2 JP 6659546B2 JP 2016540943 A JP2016540943 A JP 2016540943A JP 2016540943 A JP2016540943 A JP 2016540943A JP 6659546 B2 JP6659546 B2 JP 6659546B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- dtat
- compound
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361876006P | 2013-09-10 | 2013-09-10 | |
| US61/876,006 | 2013-09-10 | ||
| PCT/US2014/055021 WO2015038662A1 (en) | 2013-09-10 | 2014-09-10 | Compositions and methods for the delivery of molecules into live cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530303A JP2016530303A (ja) | 2016-09-29 |
| JP2016530303A5 JP2016530303A5 (cg-RX-API-DMAC10.html) | 2017-10-19 |
| JP6659546B2 true JP6659546B2 (ja) | 2020-03-04 |
Family
ID=52666235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540943A Active JP6659546B2 (ja) | 2013-09-10 | 2014-09-10 | 生細胞内への分子の送達のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9662404B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3043811B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6659546B2 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2014318839B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2923664C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2794599T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015038662A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3149413C (en) * | 2015-04-10 | 2025-07-08 | Feldan Bio Inc. | Polypeptide-based carrier agents to improve the transduction efficiency of polypeptide cargo to cytosol in target eukaryotic cells and their uses, methods, and related kits |
| FR3048698B1 (fr) | 2016-03-11 | 2021-03-05 | Univ Claude Bernard Lyon | Inhibiteurs de l'interaction bcl2 l10 / recepteur ip3 |
| US11629170B2 (en) | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| AU2017341736B2 (en) * | 2016-10-12 | 2022-09-08 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| JP7068711B2 (ja) * | 2017-03-22 | 2022-05-17 | 国立大学法人京都大学 | 細胞質送達ペプチド |
| WO2019036375A1 (en) | 2017-08-14 | 2019-02-21 | Sanford Burnham Prebys Medical Discovery Institute | CARDIOGENIC MESODERMA TRAINING REGULATORS |
| US12029804B2 (en) | 2018-11-02 | 2024-07-09 | Soonchunhyang University Industry Academy Cooperation Foundation | Peptide for promoting mucous membrane permeation and composition containing same |
| CN113423834A (zh) | 2018-11-08 | 2021-09-21 | 加总生物公司 | 微核小体核心蛋白及其在核酸递送中的用途 |
| KR102201154B1 (ko) * | 2019-03-26 | 2021-01-12 | 가천대학교 산학협력단 | 폴리글루타메이트-TAT-Cre 융합 단백질의 제조방법 |
| CA3040645A1 (en) | 2019-04-18 | 2020-10-18 | Feldan Bio Inc. | Peptide-based non-proteinaceous cargo delivery |
| EP4136235A4 (en) | 2020-04-13 | 2024-10-16 | Summation Bio, Inc. | MINI-NUCLEOSOME CORE PROETIN AND THEIR USE IN NUCLEIC ACID DELIVERY |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258774B1 (en) * | 1998-03-19 | 2001-07-10 | University Of Medicine And Dentistry Of New Jersey | Carrier for in vivo delivery of a therapeutic agent |
| EP1968643A2 (en) | 2005-12-16 | 2008-09-17 | Diatos | Cell penetrating peptide conjugates for delivering of nucleic acids into a cell |
| AU2008329563A1 (en) * | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving Oct4 protein |
| WO2010059806A2 (en) * | 2008-11-20 | 2010-05-27 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells without the use of viral vectors |
| WO2010072228A1 (en) * | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| US20120128655A1 (en) * | 2009-04-03 | 2012-05-24 | The Mclean Hospital Corporation | Induced pluripotent stem cells |
| CA3032186C (en) | 2010-07-13 | 2022-04-26 | Council on Postsecondary Education, State of Rhode Island and Providence Plantations | Environmentally sensitive composition comprising a ph triggered peptide and uses thereof |
| WO2012090150A2 (en) | 2010-12-27 | 2012-07-05 | Compugen Ltd | New cell-penetrating peptides and uses thereof |
-
2014
- 2014-09-10 EP EP14843936.7A patent/EP3043811B1/en active Active
- 2014-09-10 JP JP2016540943A patent/JP6659546B2/ja active Active
- 2014-09-10 AU AU2014318839A patent/AU2014318839B2/en active Active
- 2014-09-10 US US14/482,946 patent/US9662404B2/en active Active
- 2014-09-10 CA CA2923664A patent/CA2923664C/en active Active
- 2014-09-10 WO PCT/US2014/055021 patent/WO2015038662A1/en not_active Ceased
- 2014-09-10 ES ES14843936T patent/ES2794599T3/es active Active
-
2017
- 2017-05-23 US US15/602,967 patent/US20170258933A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016530303A (ja) | 2016-09-29 |
| CA2923664A1 (en) | 2015-03-19 |
| US9662404B2 (en) | 2017-05-30 |
| EP3043811A4 (en) | 2017-09-20 |
| WO2015038662A1 (en) | 2015-03-19 |
| EP3043811A1 (en) | 2016-07-20 |
| EP3043811B1 (en) | 2020-03-25 |
| US20170258933A1 (en) | 2017-09-14 |
| US20150099690A1 (en) | 2015-04-09 |
| ES2794599T3 (es) | 2020-11-18 |
| AU2014318839B2 (en) | 2019-12-05 |
| CA2923664C (en) | 2023-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9662404B2 (en) | Compositions and methods for the delivery of molecules into live cells | |
| AU2014318839A1 (en) | Compositions and methods for the delivery of molecules into live cells | |
| Lundin et al. | Distinct uptake routes of cell-penetrating peptide conjugates | |
| Fischer et al. | A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides | |
| EP1991560B1 (en) | Peptide having cell membrane penetrating activity | |
| Takayama et al. | Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas) | |
| JP6517692B2 (ja) | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 | |
| Mäger et al. | Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay | |
| AU2017201163A1 (en) | Method of determining, identifying or isolating cell-penetrating peptides | |
| CN102811744A (zh) | 用于改善基因调节化合物的递送的化学修饰的细胞渗透性肽 | |
| Buyanova et al. | Discovery of a cyclic cell-penetrating peptide with improved endosomal escape and cytosolic delivery efficiency | |
| KR101695792B1 (ko) | 신규 세포막 투과 펩티드 및 생리활성 물질 전달체로서의 그의 용도 | |
| JP6617930B2 (ja) | 細胞質送達ペプチド | |
| JPWO2007132555A1 (ja) | 細胞膜透過性ペプチドと細胞内におけるその使用 | |
| US20030113819A1 (en) | Carrier peptide and method for delivery of molecules into cells | |
| EP4297794A2 (en) | Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives | |
| KR20090122769A (ko) | 세포내로 단백질을 전달하는 방법 및 이를 위한 펩타이드 | |
| Najjar et al. | An L-to D-amino acid conversion in the cell penetrating peptide dfTAT influences proteolytic stability, endocytic uptake, and endosomal escape | |
| Yokoo | Peptide and Protein Delivery | |
| US20240400622A1 (en) | Genetically encoded voltage indicators and uses thereof | |
| US20040132970A1 (en) | Dermaseptin-derived peptides and their use in delivery systems | |
| Najjar | Identifying and Characterizing Molecular Parameters that Modulate the Endosomal Escape of Cationic Cell-Penetrating Peptides: A Structure Activity Approach | |
| Howard II | Altering Histone Dynamics in vitro and in vivo | |
| Erazo | Cytosolic Delivery of Proteins, Peptides and Cell-Impermeable Small Molecules Into Live Cells Utilizing Virus-Inspired Multivalent Cell-Penetrating Peptides: Principles and Mechanisms | |
| WO2005087795A1 (es) | Péptidos como portadores penetrantes de células |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170906 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170906 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180822 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20181113 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190221 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190619 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190910 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191219 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200107 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200206 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6659546 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |